Abnormal distribution of γδ T lymphocytes in graves' disease and insulin-dependent diabetes type 1

Archivum Immunologiae et Therapiae Experimentalis

Volumn 48, Issue 1, 2000, Pages 39-42

  Kretowski, Adam ^a   Myśliwiec, Janusz ^a   Kinalska, Ida ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

; Graves' disease; Tcr+ lymphocytes; Type 1 diabetes mellitus

Indexed keywords

ANTITHYROID AGENT; CD3 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; THIAMAZOLE;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; CD8+ T LYMPHOCYTE; FEMALE; GRAVES DISEASE; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; ANTIGENS, CD3; ANTITHYROID AGENTS; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; GRAVES DISEASE; HUMANS; MALE; METHIMAZOLE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS;

EID: 0033628107     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. CATALFAMO M., ROURA-MIR C., SOSPEDRA M., APARICIO P., COSTAGLIOLA S., LUDGATE M., PUJOL-BORRELL R. and JARAQUEMADA D. (1996): Self-reactive cytotoxic γδ T lymphocytes in Graves' disease specifically recognise thyroid epithelial cells. J. Immunol., 156, 804-811.
2. DE LIBERO G. (1997): Sentinel function of broadly reactive human γδ T cells. Immunol. Today, 18, 22-26.
3. GROH V., PORCELLI S. and FABBI M. (1989): Human lymphocytes bearing T cell receptor gamma/delta are phenotipically diverse and evenly distributed throughout the lymphoid system. J. Exp. Med., 169, 1277-1294.
4. HARRISON L. C., DEMPSEY-COLLIER M., KRAMER D. R. and TAKAHASHI K. (1996): Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J. Exp. Med., 184, 2167-2174.
5. HAYDAY A. and GENG L. (1997): γδ Cells regulate autoimmunity. Curr. Opin. Immunol., 9, 884-889.
6. KALLMANN B. A., HUTHER M., TUBES M., FELDKAMP J., BERTRAMS J., GRIES F. A., LAMPETER E. F. and KOLB H. (1997): Systemic bias of cytokine production toward cell-mediated im-mune regulation toward cell-mediated regulation in IDDM and toward humoral immunity in Graves' disease. Diabetes, 46, 237-243.
7. KE Y., PEARCE K., LAKE J. P., ZIEGLER H. K. and KAPP J. A. (1997): γδ T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol., 158, 3610-3618.
8. KEYSTONE E. C., RITTERSHAUS C., WOOD N., SNOW K. M., FLATOW J., PURVIS J. C., POPLONSKI L. and KUNG P. C. (1991): Elevation of a γδ T cell subset in peripheral and synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Immunol., 84, 78-82.
9. KRETOWSKI A., MYŚLIWIEC J., SZELACHOWSKA M., KOWALSKA I., TUROWSKI D., WYSOCKA J. and KINALSKA I. (1999): γδ T cells alterations in the peripheral blood of high risk diabetes type 1 subjects with subclinical pancreatic B-cells impairment. Immunol. Lett., 68, 289-293.
10. OLIVE C., GATENBY P. A. and SERJEANTSON S. W. (1994): Restricted junctional diversity of T cell receptor δ gene rearrangements expressed in systemic lupus erythematosus (SLE) patients. Clin. Exp. Immunol., 97, 430-438.
11. OSUGI Y., HARA J., KURAHASHI H., SAKATA N., INOUE M., YUMURA-YAGI K., KAWA-HA K., OKADA S. and TAWA A. (1995): Age-related changes in surface antigens on peripheral lymphocytes of healthy children. Clin. Exp. Immunol., 100, 543-548.
12. RAULET D. H. (1999): Does a low level of expression of HLA molecules engender autoimmunity? N. Engl. J. Med., 340, 314-315.
13. ROURA-MIR C., VARGAS A. F., TOLOSA E., OBIOLS G., FOZ M., JARAQUEMADA D. and PUJOL-BORRELL R. (1993): γδ T lymphocytes in endocrine autoimmunity: evidence of expansion in Graves' disease but not in type 1 diabetes. Clin. Exp. Immunol., 92, 288-295.
14. SASIAN S., ROJANO J., GAVILAN I., AGUILAR M., ESCOBAR L. and GIRON J. A. (1998): Serial analysis of circulating T gamma/delta lymphocyte subpopulations in Graves' disease. Endocrinol. Res., 24, 285-295.
15. STINISSEN P., VANDEVYVER C., MEDAER R., VANDEGAER L., NIES J., TUYLS L., HAFLER D. A., RAUS J. and ZHANG J. (1995): Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity and T cell receptor V gene rearrangements. J. Immunol., 154, 4883-4894.
16. TENG W. P., CHEN S. B., POSNETT D. N. and WEETMAN A. P. (1990): T cell receptor phenotypes in autoimmune thyroid disease. J. Endocrinol. Invest., 13, 339-342.
17. TRONCONE R., GRECO L., MAYER M., PAPARO F., CAPUTO N., MICILLO M., MUGIONE P. and AURICCHIO S. (1996): Latent and potential coeliac disease. Acta. Paediatr. Suppl., 412, 10-14.