Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: Implications for the RAMP hypothesis

Endocrinology

Volumn 140, Issue 1, 1999, Pages 533-537

  Drake, W M ^a   Ajayi, A ^a   Lowe, S R ^a   Mirtella, A ^a   Bartlett, T J ^a   Clark, A J L ^a  

^a Dominion House   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOBUTYLMETHYLXANTHINE; MEMBRANE PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; RAMP PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; HORMONE BINDING; HUMAN; HUMAN CELL; HYPOTHESIS; MEMBRANE TRANSPORT; PEPTIDE ANALYSIS; PRIORITY JOURNAL; RECEPTOR AFFINITY;

1-METHYL-3-ISOBUTYLXANTHINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NEUROBLASTOMA; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, PEPTIDE; TUMOR CELLS, CULTURED;

EID: 0032896189     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.140.1.533     Document Type: Article

References (21)

1. 1. McLatchie LM, Fraser NJ, Main MJ et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 1998; 393: 333-9.
2. 2. Wimalawansa SJ. Calcitonin gene-related peptide, calcitonin, amylin and adrenomedullin: a peptide superfamily. Crit Rev Neurobiol 1997; 11: 167-239.
3. 3. Eguchi S, Hirata Y, Iwasaki H et al. Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinol 1994; 135: 2454-8.
4. 4. Yamaguchi A, Chiba T, Yamatani T et al. Calcitonin gene-related peptide stimulates adenylate cyclase activation via a guanine nucleotide-dependent process in rat liver plasma membranes. Endocrinol 1988; 123: 2591-6.
5. 5. Kapas S, Orford CD, Barker S, Vinson GP, Hinson JP. Studies on the intracellular mechanism of action of alpha-melanocyte-stimulating hormone on rat adrenal zona glomerulosa. J Mol Endocrinol 1992; 9: 47-54.
6. 6. Rosenfeld MG, Mermod JJ, Amara SG et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue specific RNA processing. Nature 1983; 304: 129-35.
7. 7. Kitamura K, Kangawa K, Kawanoto et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192: 553-60.
8. 8. Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology and therapeutic potentials. Endocrine Rev 1996; 17: 533-85.
9. 9. Richards AM, Nicholls MG, Lewis L, Lainchbury JG. Adrenomedullin. Clin Sci 1996; 91: 3-16.
10. 10. Ishizaka Y, Ishizaka Y, Tanaka M et al. Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells. Biochem Biophys Res Commun 1994; 200: 642-6.
11. 11. Upton PD, Austin C, Taylor et al. Expression of adrenomedullin (ADM) and its binding sites in the rat uterus: increased number of binding sites and ADM messenger ribonucleic acid in 20-day pregnant rats compared with nonpregnant rats. Endocrinology (1997); 138: 2508-14.
12. 12. Owji AA, Gardiner JV, Upton PD et al. Characterisation and molecular identification of adrenomedullin binding sites in the rat spinal cord: a comparison with calcitonin gene-related peptide receptors. Journal of Neurochemistry (1996); 67: 2172-9.
13. 13. Han ZQ. Coppock HA. Smith DM. Van Noorden S. Makgoba MW. Nicholl CG. Legon S. The interaction of CGRP and adrenomedullin with a receptor expressed in the rat pulmonary vascular endothelium. J Mol Endocrinol. 1997; 18: 267-72
14. 14. Eguchi S, Hirata Y, Kano H et al. Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett 1994; 340: 226-30.
15. 15. Zimmerman U, Fischer JA Muff R. Adrenomedullin and calcitonin gene-related peptide interact with the same receptor in cultured human neuroblastoma SK-N-MC cells. Peptides (1995) 16: 421-4.
16. 16. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitisation of the human b-adrenergic receptor. J Biol Chem 1995; 270: 17953-61.
17. 17. Tsuga H, Kameyama K, Haga T, Kurose H, Nagao T. Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G-protein coupled receptor kinase (GRK2) and attenuation by a dominant negative mutant of GRK2. J Biol Chem 1994; 269: 32522-27.
18. 18. Barker S, Kapas S, Fluck RJ, Clark AJL. Effects of the selective protein kinase C inhibitor Ro31-7549 on human angiotensin II receptor desensitisation an intracellular calcium release FEBS Lett. 1995; 369: 263-66.
19. 19. Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitisation of β-adrenergic function. FASEB J 1990; 4: 2881-9.
20. 20. Chijiwa T, Mishima A, Hagiwara M et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinoline-sulfonamide (H-89), of PC12D pheochromo-cytoma cells. J Biol Chem 1990; 265: 5267-72.
21. 21. Iwasaki H, Eguchi S, Shichiri M, Marumo F, Hirata Y. Down-regulation of adenylate cyclase coupled to adrenomedullin receptor in vascular smooth muscle cells. Eur J Pharm 1998; 131-4.