The necessary parameters for estimating the time-course of receptor occupancy [5]

International Journal of Neuropsychopharmacology

Volumn 8, Issue 1, 2005, Pages 143-144

  Takano, Akihiro ^a   Suhara, Tetsuya ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT; OLANZAPINE; RISPERIDONE;

DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG RECEPTOR BINDING; LETTER; MATHEMATICAL ANALYSIS; PARAMETER; PHARMACODYNAMICS; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RECEPTOR OCCUPANCY; SIMULATION; TIME;

ANTIPSYCHOTIC AGENTS; BRAIN; HALF-LIFE; HUMANS; METABOLIC CLEARANCE RATE; MODELS, STATISTICAL; RECEPTORS, DOPAMINE D2; REPRODUCIBILITY OF RESULTS;

EID: 15244345836     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145704004961     Document Type: Letter

References (4)

1. Olsson H, Farde L (2005). Half-life of receptor occupancy - a meaningless concept. International Journal of Neuropsychopharmacology 8, 141-142. DOI: 10.1017/S1461145704004766.
2. 2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics. International Journal of Neuropsychopharmacology 7, 19-26.
3. Tauscher J, Jones C, Remington G, Zipursky RB, Kapur S (2002). Significant dissociation of brain and plasma kinetics with antipsychotics. Molecular Psychiatry 7, 317-321.
4. Tort A, Souza D, Lara D (2005). On the simulation of the time-course of dopamine D2 receptor occupancy from the pharmacokinetics of antipsychotics. International Journal of Neuropsychopharmacology 8, 137-139. DOI: 10.1017/S1461145704004778.