Treatment of Pulmonary Arterial Hypertension with Sildenafil

Hospital Pharmacy

Volumn 39, Issue 3, 2004, Pages 243-253

  Fung, Stacey M ^a   Ferrill, Mary J ^b  

^a GENENTECH INC   (United States)

^b WINGATE UNIVERSITY   (United States)

Author keywords

Primary pulmonary hypertension; Pulmonary arterial hypertension; Pulmonary hypertension; Sildenafil

Indexed keywords

ADENOSINE; ANTICOAGULANT AGENT; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DIURETIC AGENT; ENDOTHELIN RECEPTOR ANTAGONIST; ILOPROST; NIFEDIPINE; NITRIC OXIDE; OXYGEN; PROSTACYCLIN; SILDENAFIL; UNIPROST; VASODILATOR AGENT; WARFARIN;

ABDOMINAL DISCOMFORT; ALGORITHM; ANGINA PECTORIS; BRAIN HEMORRHAGE; CARDIOMYOPATHY; CLINICAL TRIAL; COCHRANE LIBRARY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; COUGHING; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; DYSPEPSIA; EMBASE; FETUS DISEASE; FLUSHING; HEADACHE; HEART DEATH; HEART FAILURE; HEART PALPITATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERTENSION; HYPOTENSION; INJECTION PAIN; LIVER INJURY; LONG TERM CARE; MEDLINE; META ANALYSIS; MONOTHERAPY; NAUSEA; OCCLUSIVE CEREBROVASCULAR DISEASE; OPEN STUDY; OXYGEN THERAPY; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; REVIEW; SHORT COURSE THERAPY; SIDE EFFECT; SYSTEMIC VASCULAR RESISTANCE; THROMBOEMBOLISM; THROMBOSIS;

EID: 1542268243     PISSN: 00185787     EISSN: None     Source Type: Journal    
DOI: 10.1177/001857870403900310     Document Type: Review

References (33)

1. Klings ES, Farber HW, Current management of PPH. Drugs. 2001;61:1945-56.
2. Rubin LJ. Primary pulmonary hypertension. N Engl J Med. 1997;336:111-7.
3. Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet. 2003;361:1533-44.
4. Wilkens H, Guth A, König J, et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation. 2001;104:1218-22.
5. Michelakis E, Tymchak W, Lien D, et al. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension. Comparison with inhaled nitric oxide. Circulation. 2002;105:2398-403.
6. Ghofrani HA, Wiedermann R, Rose F, et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med. 2002;136:515-22.
7. Kothari SS, Duggal B. Chronic oral sildenafil therapy in severe pulmonary artery hypertension. Indian Heart J. 2002;54:404-9.
8. Mehata S. Sildenafil for pulmonary arterial hypertension. Exciting but protection required. Chest. 2003;123:989-92.
9. Ghofrani HA, Rose F, Schermuly RT, et al. Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension. J Am Coll Cardiol. 2003;42:158-64.
10. Viagra (sildenafil citrate) [package insert]. New York, NY: Pfizer Labs; January 2000.
11. Zhao L, Mason NA, Morrell NW, et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. - Circulation. 2001;104:424-8.
12. Weimann J, Ullrich R, Hromi J, et al. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology. 2000;92:1702-12.
13. Ichinose F, Erana-Garcia J, Hromi J, et al. Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med. 2001;29:1000-5.
14. Kleinsasser A, Loeckinger A, Hoermann C, et al. Sildenafil modulates hemodynamics and pulmonary gas exchange. Am J Respir Crit Care Med. 2001;163:339-43.
15. Atz AM, Wessel DL. Sildenafil ameliorates effects of inhaled nitric oxide withdrawal. Anesthesiology. 1999;91:307-10.
16. Mychaskiw G, Sachdev V, Heath BJ. Sildenafil (Viagra) facilitates weaning of inhaled nitric oxide following placement of biventricular-assist device. J Clin Anesth. 2001;13:218-20.
17. Prasad S, Wilkinson J, Gatzoulis MA. Sildenafil in primary pulmonary hypertension. N Engl J Med. 2000;343:1342.
18. Bigatello LM, Hess D, Dennehy KC, et al. Sildenafil can increase the response to inhaled nitric oxide. Anesthesiology. 2000;92:1827-9.
19. Watanabe H, Ohashi K, Takeuchi K, et al. Sildenafil for primary and secondary pulmonary hypertension. Clin Pharmacol Ther. 2002;71:398-402.
20. Abrams D, Schulze-Neick I, Magee AG. Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. Heart. 2000;84:e4.
21. Schumacher YO, Zdebik A, Huonker M, et al. Sildenafil in HIV-related pulmonary hypertension. AIDS. 2001;15:1747-8.
22. Littera R, La Nasa G, Derchi G, et al. Long-term treatment with oral sildenafil in a thalassemic patient with pulmonary hypertension. Blood. 2002;100:1515-6.
23. Stiebellehner L, Petkov V, Vonbank K, et al. Long-term treatment with oral sildenafil in addition to continuous IV epoprostenol in patients with pulmonary arterial hypertension. Chest. 2003;123:1293-1295.
24. Jackson G, Chambers J. Sildenafil for primary pulmonary hypertension: Short and long-term symptomatic benefit. Int J Clin Practice. 2002;56:397-8.
25. Sayin T, Zenci M. Sildenafil in primary pulmonary hypertension: Is there a subset of patients who respond favourably? Can J Cardiol. 2002;18:676-8.
26. Carlson J, Kjeldsen K, Gerstoft J. Sildenafil as a successful treatment of otherwise fatal HIV-related pulmonary hypertension. AIDS. 2002;16:1568-9.
27. Zimmermann AT, Calvert AF, Veitch EM. Sildenafil improves right-ventricular parameters and quality of life in primary pulmonary hypertension. Internal Med J. 2002;32:424-6.
28. Singh B, Gupta R, PUnj V, et al. Sildenafil in the management of primary pulmonary hypertension. Indian Heart J. 2002;54:297-300.
29. Peacock AJ. Treatment of pulmonary hypertension. BMJ. 2003;326;835-6.
30. Lepore JJ, Maroo A, Pereira NL, et al. Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol. 2002;90:677-80.
31. Ghofrani HA, Wiedemann R, Rose F, et al. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: A randomised controlled trial. Lancet. 2002;360:895-900.
32. Ghofrani HA, Schermuly RT, Rose F, et al. Sildenafil for long-term treatment of non operable chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 2003;167:1139-41.
33. Sastry BKS, Narasimhan C, Reddy NK, et al. A study of clinical efficacy of sildenafil in patients with primary pulmonary hypertension. Indian Heart J. 2002;54:410-414.