3′ UTR (AGG)n repeat of glial cell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia

Neuroscience Letters

Volumn 357, Issue 3, 2004, Pages 235-237

  Michelato, Anna ^a   Bonvicini, Cristian ^a   Ventriglia, Mariacarla ^a   Scassellati, Catia ^a   Randazzo, Roberto ^a   Bignotti, Stefano ^a   Beneduce, Rossella ^a   Riva, Marco Andrea ^b   Gennarelli, Massimo ^a,c  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Association study; Italian population; Neurotrophic factor; Protective factors

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; REPETITIVE DNA; GDNF PROTEIN, HUMAN; NERVE GROWTH FACTOR; RNA;

3' UNTRANSLATED REGION; ADULT; AGED; ALLELE; ARTICLE; BRAIN REGION; CELL LINE; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; SCHIZOPHRENIA; SCHOOL CHILD; BIOSYNTHESIS; BLOOD; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; ITALY; METHODOLOGY; MIDDLE AGED; POLYMERASE CHAIN REACTION; TRINUCLEOTIDE REPEAT;

3' UNTRANSLATED REGIONS; ADULT; AGED; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; ITALY; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RNA; SCHIZOPHRENIA; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 1542345648     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.12.089     Document Type: Article

References (19)

1. Arimondo P.B., Barcelo F., Sun J.S., Maurizot J.C., Garestier T., Melene C. Triple Helix formation by (G,A)-containing oligonucleotides: asymmetric sequence effect. Biochemistry. 37:1998;16627-16635.
2. Bayer T.A., Falkai P. Schizophrenia a subtle defect in neurotrophic gene function? Neurol. Psychiatry Brain Res. 5:1997;151-156.
3. Bourque M.J., Trudeau L.E. GDNF enhances the synaptic efficacy of dopaminergic neurons in culture. Eur. J. Neurosci. 12:2000;3172-3180.
4. Conne B., Stutz A., Vassalli J.D. The 3′ untranslated region of messenger RNA: a molecular 'hotspot' for pathology? Nat. Med. 6:2000;637-641.
5. Granholm A.C., Reyland M., Albeck D., Sanders L., Gerhardt G., Hoernig G., Shen L., Westphal H., Hoffer B. Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. J. Neurosci. 20:2000;3182-3190.
6. Grimm L., Holinski-Feder E., Teodoridis J., Scheffer B., Schindelhauer D., Meitinger T., Ueffing M. Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3′-UTR and alternative splice products. Hum. Mol. Genet. 7:1998;1873-1886.
7. Lee K., Kunugi H., Nanko S. Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysis. Psychiatry Res. 104:2001;11-17.
8. Moises H.W., Zoega T., Gottesman I.I. The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia. B.M.C. Psychiatry. 2:2002;8.
9. Murray R.M. Neurodevelopmental schizophrenia: the rediscovery of dementia precox. Br. J. Psychiatry. 25:1994;6-12.
10. Pierce R.C., Bari A.A. The role of neurotrophic factors in psychostimulant-induced behavioral and neuronal plasticity. Rev. Neurosci. 12:2001;95-110.
11. Prasad S., Semwal P., Deshpande S., Bhatia T., Nimgaonkar V.L., Thelma B.K. Molecular genetics of schizophrenia: past, present and future. J. Biosci. 27:2002;35-52.
12. Quandt K., Frech K., Karas H., Wingender E., Werner T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23:1995;4878-4884.
13. Schindelhauer D., Schuffenhauer S., Gasser T., Steinkasserer A., Meitinger T. The gene coding for glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1. Genomics. 28:1995;605-607.
14. S. Schneider, D. Roessli, and L. Excofier, Arlequin: a software for population genetics data analysis. Ver 2.000, Genetics and Biometry Lab, Dept of Anthropology, University of Geneva, 2000.
15. Sham P., Curtis D. Monte Carlo tests for associations between disease and alleles at high polymorphic loci. Ann. Hum. Genet. 59:1995;97-105.
16. Thome J., Foley P., Riederer P. Neurotrophic factors and the maldevelopmental hypothesis of schizophrenic psychoses. J. Neural Transm. 105:1998;85-100.
17. Weinberger D.R. From neuropathology to neurodevelopment. Lancet. 346:1995;552-557.
18. Wingender E., Chen X., Fricke E., Geffers R., Hehl R., Liebich I., Krull M., Matys V., Michael H., Ohnhauser R., Pruss M., Schacherer F., Thiele S., Urbach S. The TRANSFAC system on gene expression regulation. Nucleic Acids Res. 29:2001;281-283.
19. Woods B.T. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am. J. Psychiatry. 155:1998;1661-1667.