QSPR/QSAR in N-[(dimethylamine)methyl] benzamides substituents groups influence upon electronic distribution and local anesthetics activity

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 6, 2004, Pages 1377-1381

  Tavares, Leoberto Costa ^a   Do Amaral, Antonia Tavares ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

C=O IR spectroscopy; Electronic parameter; Electronic substituent groups effects; Hammett equation; Local anesthetical activity; Procainamide analogues; QSPR QSAR

Indexed keywords

BENZAMIDE DERIVATIVE; LOCAL ANESTHETIC AGENT;

ABSORPTION; ARTICLE; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG POTENCY; FEMALE; INFRARED RADIATION; LOCAL ANESTHESIA; NONHUMAN; POLARIZATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ANESTHETICS, LOCAL; ANIMALS; BENZAMIDES; CENTRAL NERVOUS SYSTEM; DIMETHYLAMINES; ELECTRONS; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, WISTAR;

EID: 1542331637     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.011     Document Type: Article

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