Protein-Losing Enteropathy after Fontan Surgery: Is Assessment of Risk Patients with Immunological Data Possible?

Cytometry Part B - Clinical Cytometry

Volumn 53, Issue 1, 2003, Pages 34-39

  Lenz, Dominik ^a   Hambsch, Jörg ^a   Schneider, Peter ^a   Tárnok, Attila ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Cytomics; Prediction; Protein losing enterepathy; T lymphocytes; Univentricular heart

Indexed keywords

CALCIUM ION; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN E; L SELECTIN; PLASMA PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMETRY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FONTAN PROCEDURE; GASTROENTERITIS; GERMANY; HEART SINGLE VENTRICLE; HUMAN; HUMAN CELL; PILOT STUDY; POSTOPERATIVE COMPLICATION; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOSING GASTROENTEROPATHY; RISK ASSESSMENT; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; T LYMPHOCYTE; ADOLESCENT; CHILD; CONGENITAL HEART MALFORMATION; IMMUNOLOGY; IMMUNOPHENOTYPING; PATHOLOGY; PREDICTION AND FORECASTING; PRESCHOOL CHILD; RISK FACTOR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FONTAN PROCEDURE; HEART DEFECTS, CONGENITAL; HUMANS; IMMUNOPHENOTYPING; PILOT PROJECTS; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PROTEIN-LOSING ENTEROPATHIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES;

EID: 1542379107     PISSN: 15524949     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.b.10029     Document Type: Article

References (20)

1. Fontan F, Baudet E. Surgical repair of tricuspid atresia. Thorax 1971;26:240-248.
2. Donnely JP, Rosenthal A, Castle VP, Holmes RD. Reversal of protein-losing enteropathy with heparin therapy in three patients with univentricular hearts and Fontan palliation. J Pediatr 1997;130:474-478.
3. Koch A, Hofbeck M, Feistel H, Buheitel G, Singer H. Circumscribed intestinal protein loss with deficiency in CD4+ lymphocytes after the Fontan procedure. Eur J Pediatr 1999;158:847-850.
4. Mertens L, Hagler DJ, Sauer U, Somerville U, Gewillig M. Protein-losing eneteropathy after the Fontan operation: an international multicentric study. J Thorac Cardiovasc Surg 1998;115:1063-1073.
5. Feldt RH, Driscoll DJ, Offord KP, Cha RH, Perrault J, Schaff HV, Puga FJ, Danielson GK. Protein-losing enteropathy after the Fontan operation. J Thorac Cardiovasc Surg 1996;112:672-680.
6. Garty BZ. Deficiency of CD 4+ lymphocytes due to intestinal loss after Fontan procedure. Eur J Pediatr 2001;160:58-59.
7. Lenz D, Sauer U, Hambsch J, Häusler HJ, Hess J, Schneider P, Tárnok A. Immune alterations following protein-losing enterophathy (PLE) after Glenn/Fontan surgery are similar to those after systemic lupus erythematosus (SLE) and celiac disease (CD): indications for an autoimmune disease [Abstract]. Immunobiology 2000;203:217.
8. Lenz D, Hambsch J, Sauer U, Richter J, Hess U, Schneider P, Tárnok A. Detection of allo- and autoreactive antibodies in patients with protein losing enteropathy (PLE) in Fontan patients by flow and laser scanning cytometry [Abstract]. J Biol Regul Homeost Agents 2001;15:474.
9. Valet G, Tarnok A. Clinical cytomics: predictive medicine and cytometry. Cytometry 2003;53B1-3.
10. Tarnok A, Bocsi J, Pipek M, Osmancik P, Valet G, Schneider P, Hambsch J. Preoperative prediction of postoperative edema and effusion in pediatric cardiac surgery by altered antigen expression patterns of granulocytes and monocytes. Cytometry 2001;46:247-253.
11. Bocsi J, Hambsch J, Osmancik P, Schneider P, Valet G, Tarnok A. Preoperative prediction of pediatric patients with effusion and edema following cardiopulmonary bypass surgery by serological and routine laboratory data. Crit Care 2002;6:226-233.
12. Schmitz G, Rothe G. Durchtlusszytometrie in der klinischen Zelldiagnostik. Stuttgart, Germany: Schattauer Verlag; 1994. p 393-404.
13. Kalmar P, Irrgang E. Cardiac surgery in Germany during 1999. Thorac Cardiovasc Surg 2000;48:XXVII-XXX.
14. Yoshikawa I, Murata I, Tamura M, Kume K, Nakano S, Otsuki M. A case of protein-losing enteropathy caused by acute Helicobacter pylori infection. Gastrointest Endosc 1999;49:245-248.
15. Nakase H, Itani T, Mimura J, Takeuchi R, Kawasaki T, Komori H, Hashimoto K, Chiba T. Transient protein-losing enteropathy associated with a cytomegalovirus infection in a noncompromised host: a case report. Am J Gastroenterol 1998;93:1005-1006.
16. Dansinger ML, Johnson S, Jansen PC, Opstadt NL, Bettin KM, Gerding DN. Protein-losing enteropathy is associated with Clostridium difficile diarrhea but not with asymptomatic colonization: a prospective case control study. Clin Infect Dis 1996;22:932-937.
17. Kretowski A, Mysliwiec J, Kinalska I. Abnormal distribution of gamma delta T lymphocytes in Graves disease and insulin-dependant diabetes type I. Arch Immunol Ther Exp 2000;48:39-42.
18. Cooper GS, Dooley MA, Treadwell EL, St. Clair EW, Gilkeson GSJ. Risk factors for development of systemic lupus erythematosus: allergies, infections and family history. Clin Epidemiol 2002;55:982-989.
19. Lenz D, Hambsch J, Schneider P, Tarnok A. Protein-losing enteropathy in patients with Fontan circulation-is it triggered by infection? Crit Care 2003;7:185-190.
20. Wang J, Whetsell M, Klein JR. Local hormone networks and intestinal T cell homeostasis. Science 1997;275:1937-1939.