ATP inhibits the hypoxia response in type I cells of rat carotid bodies

Journal of Neurochemistry

Volumn 92, Issue 6, 2005, Pages 1419-1430

  Xu, Jianhua ^a,b   Xu, Fenglian ^a   Tse, Frederick W ^a   Tse, Amy ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Autofeedback regulation; Carotid body; Oxygen sensing; P2y purinoreceptor

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; OXYGEN; PURINE P2Y1 RECEPTOR; SODIUM CHANNEL; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CAROTID BODY; CELL FUNCTION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; HYPERPOLARIZATION; HYPOXIA; IMAGING SYSTEM; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SODIUM CELL LEVEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CAROTID BODY; FEEDBACK, BIOCHEMICAL; HOMEOSTASIS; MALE; MEMBRANE POTENTIALS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; REFLEX; SODIUM CHANNELS;

EID: 15244346901     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02978.x     Document Type: Article

References (35)

1. 2+ currents by dopamine in glomus cells of the carotid body. Eur. J. Neurosci. 2, 809-812.
2. Bright G. R., Agani F. H., Haque U., Overholt J. L. and Prabhakar N. R. (1996) Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells. Brain Res. 706, 297-302.
3. Buckler K. J. (1997) A novel oxygen-sensitive potassium current in rat carotid body type I cells. J. Physiol. 498, 649-662.
4. Buckler K. J. and Vaughan-Jones R. D. (1994a) Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J. Physiol. 476, 423-428.
5. Buckler K. J. and Vaughan-Jones R. D. (1994b) Effects of hypercapnia on membrane potential and intracellular calcium in rat carotid body type I cells. J. Physiol. 478, 157-171.
6. Buckler K. J., Williams B. A. and Honore E. (2000) An oxygen-, acid-and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J. Physiol. 525, 135-142.
7. Buttigieg J. and Nurse C. A. (2004) Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body. Biochem. Biophy. Res. Comm. 322, 82-87.
8. + conductance in rat carotid body type I cells. Neuroreport 12, 1421-1425.
9. 2+ channel currents in bovine adrenal chromaffin cells. Neuron 16, 1027-1036.
10. Di Virgilio F., Chiozzi P., Ferrari D., Falzoni S., SanZ. J. M., Morelli A., Torboli M., Bolognesi F. and Baricordi R. (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97, 587-600.
11. Donnelly D. F. and Kholwadwala D. (1992) Hypoxia decreases intracellular calcium in adult rat carotid body glomus cells. J. Neurophysiol. 67, 1543-1551.
12. A receptors and TASK-1. J. Physiol. 553, 83-94.
13. Fitzgerald R. S. (2000) Oxygen and carotid body chemotransduction: the cholinergic hypothesis - a brief history and new evaluation. Respir. Physiol. 120, 89-104.
14. Gonalez C., Almaraz L., Obeso A. and Rigual R. (1994) Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol. Rev. 74, 829-897.
15. Grönblad M. (1983) Function and structure of the carotid body. Med. Biol. 61, 229-248.
16. GrynkiewicZ. G., Poenie M. and Tsien R. Y. (1985) A new generation of Ca indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
17. López-Barneo J. (1996) Oxygen-sensing by ion channels and the regulation of cellular functions. Trends Neuroscience 19, 43-440.
18. + current in chemoreceptor cells of rabbit carotid body. J. Physiol. 460, 15-32.
19. López-LópeZ. J. R., Gonzale C. and Pérez- García M. T. (1997) Properties of ionic currents from isolated adult rat carotid body chemoreceptor cells: effect of hypoxia. J. Physiol. 499, 429-441.
20. Marino F., Cosentino M., Bombelli R., Ferrari M., Lecchini S. and Frigo G. (1999) Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells. Exp. Hematol. 27, 489-495.
21. McDonald D. M. (1981) Peripheral chemoreceptors: structure-function relationships of the carotid body, in Regulation of Breathing (Hornbein, T. F., ed.), pp. 105-319. Dellker, New York.
22. c increase without corresponding increases in CNS activity. Resp. Physiol. Neurobiol. 138, 1-18.
23. 1 receptors and TPα receptors in platelets showed a major pool associated with membranes of α-granules and the open canalicular system. Blood 101, 1400-1408.
24. Pardal R., Ludewig U., García-Hirschfeld J. and López-Barneo J. (2000) Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium. Proc. Natl. Acad. Sci. USA 91, 2361-2366.
25. + current. Neurosci. Lett. 119, 253-256.
26. + channels in rat carotid body type I cells by protein kinase C. J. Physiol. 512, 743-750.
27. Prabhakar N. R. (2000) Oxygen sensing by the carotid body chemoreceptors. J. Appl. Physiol. 88, 2287-2295.
28. Prasad M., Fearon I. M., Zhang M., Laing M., Vollmer C. and Nurse C. A. (2001) Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J. Physiol. 537, 667-677.
29. Ralevic V. and Burnstock G. (1998) Receptors for purines and pyrimidines. Pharmacol. Rev. 50, 415-492.
30. Reguzzoni M., Cosentino M., Rasini E., Marino F., Ferrari M., Bombelli R., Congiu T., Protasoni M., Quacci D., Lecchini S., Raspanti M. and Frigo G. (2002) Ultrastructural localization of tyrosine hydroxylase in human peripheral blood mononuclear cells: effect of stimulation with phytohaemagglutinin. Cell Tissue Res. 310, 297-304.
31. + channels of rat chemoreceptor cells by a membrane restricted and CO-sensitive mechanism. Circ Res. 89, 430-436.
32. 2+ oscillations and exocytosis in identified rat corticotrophs. J. Physiol. 512, 385-393.
33. 2+ entry and quantal dopamine secretion in carotid body glomus cells. Proc. Natl. Acad. Sci. USA 91, 10 208-10 211.
34. 2+ release in type II cells of the rat carotid body. J. Physiol. 549, 739-747.
35. Zhang M, Zhong H., Vollmer C. and Nurse C. A. (2000) Co-release of ATP and ACh mediates hypoxic signaling at rat carotid body chemoreceptors. J. Physiol. 525, 143-158.