Identification and Purity Control of Thioacridine Derivatives by Gas and Capillary Liquid Chromatography with Mass Spectrometric Detection

Analytical Letters

Volumn 37, Issue 2, 2004, Pages 263-272

  Kutnerová, Blanka ^a   Jelínek, Ivan ^a   Štícha, Martin ^a   Němcová, Irena ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Capillary liquid chromatography; Gas chromatography; Mass spectrometry; Thioacridine derivatives

Indexed keywords

ACRIDINE DERIVATIVE; THIOACRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY CHROMATOGRAPHY; DEGRADATION; ELECTRON; ELECTROSPRAY MASS SPECTROMETRY; GAS CHROMATOGRAPHY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PURIFICATION; SYNTHESIS;

EID: 1542316074     PISSN: 00032719     EISSN: None     Source Type: Journal    
DOI: 10.1081/AL-120027791     Document Type: Article

References (9)

1. Chauhan, P.M.S.; Srivastava, S.K. Present trends and future strategy in chemotherapy of malaria. Curr. Med. Chem. 2001, 8, 1535-1542.
2. Hunter, W.N.; Bailey, S.; Habash, J.; Harrop, S.J.; Helliwell, J.R.; Aboagye-Kwarteng, T.; Smith, K.; Fairlamb, A.H. Active-site of trypanothione reductase-a target for rational drug design. J. Mol. Biol. 1992, 227, 322-333.
3. Lantwin, C.B.; Schlichting, S.J.; Kabsch, W.; Pai, E.F. The structure of trypanosoma-cruzi trypanothione reductase in the oxidized and NADPH reduced-state. Proteins 1994, 18, 161-173.
4. Stoll, V.S.; Simpson, S.J.; Krauth-Siegel, R.L.; Walsh, C.T.; Pai, E.F. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry 1997, 36, 6437-6447.
5. Gallwitz, H.; Bonse, S.; Martinez-Cruz, A.; Schlichting, I.; Schumacher, K.; Krauth-Siegel, R.L. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. J. Med. Chem. 1999, 42 (3), 364-372.
6. Jurlina, J.R.; Paxton, J.W. High-performance liquid-chromatographic method for the determination of 4′ -(9-acridinylamino)methansulfonmeta-anisidide in plasma. J. Chromatogr. 1983, 276, 367-374.
7. Jurlina, J.R.; Paxton, J.W. Determination of N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenylamino] -4-acridinecarboxamide in plasma by high-performance liquid-chromatography. J. Chromatogr. B 1985, 342, 431-435.
8. Matalová, R.; Jelínek, I.; Pumera, M.; Barbe, J. Capillary zone electrophoretic assay of biologically active thioacridine derivatives. J. Sep. Sci. 2003, 26, 129-132.
9. Coufal, P.; Bosáková, Z.; Tesařová, B.; Kafková, B.; Suchnáková, J.; Barbe, J. Quantification and purity determination of newly synthesized thioacridines by capillary liquid chromatography. J. Chromatogr. B 2002, 770, 183-189.