Decreased expression of G-protein coupled receptor kinase 2 in cold thyroid nodules

Experimental and Clinical Endocrinology and Diabetes

Volumn 113, Issue 2, 2005, Pages 102-106

  Voigt, C ^a   Holzapfel, H P ^a   Paschke, R ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

GRK; Nodule; Protein expression; Thyroid; TSH receptor

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SCINTISCANNING; THYROID NODULE; ULTRASOUND; WESTERN BLOTTING;

G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GENE EXPRESSION REGULATION; HUMANS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; THYROID NODULE;

EID: 15244348255     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-830538     Document Type: Article

References (34)

1. Belfiore A, Rosa GL, Giuffrida D, Regalbuto C, Lupo L, Fiumara A, Ippolito O. The management of thyroid nodules. J Endocrinol Invest 1995; 18: 155-158
2. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci USA 1998; 95: 328-333
3. Daaka Y, Pitcher JA, Richardson M, Stoffel RH, Robishaw JD, Lefkowitz RJ. Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. Proc Natl Acad Sci USA 1997; 94: 2180-2185
4. Davis BJ. Disc electrophoresis. II. Method and application to human serum proteins. Ann New York Acad Sci 1964; 121: 404-427
5. Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circ Res 2000; 86: 43-50
6. Elorza A, Penela P, Sarnago S, Mayor F Jr. MAPK-dependent degradation of G protein-coupled receptor kinase 2. J Biol Chem 2003; 278: 29164-29173
7. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem 1995; 270: 17953-17961
8. Gros R, Benovic JL, Tan CM, Feldman RD. G protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest 1997; 99: 2087-2093
9. Hara T, Namba H, Takamura N, Yang TT, Nagayama Y, Fukata S, Kuma K, Ishikawa N, Ito K, Yamashita S. Thyrotropin regulates c-Jun N-terminal kinase (JNK) activity through two distinct signal pathways in human thyroid cells. Endocrinology 1999; 140: 1724-1730
10. Hedinger C, Wiliams ED, Sobin LH. Histological Typing of Thyroid Tumors. 2nd ed. Berlin, Heidelberg, New York: Springer, 1988
11. Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED, Koch WJ. Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. Am J Physiol 1998; 275: H1298-H1306
12. Iacovelli L, Franchetti R, Masini M, De Blasi A. GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response. Mol Endocrinol 1996; 10: 1138-1146
13. Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G protein-coupled receptor kinase. Functional specificity among G protein coupled receptor kinases. J Biol Chem 1994; 269: 1125-1130
14. Kohout TA, Lefkowitz RJ. Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol Pharmacol 2003; 63: 9-18
15. Krohn K, Emmrich P, Ott N, Paschke R. Increased thyroid epithelial cell proliferation in toxic thyroid nodules. Thyroid 1999; 9: 241-246
16. Krohn K, Fuhrer D, Holzapfel HP, Paschke R. Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations. J Clin Endocrinol Metab 1998; 83: 130-134
17. Krohn K, Reske A, Ackermann F, Muller A, Paschke R. Ras mutations are rare in solitary cold and toxic thyroid nodules. Clin Endocrinol (Oxf) 2001; 55: 241-248
18. Krohn K, Stricker I, Emmrich P, Paschke R. Cold thyroid nodules show a marked increase of proliferation markers. Thyroid 2003; 13: 569-575
19. Krupnick JG, Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 1998; 38: 289-319
20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685
21. Lombardi MS, Kavelaars A, Schedlowski M, Bijlsma JW, Okihara KL, Van de Pol M, Ochsmann S, Pawlak C, Schmidt RE, Heijnen CJ. Decreased expression and activity of G protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J 1999; 13: 715-725
22. Metaye T, Menet E, Guilhot J, Kraimps JL. Expression and activity of G protein-coupled receptor kinases in differentiated thyroid carcinoma. J Clin Endocrinol Metab 2002; 87: 3279-3286
23. Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M. Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor. J Biol Chem 1996a; 271: 10143-10148
24. Nagayama Y, Tanaka K, Namba H, Yamashita S, Niwa M. Expression and regulation of G protein-coupled receptor kinase 5 and beta-arrestin-1 in rat thyroid FRTL5 cells. Thyroid 1996 b; 6: 627-631
25. Penela P, Elorza A, Sarnago S, Mayor FJ. Beta-arrestin- and c-Src-dependent degradation of G protein-coupled receptor kinase 2. EMBO J 2001; 20: 5129-5138
26. Penela P, Ruiz-Gomez A, Castano JG, Mayor F Jr. Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. J Biol Chem 1998; 273: 35238-35244
27. Peppel K, Boekhoff I, McDonald P, Breer H, Caron MG, Lefkowitz RJ. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J Biol Chem 1997; 272: 25425-25428
28. Poertl S, Kirner J, Saller B, Mann K, Hoermann R. T3-release from autonomously functioning thyroid nodules in vitro. Exp Clin Endocrinol Diabetes 1998; 106: 489-493
29. Shklyaev SS, Namba H, Mitsutake N, Alipov G, Nagayama Y, Maeda S, Ohtsuru A, Tsubouchi H, Yamashita S. Transient activation of c-Jun NH2-terminal kinase by growth factors influences survival but not apoptosis of human thyrocytes. Thyroid 2001; 11: 629-636
30. Tiruppathi C, Yan W, Sandoval R, Naqvi T, Pronin AN, Benovic JL, Malik AB. G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Proc Natl Acad Sci USA 2000; 97: 7440-7445
31. Voigt C, Holzapfel H, Paschke R. Expression of beta-arrestins in toxic and cold thyroid nodules. FEBS Lett 2000; 486: 208-212
32. Voigt C, Holzapfel HP, Meyer S, Paschke R. Increased expression of G-protein coupled receptor kinases 3 and 4 in hyperfunctioning thyroid nodules. J Endocrinol 2004; 182: 173-182
33. Wynford-Thomas D, Stringer BM, Harach HR, Williams ED. Control of growth in the rat thyroid - an example of specific desensitization to trophic hormone stimulation. Experientia 1983; 39: 421-423
34. Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet 1997; 15: 175-178