Measuring the In Vivo Binding Parameters of [18F]-Fallypride in Monkeys Using a PET Multiple-Injection Protocol

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 3, 2004, Pages 309-322

  Christian, Bradley T ^a,d   Narayanan, Tanjore ^a   Shi, Bing ^a   Morris, Evan D ^b   Mantil, Joseph ^a   Mukherjee, Jogeshwar ^c  

^a KETTERING MEDICAL CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WRIGHT STATE UNIVERSITY   (United States)

Author keywords

D2 receptor; Fallypride; Multiple injection PET; Neuroreceptor model

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; FALLYPRIDE F 18; FALLYPRIDE F 19; FLUORINE 18; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CEREBELLUM; CLINICAL PROTOCOL; CORPUS STRIATUM; DRUG BINDING; DRUG RECEPTOR BINDING; FRONTAL CORTEX; MALE; MEASUREMENT; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RECEPTOR DENSITY; RHESUS MONKEY; TEMPORAL CORTEX; THALAMUS;

EID: 1542286816     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000105020.93708.DD     Document Type: Article

References (40)

1. Akaike H (1974) A new look at statistical model identification. IEEE Trans on Auto Control 19:716-723
2. Boellaard R, Van Lingen A, Lammertsma AA (2001) Experimental and clinical evaluation of iterative reconstruction (OSEM) in dynamic PET: Quantitative characteristics and effects on kinetic modeling. J Nucl Med 42:808-817
3. Brix G, Zaers J, Adam LE, Bellemann ME, Ostertag H, Trojan H, Haberkorn U, Doll J, Oberdorfer F, Lorenz WJ (1997) Performance evaluation of a whole-body PET scanner using the NEMA protocol. J Nucl Med 38:1614-1623
4. Christian BT, Narayanan TK, Shi B, Mukherjee J (2000) Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [F-18]fallypride in nonhuman primates. Synapse 38:71-79
5. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AKP (1991) Compartmental analysis of diprenorphine binding to opiate receptors in the rat in vivo and its comparison with equilibrium data in vitro. J Cereb Blood Flow Metab 11:1-9
6. Delforge J, Syrota A, Mazoyer BM (1990) Identifiability analysis and parameter-identification of an in vivo ligand-receptor model from PET data. IEEE Trans Biomed Eng 37:653-661
7. Delforge J, Loch C, Hantraye P, Stulzaft O, Khalilivarasteh M, Maziere M, Syrota A, Maziere B (1991) Kinetic-analysis of central Br-76 bromolisuride binding to dopamine D2 receptors studied by PET. J Cereb Blood Flow Metab 11:914-925
8. Delforge J, Leguludec D, Syrota A, Bendriem B, Crouzel C, Slama M, Merlet P (1993) Quantification of myocardial muscarinic receptors with PET in humans. J Nucl Med 34:981-991
9. Delforge J, Pappata S, Millet P, Samson Y, Bendriem B, Jobert A, Crouzel C, Syrota A (1995) Quantification of benzodiazepine receptors in human brain using PET, C-11 flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 15:284-300
10. Delforge J, Syrota A, Bendriem B (1996) Concept of reaction volume in the in vivo ligand-receptor model. J Nucl Med 37:118-125
11. Delforge J, Bottlaender M, Loch C, Guenther I, Fuseau C, Bendriem B, Syrota A, Maziere B (1999) Quantitation of extrastriatal D2 receptors using a very high-affinity ligand (FLB 457) and the multi-injection approach. J Cereb Blood Flow Metab 19:533-546
12. Delforge J, Bottlaender M, Pappata S, Loch C, Syrota A (2001) Absolute quantification by positron emission tomography of the endogenous ligand. J Cereb Blood Flow Metab 21:613-630
13. DiStefano 3rd JJ (1979) Matching the model and the experiment to the goals: Data limitations, complexity and optimal experiment design for dynamic systems with biochemical signals. J Cybernetic Inform Sci 2:6-20
14. Farde L, Suhara T, Nyberg S, Karlsson P, Nakashima Y, Hietala J, Halldin C (1997) A PET study of C-11 FLB 457 binding to extrastriatal D-2 dopamine receptors in healthy subjects and antipsychotic drug-treated patients. Psychopharmacology 133:396-404
15. Fowler JS, Volkow ND, Logan J, Gatley SJ, Pappas N, King P, Ding YS, Wang GJ (1998) Measuring dopamine transporter occupancy by cocaine in vivo: Radiotracer considerations. Synapse 28:111-116
16. Hall H, Wedel I, Sallemark M (1988) Effects of temperature on the in vitro binding of H-3 raclopride to rat striatal dopamine-D2 receptors. Pharmacol Toxicol 63:118-121
17. Halldin C, Farde L, Hogberg T, Mohell N, Hall H, Suhara T, Karlsson P, Nakashima Y, Swahn CG (1995) Carbon-11-FLB-457 - a radioligand for extrastriatal D2 dopamine-receptors. J Nucl Med 36:1275-1281
18. Ichise M, Toyama H, Innis RB, Carson RE (2002) Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J Cereb Blood Flow Metab 22:1271-1281
19. Kessler RM, Votaw JR, Schmidt DE, Ansari MS, Holdeman KP, Depaulis T, Clanton JA, Pfeffer R, Manning RG, Ebert MH (1993a) High-affinity dopamine D2 receptor radioligands 3. 1-123 and 1-125 epidepride - in vivo studies in rhesus-monkey brain and comparison with in vitro pharmacokinetics in rat-brain. Life Sci 53:241-250
20. Kessler RM, Whetsell WO, Ansari MS, Votaw JR, Depaulis T, Clanton JA, Schmidt DE, Mason NS, Manning RG (1993b) Identification of extrastriatal dopamine D2 receptors in postmortem human brain with 1-125 epidepride. Brain Res 609:237-243
21. Loch C, Halldin C, Bottlaender M, Swahn CG, Moresco RM, Maziere M, Farde L, Maziere B (1996) Preparation of Br-76 FLB 457 and Br-76 FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET. Nucl Med Biol 23:813-819
22. Logan J, Volkow ND, Fowler JS, Wang GJ, Dewey SL, Macgregor R, Schlyer D, Gatley SJ, Pappas N, King P, Hitzemann R, Vitkun S (1994) Effects of blood-flow on C-11 raclopride binding in the brain - model simulations and kinetic-analysis of PET data. J Cereb Blood Flow Metab 14:995-1010
23. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL (1996) Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 16:834-840
24. Mazoyer BM, Huesman RH, Budinger TF, Knittel BL (1986) Dynamic PET data-analysis. J Comput Assist Tomogr 10:645-653
25. Melchitzky DS, Lewis DA (2000) Dopaminergic innervation of the primate mediodorsal thalamic nucleus. Biol Psychiatry 47:480
26. Millet P, Delforge J, Mauguiere F, Pappata S, Cinotti L, Frouin V, Samson Y, Bendriem B, Syrota A (1995) Parameter and index images of benzodiazepine receptor concentration in the brain. J Nucl Med 36:1462-1471
27. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ (1984) A quantitative model for the in vivo assessment of drug-binding sites with positron emission tomography. Ann Neurol 15:217-227
28. Morris ED, Babich JW, Alpert NM, Bonab AA, Livni E, Weise S, Hsu HB, Christian BT, Madras BK, Fischman AJ (1996) Quantification of dopamine transporter density in monkeys by dynamic PET imaging of multiple injections of C-11-CFT. Synapse 24:262-272
29. max? Synapse 32:136-140
30. Mukherjee J, Yang ZY, Das MK, Brown T (1995) Fluorinated benzamide neuroleptics 3. Development of (s)-n-(1-allyl-2-pyrrolidinyl)methyl-5-(3-f-18 fluoropropyl)-2,3-dimethoxy-benzamide as an improved dopamine D-2 receptor tracer. Nucl Med Biol 22:283-296
31. Mukherjee J, Yang ZY, Brown T, Lew R, Wernick M, Ouyang XH, Yasillo N, Chen CT, Mintzer R, Cooper M (1999) Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, F-18-fallypride. Nucl Med Biol 26:519-527
32. Mukherjee J, Christian BT, Narayanan TK, Shi B, Mantil J (2001) Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using F-18-fallypride. Neuropsychopharmacology 25:476-488
33. 18F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors. Synapse 46:170-188
34. Muzic RF, Nelson AD, Saidel GM, Miraldi F (1996) Optimal experiment design for PET quantification of receptor concentration. IEEE Trans Med Imaging 15:2-12
35. Muzic RF, Saidel GM, Zhu N, Nelson AD, Zheng L, Berridge MS (2000) Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration. Med Biol Eng Comput 38:593-602
36. Muzic RF, Cornelius S (2001) COMKAT: Compartment model kinetic analysis tool. J Nucl Med 42:636-645
37. Pilowsky LS, Mulligan RS, Acton PD, Eli PJ, Kerwin RW (1997) Limbic selectivity of clozapine (letter). The Lancet 350:490-491
38. Shi B, Narayanan T, Mattmuller S, Carone M, Christian BT, Mukherjee J, Mantil J (2002) Automated clinical production of fluorine-18 radiopharmaceuticals with electrophilic or nucleophilic substitution in a custom manufactured fluorination module. J Nucl Med 43:5S
39. Slifstein M, Laruelle M (2000) Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med 41:2083-2088
40. Thompson C, Kecani S, Boelen S (2001) Evaluation of a neck-shield for use during neurological studies with a whole-body PET scanner. IEEE Trans Nucl Sci 48:1512-1517