A Kinesin-like Motor Inhibits Microtubule Dynamic Instability

Science

Volumn 303, Issue 5663, 2004, Pages 1519-1522

  Bringmann, Henrik ^a,b   Skiniotis, Georgios ^a,c   Spilker, Annina ^a,d   Kandels Lewis, Stefanie ^a   Vernos, Isabelle ^a   Surrey, Thomas ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; CYTOLOGY;

MICROTUBULES; MOLECULAR MOTORS;

ENZYMES;

KINESIN; KINESIN LIKE PROTEIN 1; MOLECULAR MOTOR; PROTEIN; UNCLASSIFIED DRUG;

NANOTECHNOLOGY;

ANIMAL EXPERIMENT; ARTICLE; CELL MOTILITY; CHROMOSOME; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANIMALS; CENTROSOME; CHROMOSOMES; CRYOELECTRON MICROSCOPY; DIMERIZATION; KINETICS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MOLECULAR MOTOR PROTEINS; PACLITAXEL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TUBULIN; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA; XENOPUS LAEVIS;

EID: 1542317579     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094838     Document Type: Article

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33. We thank M. Utz for technical assistance, N. Mücke (DKFZ, Heidelberg) for help with the analytical ultracentrifugation, G. Tsiavaliaris (Max Planck Institute for Medical Research, Heidelberg) for help with the stopped-flow measurements, A. Hoenger and T. Wendt for help with the cryo-EM, R. Cross (Marie Curie Research Institute, Oxted) for pET17bGST, A. Popov and F. Nédélec for centrosomes, and I. Arnal (CNRS, Rennes) for axonemes. Supported by DFG grant SU 175/4-1. H.B. was supported by the German National Merit Foundation.