A Pathogenesis-associated Mutation in Human Mitochondrial tRNA Leu(UUR) Leads to Reduced 3′-End Processing and CCA Addition

Journal of Molecular Biology

Volumn 337, Issue 3, 2004, Pages 535-544

  Levinger, Louis ^a,b   Oestreich, Isabel ^c   Florentz, Catherine ^b   Mörl, Mario ^c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b INST DE BIOL MOLEC ET CELLULAIRE   (France)

^c MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY   (Germany)

Author keywords

3 end processing; 3 tRNase; CCA addition; MELAS, mitochondrial encephalomyopathy with lactic acidosis and stroke like episodes; Mitochondrial diseases; tRNA nucleotidyltransferase; Wt, wild type

Indexed keywords

MITOCHONDRIAL RNA; TRANSFER RNA;

AMINO ACID SUBSTITUTION; ARTICLE; DISEASE ASSOCIATION; HUMAN; MELAS SYNDROME; MERRF SYNDROME; MUTATIONAL ANALYSIS; NONHUMAN; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RNA ANALYSIS;

EID: 1542298923     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.02.008     Document Type: Article

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