Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice

Journal of Clinical Investigation

Volumn 109, Issue 4, 2002, Pages 541-548

  Hodgin, Jeffrey B ^a   Knowles, Joshua W ^a   Kim, Hyung Suk ^a   Smithies, Oliver ^a   Maeda, Nobuyo ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; APOLIPOPROTEIN E; ESTROGEN; NITRIC OXIDE SYNTHASE; RENIN; SEX HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; FEMALE; GENOTYPE; GONADECTOMY; HYPERTENSION; LIPID ANALYSIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036181064     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214066     Document Type: Article

References (39)

1. Gender differences in the regulation of blood pressure
2. Postmenopausal hormone replacement therapy and cardiovascular disease
3. Hormone replacement therapy and cardiovascular disease: A statement for healthcare professionals from the American Heart Association
4. The cardiac toxicity of anabolic steroids
5. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms
6. Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice
7. Effect of 17 beta estradiol on aortic cholesterol content and metabolism in cholesterol-fed rabbits
8. Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys
9. 17 beta-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice
10. Oestrogen attenuates the increases in blood pressure and platelet aggregation in ovariectomized and salt-loaded Dahl salt-sensitive rats
11. Natural androgens inhibit male atherosclerosis: A study in castrated, cholesterol-fed rabbits
12. Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
13. Hormone therapy to prevent disease and prolong life in postmenopausal women
14. The protective effects of estrogen on the cardiovascular system
15. Estrogens and atherosclerosis
16. Differing responses in blood pressure over 24 hours in normotensive women receiving oral or transdermal estrogen replacement therapy
17. Estradiol with or without progesterone and ambulatory blood pressure in postmenopausal women
18. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
19. Elevated blood pressures in mice lacking endothelial nitric oxide synthase
20. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase
21. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
22. -/- mice are ameliorated by enalapri treatment
23. Estrogen modulates responses of atherosclerotic coronary arteries
24. Induction of calcium-dependent nitric oxide synthases by sex hormones
25. Significant reduction of the antiatherogenic effect of estrogen by long-term inhibition of nitric oxide synthesis in cholesterol-clamped rabbits
26. Prevention of fatty streak formation of 17beta-estradiol is not mediated by the production of nitric oxide in apolipoprotein E-deficient mice
27. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
28. A non-invasive computerized tail-cuff system for measuring blood pressure in mice
29. Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice
30. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice
31. -/- mice
32. Angiotensin-converting enzyme gene and atherosclerosis
33. Vascular endothelial growth factor is modulated in vascular muscle cells by estradiol, tamoxifen, and hypoxia
34. Vascular endothelial growth factor enhances atherosclerotic plaque progression
35. Estrogen, natriuretic peptides and the renin-angiotensin system
36. Genetic modifiers of atherosclerosis in mice
37. Hemodynamic changes in apolipoprotein E-knockout mice
38. Perspective: Non-reproductive sites of action of reproductive hormones
39. Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells