Chirality effect of C-20 on metabolism of methyl 11β,17α,20- trihydroxy-3-oxo-1,4-pregnadien-21-oate derivatives

Steroids

Volumn 69, Issue 2, 2004, Pages 87-91

  Park, Kwan Kyun ^a   Ko, Dong Hoon ^a   You, Zhengqing ^a   Cooperwood, John S ^a   Park, Jonghan ^a   Lee, Henry Joung ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

Antedrugs; Anti inflammatory agents; Chirality; Drug design; Hydrolysis; Steroids

Indexed keywords

11BETA,17ALPHA,20ALPHA TRIHYDROXY 3 OXO 1,4 PREGNADIEN 21 OATE; ACETONIDE DERIVATIVE; CARBON; CARBONIC ACID DERIVATIVE; ESTER DERIVATIVE; ESTERASE; FLUORINE DERIVATIVE; METHYL 11BETA,17ALPHA,20ALPHA TRIHYDROXY 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20ALPHA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20ALPHA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 CARBONATE; METHYL 11BETA,17ALPHA,20BETA TRIHYDROXY 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20BETA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20BETA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 CARBONATE; PREGNANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL BOND; CHIRALITY; CONTROLLED STUDY; DRUG HYDROLYSIS; ENZYME INHIBITION; EPIMER; HALF LIFE TIME; ISOMER; LIVER HOMOGENATE; MALE; METABOLISM; MOLECULAR MODEL; NONHUMAN; PLASMA; RAT; STEREOSPECIFICITY; STEROIDOGENESIS; STRUCTURE ANALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD; DRUG DESIGN; DRUG STABILITY; ESTERASES; HALF-LIFE; HYDROLYSIS; LIVER; MODELS, MOLECULAR; PREDNISOLONE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1542315630     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2003.10.002     Document Type: Article

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