Treatment with Antimalarials Adversely Affects the Oxidative Energy Metabolism in Rat Liver Mitochondria

Drug and Chemical Toxicology

Volumn 27, Issue 1, 2004, Pages 41-53

  Katewa, Subhash D ^a,b   Katyare, Surendra S ^a  

^a M S UNIVERSITY OF BARODA   (India)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antimalarials; ATPase; Cytochromes; Energy metabolism; Oxidative phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIMALARIAL AGENT; ASCORBIC ACID; CHLOROQUINE; CYTOCHROME B; CYTOCHROME C OXIDASE; GLUTAMIC ACID; MAGNESIUM ION; MALIC ACID; PRIMAQUINE; PYRUVIC ACID; QUININE; SUCCINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; LIVER METABOLISM; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PHOSPHORYLATION; RAT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIMALARIALS; CHLOROQUINE; CYTOCHROMES; ENERGY METABOLISM; MALE; MITOCHONDRIA, LIVER; OXIDATIVE PHOSPHORYLATION; PRIMAQUINE; QUININE; RATS; RATS, INBRED STRAINS;

ANIMALIA; CINCHONA PUBESCENS;

EID: 1542305724     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-120027898     Document Type: Article

References (25)

1. Leslie, T.W., Jr. Drugs used in the chemotherapy of protozoal infections-malaria. In The Pharmacological Basis of Therapeutics, 8th Ed.; Gilmann, A.G., Rall, T.W., Nies, A.S., Taylor, P., Eds.; Pergamon Press: New York, 1990; 959-997.
2. Thabrew, M.I.; Nashiru, T.O.; Emerole, G.O. Drug induced alterations in some rat hepatic microsomal components: a comparative study of four structurally different antimalarials. Comp. Biochem. Physiol., C 1985, 81 (1), 133-138.
3. De Duve, C.; De Barsy, T.; Poole, B.; Trouet, A.; Tulkens, P.; Van Hoof, F. Lysosomotropic agents. Biochem. Pharmacol. 1974, 23, 2495-2568.
4. Foley, M.; Tilley, L. Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents. Pharmacol. Ther. 1998, 79 (1), 55-87.
5. Essien, E.E.; Ette, E.I. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J. Pharm. Pharmacol. 1986, 38 (7), 543-546.
6. Ayitey-Smith, E.; Gbewonyo, A.J. Ultrastructural changes in the heart of rats treated with chloroquine. West Afr. J. Pharmacol. Drug Res. 1977, 4 (1), 7-15.
7. Krungkrai, J.; Burat, D.; Kudan, S.; Krungkrai, S.; Prapunwattana, P. Mitochondrial oxygen consumption in asexual and sexual blood stages of the human malarial parasite, Plasmodium falciparum. Southeast Asian J. Trop. Med. Public Health 1999, 30 (4), 636-642.
8. Lanners, H.N. Effect of the 8-aminoquinoline and primaquine on culture-derived gametocytes of the malaria parasite Plasmodium falciparum. Parasitol. Res. 1991, 77 (6), 478-481.
9. Hostetler, K.Y.; Reasor, M.; Yazaki, P.J. Chloroquine-induced phospholipid fatty liver. Measurement of drug and lipid concentrations in rat liver lysosomes. J. Biol. Chem. 1985, 260 (1), 215-219.
10. Swegert, C.V.; Dave, K.R.; Katyare, S.S. Effect of aluminium-induced alzheimer like condition on oxidative energy metabolism in rat liver, brain and heart mitochondria. Mech. Ageing Dev. 1999, 12, 27-42.
11. Satav, J.G.; Katyare, S.S. Effect of experimental thyrotoxicosis on oxidative phosphorylation in rat liver, kidney and brain mitochondria. Mol. Cell. Endocrinol. 1982, 28, 173-189.
12. Katyare, S.S.; Joshi, M.V.; Fatterpaker, P.; Sreenivasan, A. Effect of thyroid deficiency on oxidative phosphorylation in rat liver, kidney and brain mitochondria. Arch. Biochem. Biophys. 1977, 182, 155-163.
13. Fiske, C.H.; Subba Row, Y. Colorimetric determination of phosphorous. J. Biol. Chem. 1925, 66, 375-381.
14. Poyton, R.O.; Mc Ewen, J.E. Crosstalk between nuclear and mitochondrial genomes. Annu. Rev. Biochem. 1996, 65, 563-607.
15. Katyare, S.S.; Rajan, R.R. Enhanced oxidative phosphorylation in rat liver mitochondria following prolonged in vivo treatment with imipramine. Br. J. Pharmacol. 1988, 95, 914-922.
16. Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; Randall, R.J. Protein measurement with folin-phenol reagent. J. Biol. Chem. 1951, 193, 265-272.
17. Lehninger, A.L. Biochemistry, 1st Ed.; Worth Publishers: New York, 1970; 520.
18. Deepalakshmi, P.D.; Parasakthy, K.; Shanti, S.; Devrajan, N.S. Effect of chloroquine on rat liver mitochondria. Indian J. Exp. Biol. 1994, 32, 797-802.
19. Jarzyna, R.; Lenarcik, E.; Bryla, J. Chloroquine is a potent inhibitor of glutamate dehydrogenase in liver and kidney-cortex of rabbit. Pharmacol. Res. 1997, 35 (1), 79-84.
20. Zubay, J. Biochemistry, 3rd Ed.; WmC Brown Publishers: Dubuque, IA, 1993.
21. Zhao, X.-J.; Ishizaki, T. The in vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes. J. Pharmacol. Exp. Ther. 1997, 283, 1168-1176.
22. Ni, Y.C.; Xu, Y.Q.; Wang, M.J. Rat liver microsomal and mitochondrial metabolism of primaquine in vitro. Zhongguo Yaoli Xuebao 1992, 13 (5), 431-435.
23. Constantino, L.; Paixao, P.; Moreira, R.; Portela, M.J.; Do Rosario, V.E.; Iley, J. Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine. Exp. Toxicol. Pathol. 1999, 51 (4-5), 299-303.
24. Brown, C.G. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 1992, 284, 1-13.
25. Daum, G. Lipids of mitochondria. Biochim. Biophys. Acta 1985, 822, 1-42.