Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells - Effects of receptor activity-modifying protein

Acta Physiologica Sinica

Volumn 53, Issue 5, 2001, Pages 396-400

  Qi, Yong Fen ^a   Xue, Lin ^a   Chai, San Bao ^a   Shi, Yan Rong ^a   Pang, Yong Zheng ^a   Tang, Chao Shu ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Adrenomedullin; Calcitonin gene related peptide; Densensitization; Receptor activity modifying protein; Vascular smooth muscle cells

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC AMP; MEMBRANE PROTEIN; PEPTIDE; RECEPTOR;

ANIMAL; ARTICLE; IN VITRO STUDY; MALE; METABOLISM; RAT; VASCULAR SMOOTH MUSCLE; WISTAR RAT;

ADRENOMEDULLIN; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CYCLIC AMP; MALE; MEMBRANE PROTEINS; MUSCLE, SMOOTH, VASCULAR; PEPTIDES; RATS; RATS, WISTAR; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, PEPTIDE;

EID: 1542441025     PISSN: 03710874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Kitamura K, Kangawa K, Kawanoto et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun, 1993, 192:553 -560.
2. Wimalawansa SJ. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin. A peptide superfamily. Grit Rev Neurobiol, 1997, 11:167-239.
3. Jougasaki M, Burnett Jr JC. Adrenomedullin: potential in physiology and pathophysiology. Life Sci, 2000, 66:855-872.
4. Mclatchie LM, Fraser NJ, Main MJ et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 1998, 393:333-339.
5. Clapp LH, Gurney AM. Outward currents in rabbit pulmonary artery cells isolated with a new technique. Exp Physiol, 1991, 76:677-693.
6. Drake WM, Ajayi A, Lowe SR et al. Desensitisation of CGRP and adrenomedullin receptors in SK-N-MC cells: Implications for the RAMP hypothesis. Endocrinology, 1999, 140:533-537.
7. Frasher NJ, Wise A, Brown J et al. The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor. Mol Pharmacol, 1999, 55:1054-1059.
8. Shimosawa T, Ito Y, Ando K et al. Proadrenomedullin NH (2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits nonrepinephrine overflow from nerve endings. J Clin Invest, 1995, 96:1672-1676.
9. 2-terminal 20 peptide has direct vasodilator activity in the cat. Am J Physiol, 1997, 272(4 pt 2):R1047-R1054.
10. Tsuga H, Kameyama K, Haga J et al. Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant negative mutant of GRK2. J Biol Chem, 1994, 269:32522-32527.
11. Freedman NJ, Liggett SB, Drachman DE et al. Phosphorylation and desensitisation of the human β-adrenergic receptor. J Biol Chem, 1995, 270:17953-17961.