Rhinosporidiosis: What is the cause?

Current Opinion in Infectious Diseases

Volumn 18, Issue 2, 2005, Pages 113-118

  Arseculeratne, Sarath Nanda ^a  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

Biocide and drug sensitivity; Genetic heterogeneity; Immune evasion; Mesomycetozoea; R. Seeberi; Viability of endospores

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIINFECTIVE AGENT; BIOCIDE; LIPID; PROTEIN;

ANTIBODY SPECIFICITY; CELLULAR IMMUNITY; ELECTRON MICROSCOPY; ENDOMYCETALES; GENETIC HETEROGENEITY; HUMAN; HUMORAL IMMUNITY; MOLECULAR BIOLOGY; MYCOSIS; NONHUMAN; NUCLEIC ACID ANALYSIS; PATHOGENICITY; REVIEW; RHINOSPORIDIUM; SENSITIVITY ANALYSIS;

EID: 15044342033     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.qco.0000160898.82115.e8     Document Type: Review

References (29)

1. Herr RA, Ajello L, Taylor JW, et al. Phylogenetic analysis of Rhinosporidium seeberi's 18S, small-subunit ribosomal DNA groups this pathogen among members of the protoctistan Mesomycetozoa clade. J Clin Microbiol 1999; 37:2750-2754.
2. Mendoza L, Taylor JW, Ajello L. The class Mesomycetozoea: a heterogeneous group of microorganisms at the animal-fungal boundary. Annu Rev Microbiol 2002;55:315-344.
3. Fredricks DN, Jolly JA, Lepp PW, et al. Rhinosporidium seeberi: a human pathogen from a novel group of aquatic protistan parasites. Emerging infect Dis 2000;6:273-282.
4. Ahluwalia KB, Maheshwari N, Deka RC. Rhinosporidiosis: a study that resolves etiologic controversies. Am J Rhinol 1997;11:479-483.
5. Ahluwalia KB. Culture of the organism that causes rhinosporidiosis. J Laryngol Otol 1999;131:523-528.
6. Arseculeratne SN. Microcystis aeruginosa as the causative organism of rhinosporidiosis. Mycopathologia 2000;151:3-4.
7. Mendoza L, Herr RA, Ajello L. Authors' reply Causative agent of rhinosporidiosis. J Clin Microbiol 2001;39:413-415.
8. Arseculeratne SN, Atapattu DN. Recent advances in knowledge on Rhinosporidium seeberi and rhinosporidiosis. In: Kushwaha RKS, editor. Fungi in human and animal health. Jodhpur: Scientific Publishers (India); 2004. pp. 257-295. A detailed, illustrated review of the disease and its pathogen. Sections covered in the present review are discussed in depth.
9. Arseculeratne SN, Atapattu DN, Wickremaratne K. The nature and significance of the electron dense bodies of the endospores of Rhinosporidium seeberi: their reactions with MTT (3-[4,5-dimethyl-2-thiazoiyl]-2,5-diphenyl-2H- tetrazolium bromide) and TMRE (tetramethyl rhodamine ethyl ester). Med Microbiol (in press).
10. Arseculeratne SN, Atapattu DN. The assessment of the viability of the endospores of Rhinosporidium seeberi with MTT (3-[4,5-dimethyl-2-thiazolyl]-2,5 diphenyl-2H-tetrazolium bromide). Mycol Res (in press).
11. Arseculeratne SN, Mendoza L. Rhinosporidium seeberi. In: Hay RJ, Merz WM, editors. Medical mycology. 10th ed, vol. 4. London: Arnold Hodder (in press).
12. Kennedy FA, Buggage RR, Ajello L. Rhinosporidiosis: a description of an unprecedented outbreak in captive swans (Cygnus spp.) and a proposal for revision of the ontogenic nomenclature of Rhinosporidium seeberi. J Med Vet Mycol 1995;37:157-165.
13. Arseculeratne SN. The effect of biocides (antiseptics and disinfectants) on the endospores of Rhinosporidium seeberi. Proc Sri Lanka Coll Microbiol 2002; OP8.
14. Arseculeratne SN, Atapattu DN, Eriyagama NB. The use of the Evan's Blue (EvB) and MTT-staining methods for assessment of sensitivity of the endospores of Rhinosporidium seeberi to anti-microbial drugs and anti-rhinosporidial antibody. Bull Sri Lanka Coll Microbiol 2003; 1:OP11. This report is of preliminary results on drug-sensitivity testing with R. seeberi, using the MTT-reduction method as a test of viability. It is clearly of importance in providing alternative therapies to dapsone, which remains the only drug that is now used, based mainly on clinical evidence.
15. Arseculeratne SN, Atapattu DN, Eriyagama NB. Human anti-rhinosporidial antibody does not cause metabolic inactivation or morphological damage in endospores of Rhinosporidium seeberi, in vitro. Indian J Med Microbiol (in press).
16. Appuhamy S, Atapattu DN, Arseculeratne SN, Eriyagama NB. Strain variation in Rhinosporidium seeberi. Proc Sri Lanka Coll Microbiol 2002; OP7.
17. Herr RA, Mendoza L, Arseculeratne SN, Ajello L. Immunolocalization of an endogenous antigenic material of Rhinosporidium seeberi expressed only during mature sporangial development. FEMS Immunol Med Microbiol 1999; 23:205-212.
18. Atapattu DN, Arseculeratne SN, Rajapakse RPVJ, et al. Is human IgG bound by endospores and sporangia of Rhinosporidium seeberi? A possible mechanism of immune evasion. Proc Kandy Soc Med 2000; 22:34.
19. Chitravel V, Sundararaj T, Subramanian S, et al. Detection of circulating antigen in patients with rhinosporidiosis. Sabouraudia 1982; 20:185-191.
20. Atapattu DN, Arseculeratne SN, Rajapakse RPVJ, et al. Purification of the endospores and sporangia of Rhinosporidium seeberi on Percoli columns. Mycopathologia 1999; 145:113-119.
21. Arseculeratne SN, Hussein FN, Atapattu DN, Pathmanathan R. Failure to infect congenially immunodeficient SCID and NUDE mice with Rhinosporidium seeberi. Med Mycol 2000; 38:393-395.
22. de Silva NR, Huegel Heino, Atapattu DN, et al. Cell-mediated immune responses in human rhinosporidiosis. Mycopathologia 2000; 152:59-68.
23. Arseculeratne SN, Wickremesinghe G, Atapattu DN. Interaction of the endospores of Rhinosporidium seeberi with Hep2 cells: a phenomenon that recalls polar filament extrusion in Microsporidia. Bull Sri Lanka Coll Microbiol 2004; 2:OP15.
24. Vukovic A, Bobic-Radovanovic A, Latkovic Z, et al. An epidemiological investigation of the first outbreak of rhinosporidiosis in Europe. J Trop Med Hyg 1995; 98:333-357.
25. Arseculeratne SN, Panabokke RG, Atapattu DN. Lymphadenitis, trans-epidermal elimination and unusual histopathology in human rhinosporidiosis. Mycopathologia 2001; 153:57-69.
26. Mendoza L, Herr RA, Arseculeratne SN, Ajello L. In vitro studies on the mechanisms of endospore release by Rhinosporidium seeberi. Mycopathologia 2000; 148:9-15.
27. Arseculeratne SM, Kumarasiri PVR, Rajapakse RPVJ, et al. Anti-rhinosporidial antibody levels in patients with rhinosporidiosis and in asymptomatic persons in Sri Lanka. Mycopathologia 2004; 158:157-164. The first report on humoral antirhinosporidial responses in human rhinosporidiosis, which also indicates widespread immune sensitization in populations exposed to the aquatic pathogen that might complicate future studies in sero-epidemiology of rhinosporidiosis.
28. Chitravel V, Sundararaj T, Subramanian S, et al. Cell mediated immune responses in human cases of rhinosporidiosis. Sabouraudia 1981; 19: 135-142.
29. Jayasekera S, Arseculeratne SN, Atapattu DN, et al. Cell-mediated immune responses (CMIR) to Rhinosporidium seeberi in mice. Mycopathologia 2000; 152:69-79.