Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and FcγRII-mediated B cell suppression

Journal of Experimental Medicine

Volumn 195, Issue 8, 2002, Pages 1079-1085

  Rudge, Elizabeth U ^a   Cutler, Antony J ^a   Pritchard, Nicholas R ^a   Smith, Kenneth G C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

B cells; CD22; Fc RII; Inhibitory receptors; Interleukin 4

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD22 ANTIGEN; CD32 ANTIGEN; CD72 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN G; INTERLEUKIN 4; MESSENGER RNA;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; T LYMPHOCYTE; TH2 CELL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD22; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; CALCIUM; CELL ADHESION MOLECULES; GENE EXPRESSION; HUMANS; INTERLEUKIN-4; INTRACELLULAR FLUID; LECTINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGG; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0037089624     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011435     Document Type: Article

References (30)

1. Immune inhibitory receptors
2. Hyperresponsive B cells in CD22-deficient mice
3. Augmented Immoral and anaphylactic responses in Fc gamma RII-deficient mice
4. CD72, a negative regulator of B-cell responsiveness
5. Receptor modulators of BCR signalling - CD19/22
6. Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: Innate recognition of self to dampen autoreactivity?
7. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B
8. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells
9. Deficiency in CD22, a B cell-specific inhibitory-receptor, is sufficient to predispose to development of high affinity autoantibodies
10. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis
11. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRlI
12. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice
13. Genetic dissection of vasculitis in MRL/Ipr lupus mice: A novel susceptibility locus involving the CD72c allele
14. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
15. The IL-4 receptor: Signaling mechanisms and biologic functions
16. Regulation of cell morphology in B lymphocytes by IL-4: Evidence for induced cytoskeletal changes
17. B cell growth-promoting activity of recombinant human interleukin 4
18. + T cell population to the T helper 2 cell pathway
19. IL-4 induces loss of B lymphocyte Fc gamma R II ligand binding capacity
20. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6
21. Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB
22. Characterization of the expression and gene promoter of CD22 in murine B cells
23. Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice
24. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
25. B-cell-stimulatory factor 1 reverses Fc receptor-mediated inhibition of B-lymphocyte activation
26. Regulation of B cell receptor-mediated MHC class II antigen processing by FcgammaRIIB1
27. Inhibition of the B cell by CD22: A requirement for Lyn
28. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP
29. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
30. Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice