Synthesis and biological evaluation of 6-substituted purine and 9-β-D-ribofuranosyl purine analogues

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 6, 2004, Pages 1425-1429

  Wang, Jun Feng ^a   Zhang, Liang Ren ^a   Yang, Zhen Jun ^a   Zhang, Li He ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

3,4 dihydro 2H pyran; CD; Circular dichroism spectrum; CSA; D(+) 10 Camphorsulfonic acid; Deoxyribonucleic acid; DHP; Dimethyl sulfoxide; Dimethylformamide; DMF; DMSO; DNA; Hexamethylphosphorous triamide; HMPT; NMR; Nuclear magnetic resonance; Ribonucleic acid; RNA

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DOUBLE STRANDED RNA; FURANONE DERIVATIVE; NUCLEOSIDE; PURINE DERIVATIVE; RIBOSE; RNA; SUGAR;

AQUEOUS SOLUTION; ARTICLE; CANCER INHIBITION; CELL LINE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; MELTING POINT; MOLECULAR INTERACTION; RNA BINDING; STRUCTURE ANALYSIS; THERMODYNAMICS;

CELL DIVISION; CIRCULAR DICHROISM; DNA; FORMAZANS; HELA CELLS; HL-60 CELLS; HUMANS; NUCLEIC ACID CONFORMATION; PURINE NUCLEOSIDES; RNA; SOLUTIONS; TETRAZOLIUM SALTS;

EID: 1542361434     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.005     Document Type: Article

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25. In this paper, the structural positions of 6-substituted purine and 9-β-D-ribofuranosyl purine analogues are numbered as follows: for the 6-substituted purine, a single prime numbering scheme is used for the position of 6-side chain of purine; for the 6-substituted 9-β-D-ribofuranosyl purine, a single prime numbering scheme is used for the position of 6-side chain of purine and a double prime numbering scheme is used for the position of the N-9 ribosyl moiety.