Study on Ceramide Expression and DNA Content in Patients with Healthy Mucosa, Leukoplakia, and Carcinoma of the Larynx

Archives of Otolaryngology - Head and Neck Surgery

Volumn 130, Issue 3, 2004, Pages 307-310

  Chi, Fang Lu ^a   Yuan, Ya Sheng ^a   Wang, Shu Yi ^a   Wang, Zheng Min ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DNA; SPHINGOMYELIN;

ANEUPLOIDY; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIPLOIDY; DNA DETERMINATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; LARYNX MUCOSA; LEUKOPLAKIA; REVIEW; SECOND MESSENGER;

ANEUPLOIDY; APOPTOSIS; CERAMIDES; DIPLOIDY; DNA, NEOPLASM; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL DISEASES; LARYNGEAL MUCOSA; LARYNGEAL NEOPLASMS; LEUKOPLAKIA; RETROSPECTIVE STUDIES; SECOND MESSENGER SYSTEMS;

EID: 1542288027     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.130.3.307     Document Type: Review

References (17)

1. Searle J, Collins DJ, Harmon B, Kerr JF. The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix. Pathology 1973;5:163-169.
2. Wyllic AH. The biology of cell death in tumours. Anticancer Res. 1985;5:131-136.
3. Mehta S, Blackinton D, Omar I, et al. Combined cytotoxic action of paclitaxel and ceramide against the human Tu 138 head and neck squamous carcinoma cell line. Cancer Chemother Pharmacol. 2000;46:85-92.
4. Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-κB, a member of the TNFR superfamily. J Biol Chem. 1998;273:34120-34127.
5. Di Nardo A, Benassi L, Magnoni C, Cossarizza A, Seidenari S, Giannetti A. Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. Br J Dermatol. 2000;143:491-497.
6. Liu YY, Han TY, Giuliano AE, et al. Glycosylation of ceramide potentates cellular resistance to tumor necrosis factor-α-induced apoptosis. Exp Cell Res. 1999;252:464-470.
7. Sautin Y, Takamura N, Shklyaev S, et al. Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. Thyroid. 2000;10:733-740.
8. Deshmukh GD, Radin NS, Gattone VH, et al. Abnormalities of glycosphingolipid, sulfatide, and ceramide in the polycystic (cpk/cpk) mouse. J Lipid Res. 1994;35:1611-1618.
9. Watanabe M, Kuwano H, Tanaka S, et al. Flow cytometric DNA analysis is useful in detecting multiple genetic alterations in squamous cell carcinoma of the esophagus. Cancer 1999;85:2322-2328.
10. Schackney SE, Berg G, Simon SR, et al. Origins and clinical implications of aneuploidy in early bladder cancer. Cytometry. 1965;22:307-316.
11. Vindelov LL, Christensen IJ, Nissen NI. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry. 1983;3:323-327.
12. Tsutsui S, Ohno S, Murakami S, Hachitanda Y, Oda S. Prognostic value of DNA ploidy in 653 Japanese women with node-negative breast cancer. Int J Clin Oncol. 2001;6:177-182.
13. Tsutsui S, Kuwano H, Mori M, et al. A flow cytometric analysis of DNA content in primary and metastatic lesions of esophageal squamous cell carcinoma. Cancer. 1992;70:2586-2591.
14. Green DR, Martin SJ. The killer and the executioner: how apoptosis controls malignancy. Curr Opin Immunol. 1995;7:694-703.
15. Burow ME, Weldon CB, Tang Y, et al. Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer variants. Cancer Res. 1998;58:4940-4946.
16. Radin NS, Killing cancer cells by poly-drug elevation of ceramide levels a hypothesis whose time has come? Eur J Biochem. 2001;268:193-204.
17. Senchenkov A, Litvak DA, Cabot MC. Targeting ceramide metabolism-a strategy for overcoming drug resistance. J Natl Cancer Inst. 2001;93:347-357.