The effect of Mdr1 induction on the pharmacokinetics of rhodamine 123 in rats

Basic and Clinical Pharmacology and Toxicology

Volumn 96, Issue 3, 2005, Pages 257-258

  Micuda, Stanislav ^a   Mundlova, Lucie ^a   Mokry, Jaroslav ^a   Osterreicher, Jan ^a   Cermanova, Jolana ^a   Cizkova, Dana ^a   Martinkova, Jirina ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BILE FLOW; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG URINE LEVEL; HEPATOBILIARY SYSTEM; IMMUNOBLOTTING; IMMUNODETECTION; IN VIVO STUDY; INTESTINE; KIDNEY CLEARANCE; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; URINE FLOW RATE; WESTERN BLOTTING;

ANIMALS; DEXAMETHASONE; MALE; METABOLIC CLEARANCE RATE; P-GLYCOPROTEIN; RATS; RATS, WISTAR; RHODAMINE 123;

ANIMALIA;

EID: 15244360297     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2005.pto960322.x     Document Type: Conference Paper

References (2)

1. Marzolini, C., E. Paus, T. Buclin & R. B. Kim: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin. Pharmacol. Therap. 2004, 75, 13-33.
2. Yumoto, R., T. Murakami, M. Sanemasa, R. Nasu, J. Nagai & M. Takano: Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone. Drug Metab. Disp. 2001, 29, 145-151.