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Volumn 16, Issue 1-2, 2004, Pages 73-91

Application of PBPK model for 2,4-D to estimates of risk in backpack applicators

Author keywords

2,4 D; Backpack; Exposure; Flow limited; Herbicides; Model; PBPK; pH trapping; Weak acids; Worker

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID;

EID: 1542316263     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2003.09.003     Document Type: Article
Times cited : (8)

References (42)
  • 2
    • 0012430353 scopus 로고    scopus 로고
    • Oxford Science Park, Oxford OX4 4GA, United Kingdom
    • Cherwell Scientific Limited, 2000. ModelMaker User Manual. Version 4. Oxford Science Park, Oxford OX4 4GA, United Kingdom, available at: http://www.modelkinetix.com.
    • (2000) ModelMaker User Manual. Version 4
  • 3
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies B., Morris T. Physiological parameters in laboratory animals and humans. Pharma. Res. 10:1993;1093.
    • (1993) Pharma. Res. , vol.10 , pp. 1093
    • Davies, B.1    Morris, T.2
  • 4
    • 0022654086 scopus 로고
    • Nephrotoxicity of cyclosporine A. a lithium clearance and micropuncture study
    • Dieperink H.et al. Nephrotoxicity of cyclosporine A. A lithium clearance and micropuncture study. Eur. J. Clin. Invest. 16:1986;69.
    • (1986) Eur. J. Clin. Invest. , vol.16 , pp. 69
    • Dieperink, H.1
  • 5
    • 0023370667 scopus 로고
    • Cyclosporine-induced acute renal dysfunction in the rat
    • English J.et al. Cyclosporine-induced acute renal dysfunction in the rat. Transplant. 44:1987;135.
    • (1987) Transplant , vol.44 , pp. 135
    • English, J.1
  • 6
    • 0016373013 scopus 로고
    • Percutaneous penetration of some pesticides and herbicides in man
    • Feldmann R.J., Maibach H.I. Percutaneous penetration of some pesticides and herbicides in man. Toxicol. Appl. Pharmacol. 28:1974;126.
    • (1974) Toxicol. Appl. Pharmacol. , vol.28 , pp. 126
    • Feldmann, R.J.1    Maibach, H.I.2
  • 7
    • 0024336241 scopus 로고
    • HPLC measurement of chlorophenoxy herbicides, bromoxynil, and ioxynil, in biological specimens to aid diagnosis of acute poisoning
    • Flanagan R.J., Ruprah M. HPLC measurement of chlorophenoxy herbicides, bromoxynil, and ioxynil, in biological specimens to aid diagnosis of acute poisoning. Clin. Chem. 35:1989;1342.
    • (1989) Clin. Chem. , vol.35 , pp. 1342
    • Flanagan, R.J.1    Ruprah, M.2
  • 8
    • 0023425857 scopus 로고
    • Acute, pharmacokinetic, and subchronic toxicological studies of 2,4-dichlorophenoxyacetic acid
    • Gorzinski S.J.et al. Acute, pharmacokinetic, and subchronic toxicological studies of 2,4-dichlorophenoxyacetic acid. Fund. Appl. Toxicol. 9:1987;423.
    • (1987) Fund. Appl. Toxicol. , vol.9 , pp. 423
    • Gorzinski, S.J.1
  • 9
    • 0003444170 scopus 로고
    • Recommendations of the International Commission on Radiological Protection (ICRP). Publication No. 23, Pergamon Press, New York, NY.
    • ICRP (International Commission on Radiologic Protection), 1975. Report of the Task Group on Reference Man. Recommendations of the International Commission on Radiological Protection (ICRP). Publication No. 23, Pergamon Press, New York, NY.
    • (1975) Report of the Task Group on Reference Man
  • 10
    • 0003738717 scopus 로고
    • Report prepared under a cooperative agreement with US EPA, Office of Health and Environmental Assessment, December 1994, Available from ILSI Risk Science Institute via an e-mail request to rsi@ilsi.org
    • ILSI (International Life Sciences Institute), 1994. Physiological Parameter Values for PBPK Models. Report prepared under a cooperative agreement with US EPA, Office of Health and Environmental Assessment, December 1994, Available from ILSI Risk Science Institute via an e-mail request to rsi@ilsi.org.
    • (1994) Physiological Parameter Values for PBPK Models
  • 11
    • 0033030726 scopus 로고    scopus 로고
    • Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats
    • Keys D.A.et al. Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats. Toxicol. Sci. 49:1999;172.
    • (1999) Toxicol. Sci. , vol.49 , pp. 172
    • Keys, D.A.1
  • 12
    • 0028890397 scopus 로고
    • Development of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid (2,4-D) dosimetry in discrete areas of rabbit brain
    • Kim C.S.et al. Development of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid (2,4-D) dosimetry in discrete areas of rabbit brain. Neurotoxicol. Teratol. 17:1995;111.
    • (1995) Neurotoxicol. Teratol. , vol.17 , pp. 111
    • Kim, C.S.1
  • 14
    • 0015748952 scopus 로고
    • Binding of 2,4-dichloro- and 2,4,5-trichlorophenoxyacetic acid to bovine serum albumin
    • (Copenhagen)
    • Kolberg J.et al. Binding of 2,4-dichloro- and 2,4,5- trichlorophenoxyacetic acid to bovine serum albumin. Acta Pharmacol. Toxicol. 33:1973;470. (Copenhagen).
    • (1973) Acta Pharmacol. Toxicol. , vol.33 , pp. 470
    • Kolberg, J.1
  • 15
    • 0018419310 scopus 로고
    • Transport of 2,4,5-trichlorophenoxyacetate in the isolated, perfused rat kidney
    • Koschier F.J., Acara M. Transport of 2,4,5-trichlorophenoxyacetate in the isolated, perfused rat kidney. J. Pharmacol. Exp. Ther. 208:1979;287.
    • (1979) J. Pharmacol. Exp. Ther. , vol.208 , pp. 287
    • Koschier, F.J.1    Acara, M.2
  • 16
    • 0017251823 scopus 로고
    • In vitro uptake of organic ions by renal cortical tissue of rats treated acutely with 2,4,5-trichlorophenoxyacetic acid
    • Koschier F., Berndt W.O. In vitro uptake of organic ions by renal cortical tissue of rats treated acutely with 2,4,5-trichlorophenoxyacetic acid. Toxicol. Appl. Pharmacol. 35:1976;355.
    • (1976) Toxicol. Appl. Pharmacol. , vol.35 , pp. 355
    • Koschier, F.1    Berndt, W.O.2
  • 17
    • 0019796552 scopus 로고
    • Effect of 2,4,5-trichlorophenoxyacetate on renal function
    • Koschier F.J., Hong S.K. Effect of 2,4,5-trichlorophenoxyacetate on renal function. Food Cosmet. Toxicol. 19:1981;189.
    • (1981) Food Cosmet. Toxicol. , vol.19 , pp. 189
    • Koschier, F.J.1    Hong, S.K.2
  • 18
    • 0002252728 scopus 로고
    • Physiologically based pharmacokinetic modeling of chemical mixtures
    • R.S.H. Yang (Ed.), Academic Press, New York, NY
    • Krishnan, K., et al., 1994. Physiologically based pharmacokinetic modeling of chemical mixtures. In: R.S.H. Yang (Ed.), Toxicology of Chemical Mixtures. Academic Press, New York, NY, p. 399.
    • (1994) Toxicology of Chemical Mixtures , pp. 399
    • Krishnan, K.1
  • 20
    • 38249038465 scopus 로고
    • Exposure of forestry ground workers to 2,4-D, picloram, and dichlorprop
    • Lavy T.L.et al. Exposure of forestry ground workers to 2,4-D, picloram, and dichlorprop. Environ. Toxicol. Chem. 6:1987;209.
    • (1987) Environ. Toxicol. Chem. , vol.6 , pp. 209
    • Lavy, T.L.1
  • 21
    • 0021073185 scopus 로고
    • Morphological findings in kidney transplants afer treatment with cyclosporine
    • Mihatsch M.J.et al. Morphological findings in kidney transplants afer treatment with cyclosporine. Transplant. Proc. 15:1983;2821.
    • (1983) Transplant. Proc. , vol.15 , pp. 2821
    • Mihatsch, M.J.1
  • 22
    • 0026718565 scopus 로고
    • Dermal absorption of the phenoxy herbicide 2,4-D dimethylamine in humans
    • Moody R.P.et al. Dermal absorption of the phenoxy herbicide 2,4-D dimethylamine in humans. J. Toxicol. Environ. Health. 36:1992;241.
    • (1992) J. Toxicol. Environ. Health , vol.36 , pp. 241
    • Moody, R.P.1
  • 24
    • 0018882015 scopus 로고
    • Observations on the 2,4-diclorophenoxyacetic acid (2,4-D) excretion in the goat
    • Oberg J. Observations on the 2,4-diclorophenoxyacetic acid (2,4-D) excretion in the goat. Acta Pharmacol. Toxicol. 46:1980;78.
    • (1980) Acta Pharmacol. Toxicol. , vol.46 , pp. 78
    • Oberg, J.1
  • 25
    • 0026533396 scopus 로고
    • A physiologically based kinetic model of rat and mouse gestation: Disposition of a weak acid
    • O'Flaherty E.J.et al. A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. Toxicol. Appl. Pharmacol. 112:1992;245.
    • (1992) Toxicol. Appl. Pharmacol. , vol.112 , pp. 245
    • O'Flaherty, E.J.1
  • 26
    • 0011353989 scopus 로고
    • Health Canada, US Environmental Protection Agency, and American Crop Protection Association.
    • PHED Task Force, 1995. PHED: The Pesticide Handlers Exposure Database. Version 1.1. Health Canada, US Environmental Protection Agency, and American Crop Protection Association.
    • (1995) PHED: The Pesticide Handlers Exposure Database. Version 1.1
  • 27
    • 0029144723 scopus 로고
    • An algorithm for predicting tissue:blood partition coefficients of organic chemicals from n-octanol:water partition coefficient data
    • Poulin P., Krishnan K. An algorithm for predicting tissue:blood partition coefficients of organic chemicals from n-octanol:water partition coefficient data. J. Toxicol. Environ. Health. 46:1995;117.
    • (1995) J. Toxicol. Environ. Health , vol.46 , pp. 117
    • Poulin, P.1    Krishnan, K.2
  • 28
    • 18544374144 scopus 로고
    • Simulated annealing methods, Section 10.9
    • (third reprint with corrections). Cambridge University Press, Cambridge, UK.
    • Press, W.H., et al., 1995. Simulated annealing methods, Section 10.9. In: Numerical Recipes in C: The Art of Scientific Computing, second ed. (third reprint with corrections). Cambridge University Press, Cambridge, UK. p. 994.
    • (1995) Numerical Recipes in C: The Art of Scientific Computing, Second Ed. , pp. 994
    • Press, W.H.1
  • 29
    • 0002635147 scopus 로고
    • Glomerular filtration
    • Orloff, J., Berliner, R.W., Geriger, S.R. (Eds.), American Physiological Society, Washington, DC
    • Renkin, E.M., Gilmore, J.P., 1973. Glomerular filtration. In: Orloff, J., Berliner, R.W., Geriger, S.R. (Eds.), Handbook of Physiology. Section 8. Renal Physiology. American Physiological Society, Washington, DC, p. 229.
    • (1973) Handbook of Physiology. Section 8. Renal Physiology , pp. 229
    • Renkin, E.M.1    Gilmore, J.P.2
  • 30
    • 0017640555 scopus 로고
    • The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man
    • Sauerhoff M.W.et al. The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man. Toxicology. 8:1977;3.
    • (1977) Toxicology , vol.8 , pp. 3
    • Sauerhoff, M.W.1
  • 32
    • 1542354457 scopus 로고
    • Project No. 2184-102 Final Report. Unpublished study received 14 October 1983 under unknown admin. no. Prepared by Hazleton Laboratories America, by 2 4-D Task Force, Washington, DC, CDL:251474-A, MRID No. 00131304.
    • Serota, D., et al., 1983. Subchronic Toxicity Study in Rats - 2,4-Dichloro-Phenoxyacetic Acid (2,4-D). Project No. 2184-102 Final Report. Unpublished study received 14 October 1983 under unknown admin. no. Prepared by Hazleton Laboratories America, by 2 4-D Task Force, Washington, DC, CDL:251474-A, MRID No. 00131304.
    • (1983) Subchronic Toxicity Study in Rats - 2,4-Dichloro-Phenoxyacetic Acid (2,4-D)
    • Serota, D.1
  • 33
    • 1542294429 scopus 로고
    • Oxford University Press, New York
    • Smith, H.W., 1951. The Kidney. Oxford University Press, New York, p. 60.
    • (1951) The Kidney , pp. 60
    • Smith, H.W.1
  • 34
    • 0005611478 scopus 로고
    • Dow Chemical USA, R&D Report HET K-002372-(24) dated 9 December 1980, Copy courtesy of Dr. Joseph Dybowski, Dow Chemical.
    • Smith, F.A., et al., 1980. Pharmacokinetics of 2,4-Dichlorophenoxyacetic Acid in Fisher 344 Rats. Dow Chemical USA, R&D Report HET K-002372-(24) dated 9 December 1980, Copy courtesy of Dr. Joseph Dybowski, Dow Chemical.
    • (1980) Pharmacokinetics of 2,4-Dichlorophenoxyacetic Acid in Fisher 344 Rats
    • Smith, F.A.1
  • 35
    • 0022389278 scopus 로고
    • Cyclosporin nephrotoxicity: Studies in laboratory animals
    • Sullivan B.A.et al. Cyclosporin nephrotoxicity: studies in laboratory animals. Transplant Proc. 17:1985;145.
    • (1985) Transplant Proc. , vol.17 , pp. 145
    • Sullivan, B.A.1
  • 36
    • 0030569580 scopus 로고    scopus 로고
    • Interaction of 2,4-dichlorophenoxyacetic acid (2,4-D) with cell and model membranes
    • Suwalsky M.et al. Interaction of 2,4-dichlorophenoxyacetic acid (2,4-D) with cell and model membranes. Biochem. Biophys. Acta. 1285:1996;267.
    • (1996) Biochem. Biophys. Acta , vol.1285 , pp. 267
    • Suwalsky, M.1
  • 37
    • 0021082314 scopus 로고
    • Physiologically based pharmacokinetic model for β-lactam antibiotics. I. Tissue distribution and elimination in rats
    • Tsuji A.et al. Physiologically based pharmacokinetic model for β-lactam antibiotics. I. Tissue distribution and elimination in rats. J. Pharmaceut. Sci. 72:1983;1239.
    • (1983) J. Pharmaceut. Sci. , vol.72 , pp. 1239
    • Tsuji, A.1
  • 38
    • 1542294432 scopus 로고    scopus 로고
    • Integrated Risk Information System (IRIS). National Center for Environmental Assessment, Washington, DC
    • US EPA. 2002. Integrated Risk Information System (IRIS). National Center for Environmental Assessment, Washington, DC, online http://www.epa.gov/iris.
    • (2002)
  • 39
    • 0025176640 scopus 로고
    • Acute effects of intravenous cyclosporine on blood pressure, renal hemodynamics, and urine prostaglandin production of healthy humans
    • Weir M.R.et al. Acute effects of intravenous cyclosporine on blood pressure, renal hemodynamics, and urine prostaglandin production of healthy humans. Transplant. 49:1990;41.
    • (1990) Transplant , vol.49 , pp. 41
    • Weir, M.R.1
  • 40
    • 0020039163 scopus 로고
    • Experimental cyclosporine a nephrotoxicity
    • Whiting P.H.et al. Experimental cyclosporine A nephrotoxicity. Br. J. Exp. Pathol. 63:1982;88.
    • (1982) Br. J. Exp. Pathol. , vol.63 , pp. 88
    • Whiting, P.H.1
  • 41
    • 0020634483 scopus 로고
    • Pathological changes in rats receiving cyclosporin a at immunotherapeutic dosage for 7 weeks
    • Whiting P.H. Pathological changes in rats receiving cyclosporin A at immunotherapeutic dosage for 7 weeks. B. J. Exp. Pathol. 64:1983;437.
    • (1983) B. J. Exp. Pathol. , vol.64 , pp. 437
    • Whiting, P.H.1
  • 42
    • 0025061669 scopus 로고
    • Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats
    • Ylitalo P.et al. Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats. Gen. Pharma. 21:1990;811.
    • (1990) Gen. Pharma. , vol.21 , pp. 811
    • Ylitalo, P.1


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