The K-complex: A 7-decade history

Sleep

Volumn 28, Issue 2, 2005, Pages 255-273

  Colrain, Ian M ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b SRI INTERNATIONAL   (United States)

Author keywords

Autonomic; Delta; History; K complex

Indexed keywords

AROUSAL; CENTROMERE; DELTA RHYTHM; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; HUMAN; INFORMATION PROCESSING; NEUROPHYSIOLOGY; NONHUMAN; OSCILLATION; PHENOMENOLOGY; PRIORITY JOURNAL; REVIEW; SLEEP PARAMETERS; SLOW BRAIN WAVE; STIMULUS RESPONSE; THALAMOCORTICAL TRACT; THEORY; TOPOGRAPHY; WAKEFULNESS;

EID: 14944383467     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/28.2.255     Document Type: Review

References (182)

1. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques, and Scoring Systems for Sleep Stages of Human Subjects Washington: US Government Printing Office; 1968.
2. Conant J. Tuxedo Park: A Wall Street Tycoon and the Secret Palace of Science that Changed the Course of World War II. New York: Simon & Schuster; 2002.
3. Berger H. Über das Elektrenkephalogramm des Menschen. Archiv forschung Psychiatrie 1929;87:527-70.
4. Loomis AL, Harvey EN, Hobart G. Distribution of disturbance patterns in the human electroencephalogram, with special reference to sleep. J Neurophysiol 1938;13(Suppl):231-56.
5. Loomis AL, Harvey EN, Hobart G. Potential rhythms of the cerebral cortex during sleep. Science 1935;81:597-8.
6. Loomis AL, Harvey EN, Hobart G. Further observations on the potential rhythms of the cerebral cortex during sleep. Science 1935;82:198-200.
7. Loomis AL, Harvey EN, Hobart G. Brain potentials during hypnosis. Science 1936;83:239-41.
8. Loomis AL, Harvey EN, Hobart G. Electrical potentials of the human brain. J Exp Psychol 1936;19:249-79.
9. Davis H, Davis PA, Loomis AL, Harvey EN, Hobart G. Changes in human brain potentials during the onset of sleep. Science 1937;86:448-50.
10. Loomis AL, Harvey EN, Hobart G. Cerebral states during sleep as studied by human brain potentials. J Exp Psychol 1937;21:127-44.
11. Loomis AL, Harvey EN, Hobart G. Cerebral processes during sleep as studied by human brain potentials. Science 1937;85:443-4.
12. Davis H, Davis PA, Loomis AL, Harvey EN, Hobart G. Human brain potentials during the onset of sleep. J Neurophysiol 1938;1:24-38.
13. Davis H, Davis PA, Loomis AL, Harvey EN, Hobart G. Electrical reactions of the human brain to auditory stimulation during sleep. J Neurophysiol 1939;2:500-14.
14. Webster KE, Colrain IM. Multichannel EEG analysis of respiratory evoked-potential components during wakefulness and NREM sleep. J Appl Physiol 1998;85:1727-35.
15. Bastien C, Campbell K. Effects of rate of tone-pip stimulation on the evoked K-Complex. J Sleep Res 1994;3:65-72.
16. Crowley K, Trinder J, Colrain IM. Evoked K-complex generation: the impact of sleep spindles and age. Clin Neurophysiol 2004;115:471-6.
17. Dutertre F. Catalogue of the main EEG patterns. In: Remond A, ed. Handbook of Electroencephalography and Clinical Neurophysiology. Vol. 11A. Amsterdam: Elsevier; 1977:40-79.
18. Gora J, Colrain IM, Trinder J. The investigation of K-complex and vertex sharp wave activity in response to mid-inspiratory occlusions and complete obstructions to breathing during NREM sleep. Sleep 2001;24:81-9.
19. Brazier MAB. The electrical fields at the surface of the head during sleep. Electroencephalogr Clin Neurophysiol 1949;1:195-204.
20. Cote KA, de Lugt DR, Langley SD, Campbell KB. Scalp topography of the auditory evoked K-complex in stage 2 and slow wave sleep. J Sleep Res 1999;8:263-72.
21. Colrain IM, Webster KE, Hirst G. The N550 component of the evoked K-complex: a modality non-specific response? J Sleep Res 1999;8:273-80.
22. Niiyama Y, Fushimi M, Sekine A, Hishikawa Y. K-complex evoked in NREM sleep is accompanied by a slow negative potential related to cognitive process. Electroencephalogr Clin Neurophysiol 1995;95:27-33.
23. Grossman C. Sensory stimulation during sleep. Electroencephalogr Clin Neurophysiol 1949;1:487-90.
24. Schwab R-S, Passouant P, Cadilhac J. Action des stimulations auditives rythmees sur le sommeil humain. Montpellier Med. 1954;45:501-14.
25. Roth M, Shaw J, Green J. The form, voltage distribution and physioloogical significance of the K-complex. Electroencephalogr Clin Neurophysiol 1956;8:385-402.
26. Williams HL, Tepas DI, Morlock HC. Evoked responses to clicks and electroencephalographic stages of sleep in man. Science 1962;138:685-6.
27. Walter WG The Living Brain. New York: Norton and Company; 1953.
28. Aserinsky E, Kleitman N. Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science 1953:273-4.
29. Dement W, Kleitman N. Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalogr Clin Neurophysiol 1957:673-90.
30. Ackner B, Pampiglione G. Some relationships between peripheral vasomotor and EEG changes. J Neurol Neurosurg Psychiatry 1957;20:58-64.
31. Pampiglione G, Ackner B. The effects of repeated stimuli upon EEG and vasomotor activity during sleep in man. Brain 1958;81:64-74.
32. Oswald I, Taylor AM, Treisman M. Discriminative responses to stimulation during human sleep. Brain 1960;83:440-52.
33. Beh HC, Barratt PE. Discrimination and conditioning during sleep as indicated by the electroencephalogram. Science 1965;147:1470-1.
34. Vetter K, Boker W. Zur Funktion des K-komplexes im Schlaf- Elektrencephalogramm. Nervenarzt 1962;33:390-4.
35. Silverman D. Retrospective study of the EEG in coma. Electroencephalogr Clin Neurophysiol 1963;15:486-503.
36. Chatrian GE, White LE, Daly D. Electroencephalographic patterns resembling those of sleep in certain comatose states after injury to the head. Electroencephalogr Clin Neurophysiol 1963;15:272-80.
37. Chatrian GE, White LE. Sleep EEG patterns in certain comatose states following brain concussion. Electroencephalogr Clin Neurophysiol 1961;13:661.
38. Evans BM, Bartlett JR. Prediction of outcome in severe head injury based on recognition of sleep related activity in the polygraphic electroencephalogram. J Neurol Neurosurg Psychiatry 1995;59:17-25.
39. Alster J, Pratt H, Feinsod M. Density spectral array, evoked potentials, and temperature rhythms in the evaluation and prognosis of the comatose patient. Brain Inj 1993;7:191-208.
40. Lairy G-C, Cor-Mordret M, Faure R, Ridjanovic S. Etude EEG du sommeil du vieillard normal et pathologique. Rev Neurol 1962;107:188-202.
41. Hess R. The electroencephalogram in sleep. Electroencephalogr Clin Neurophysiol 1964;16:44-55.
42. Hess R. Sleep and sleep disturbances in the electroencephalogram. In: Akert K, Belly C, Schade J, eds. Sleep Mechanisms. Amsterdam: Elsevier; 1965:127-39.
43. Weitzman ED, Kremen H. Auditory evoked responses during different stages of sleep in man. Electroencephalogr Clin Neurophysiol 1965;18:65-70.
44. Goff WR, Allison T, Shapiro A, Rosner BS. Cerebral somatosensory responses evoked during sleep in man. Electroencephalogr Clin Neurophysiol 1966;21:1-9.
45. Williams HL, Hammack JT, Daly RL, Dement WC, Lubin A. Responses to auditory stimulation, sleep loss, and the EEG stages of sleep. Electroencephalogr Clin Neurophysiol 1964;16:269-79.
46. Johnson LC, Lubin A. The orienting reflex during waking and sleeping. Electroencephalogr Clin Neurophysiol 1967;22:11-21.
47. Johnson LC, Karpan WE. Autonomic correlates of the spontaneous K-complex. Psychophysiology 1968;4:444-52.
48. Terzano MG, Mancia D, Salati MR, Costani G, Decembrino A, Parrino L. The cyclic alternating pattern as a physiologic component of normal NREM sleep. Sleep 1985;8:137-45.
49. Sforza E, Jouny C, Ibanez V. Cardiac activation during arousal in humans: further evidence for hierarchy in the arousal response. Clin Neurophysiol 2000;111:1611-9.
50. Sassin JF, Johnson LC. Body motility during sleep and its relation to the K-complex. Exp Neurol 1968;22:133-44.
51. Halasz P. Arousals without awakening-dynamic aspect of sleep. Physiol Behav 1993;54:795-802.
52. Terzano MG, Parrino L, Fioriti G, Orofiamma B, Depoortere H. Modifications of sleep structure induced by increasing levels of acoustic perturbation in normal subjects. Electroencephalogr Clin Neurophysiol 1990;76:29-38.
53. Bremer G, Smith JR, Karacan I. Automatic detection of the K-complex in sleep electroencephalograms. IEEE Trans Biomed Eng 1970;17:314-23.
54. Da Rosa AC, Kemp B, Paiva T, Lopes da Silva FH, Kamphuisen HA. A model-based detector of vertex waves and K complexes in sleep electroencephalogram. Electroencephalogr Clin Neurophysiol 1991;78:71-9.
55. da Rosa AC, Paiva T. Automatic detection of K-complexes: validation in normals and dysthymic patients. Sleep 1993;16:239-48.
56. Bankman IN, Sigillito VG, Wise RA, Smith PL. Feature-based detection of the K-complex wave in the human electroencephalogram using neural networks. IEEE Trans Biomed Eng 1992;39:1305-10.
57. Richard C, Lengelle R. Joint time and time-frequency optimal detection of K-complexes in sleep EEG. Comput Biomed Res 1998;31:209-29.
58. Jansen BH, Desai PR. K-complex detection using multi-layer perceptrons and recurrent networks. Int J Biomed Comput 1994;37:249-57.
59. Jobert M, Poiseau E, Jahnig P, Schulz H, Kubicki S. Pattern recognition by matched filtering: an analysis of sleep spindle and K-complex density under the influence of lormetazepam and zopiclone. Neuropsychobiology 1992;26:100-7.
60. Hughes JR. The development of the vertex sharp transient. Clin Electroencephalogr 1998;29:183-7.
61. Firth H. Habituation during sleep. Psychophysiology 1973;10:43-51.
62. McDonald DG, Schicht WW, Frazier RF, Shallenberger HD, Edwards DJ. Studies of information processing in sleep. Psychophysiology 1975;12:624-9.
63. Church MW, Johnson LC, Seales DM. Evoked K-complexes and cardiovascular responses to spindle-synchronous and spindle-asynchronous stimulus clicks during NREM sleep. Electroencephalogr Clin Neurophysiol 1978;45:443-53.
64. Johnson LC, Hanson K, Bickford RG. Effect of Flurazepam on sleep spindles and K-complexes. Electroencephalogr Clin Neurophysiol 1976;40:67-77.
65. Johnson LC, Seales DM, Naitoh P, Church MW, Sinclair M. The effects of flurazepam hydrochloride on brain electrical activity during sleep. Electroencephalogr Clin Neurophysiol 1979;47:309-21.
66. Yamadori A. Role of the spindles in the onset of sleep. Jobe J Med Sci 1971;17:97-111.
67. Selbach H. The principle of relaxation oscillation as a special instance of the law of initial value in cybernetic functions. Ann N Y Acad Sci 1962;98:1221-8.
68. Halász P, Rajna P, Pál I, Balogh A, Dévényi É. Spontaneous and evoked synchronization reactions in sleep. Act Nerv Sup (Praha) 1977;19:211-2.
69. Halász P, Rajna P, Pal I, et al. Certain electrographic parameters of night sleep as tracers of the dyanmics of the sleep-waking system. Recent Developments of Neurobiology in Hungary VIII. Budapest: Akadémiai Kiadó; 1979:179-209.
70. Halász P. Generalized epilepsy with spike-wave paroxysms as an epileptic disorder of the function of sleep promotion. Acta Physiol Acad Sci Hung 1981;57:51-86.
71. Halász P, Pál I, Rajna P. K-complex formation of the EEG in sleep. A survey and new examinations. Acta Physiol Hung 1985;65:3-35.
72. Ferri R, Parrino L, Smerieri A, et al. Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep. J Sleep Res 2000;9:13-8.
73. Evarts EV. Effects of sleep on photically evoked responses in man. Fed Proc 1961;20:332.
74. Ciganek L. The EEG response (evoked potential) to light stimulus in man. Electroencephalogr Clin Neurophysiol 1961;13:165-72.
75. Tizard B. Evoked changes in EEG and electrodermal activity during the waking and sleeping states. Electroencephalogr Clin Neurophysiol 1966;20:122-8.
76. Takigawa M, Taira N. A correlation between k-complex and auditory evoked potential (ARP) during the slow wave sleep (stage 3) in man. No To Shinkei 1980;32:669-73.
77. Nordby H, Hugdahl K, Stickgold R, Bronnick KS, Hobson JA. Event-related potentials (ERPs) to deviant auditory stimuli during sleep and waking. Neuroreport 1996;7:1082-6.
78. Ogilvie RD, Simons IA, Kuderian RH, MacDonald T, Rustenburg J. Behavioral, event-related potential, and EEG/FFT changes at sleep onset. Psychophysiology 1991;28:54-64.
79. Rajna P, Halasz P, Kundra O, Pal I. Event-related non-specific responses (K-complexes) during sleep. Acta Med Hung 1983;40:33-40.
80. Halász P, Ujszàszi J, Gadoros J. Are microarousals preceded by electroencephalographic slow wave synchronization precursors of confusional awakenings? Sleep 1985;8:231-8.
81. Pal I, Simon G, Halasu P. K-complex formation as a function of the ongoing EEG activity. In: Koella WP, Ruther E, Schulz H, eds. Sleep '84. New York: Raven Press; 1985:232-4.
82. Ujszàszi J, Halász P. Long latency evoked potential components in human slow wave sleep. Electroencephalogr Clin Neurophysiol 1988;69:516-22.
83. Campbell KB, Bell I, Deacon-Elliott D. Stimulus related influences on the evoked K-complex. In: Koella WP, Ruther E, Schulz H, eds. Sleep '84. New York: Raven Press; 1985:235-7.
84. Ujszàszi J, Halász P. Late component variants of single auditory evoked responses during NREM sleep stage 2 in man. Electroencephalogr Clin Neurophysiol 1986;64:260-8.
85. Bastien C, Campbell K. The evoked K-complex: all-or-none phenomenon? Sleep 1992;15:236-45.
86. Campbell K, Rouillard L, Bastien C. Component structure of the evoked K-complex. In: Horne J, ed. Sleep '90. Bochum: Pontenagel Press; 1990:17-9.
87. Harsh J, Voss U, Hull J, Schrepfer S, Badia P. ERP and behavioral changes during the wake/sleep transition. Psychophysiology 1994;31:244-52.
88. Sekine A, Niiyama Y, Fujiwara R, et al. A negative component on event related potential recorded in the drowsy state. Psychiatry Clin Neurosci 1998;52:149-50.
89. Colrain IM, Webster KE, Hirst G, Campbell KB. The roles of vertex sharp waves and K-complexes in the generation of N300 in auditory and respiratory-related evoked potentials during early stage 2 NREM sleep. Sleep 2000;23:97-106.
90. Nicholas CL, Trinder J, Colrain IM. Increased production of evoked and spontaneous K-complexes following a night of fragmented sleep. Sleep 2002;25:882-7.
91. Crowley K, Trinder J, Colrain IM. An examination of evoked K-complex amplitude and frequency of occurrence in the elderly. J Sleep Res 2002;11:129-40.
92. Afifi L, Guilleminault C, Colrain IM. Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS. Respir Physiol Neurobiol 2003;136:221-34.
93. Nicholas CL, Sullivan EV, Pfefferbaum A, Trinder J, Colrain IM. The effects of alcoholism on auditory evoked potentials during sleep. J Sleep Res 2002;11:247-53.
94. Crowley KE, Colrain IM. A review of the evidence for P2 being an independent component process: age, sleep and modality. Clin Neurophysiol 2004;115:732-44.
95. Bastien CH, Crowley KE, Colrain IM. Evoked potential components unique to non-REM sleep: relationship to evoked K-complexes and vertex sharp waves. Int J Psychophysiol 2002;46:257-74.
96. Vanzulli A, Bogacz J, Handler P, Garcia-Austt E. Evoked response in man. I. Photic responses. Acta Neurol Latin Am 1960;6:219-31.
97. Crowley K, Sullivan EV, Colrain IM. K-complex elicitation and amplitude are independent of ISI. Sleep 2003;26:A70.
98. Niiyama Y, Satoh N, Kutsuzawa O, Hishikawa Y. Electrophysiological evidence suggesting that sensory stimuli of unknown origin induce spontaneous K-complexes. Electroencephalogr Clin Neurophysiol 1996;98:394-400.
99. De Gennaro L, Ferrara M, Bertini M. The spontaneous K-complex during stage 2 sleep: is it the 'forerunner' of delta waves? Neurosci Lett 2000;291:41-3.
100. Wauquier A, Aloe L, Declerck A. K-complexes: are they signs of arousal or sleep protective? J Sleep Res 1995;4:138-43.
101. Amzica F, Steriade M. The functional significance of K-complexes. Sleep Med Rev 2002;6:139-49.
102. Nicholas CL, Trinder J, Colrain IM. Evoked K-complex elicitation at transitions from stage 2 to slow wave sleep and stage 2 to REM sleep. Sleep 2003;25:A74.
103. Borbély AA. Processes underlying sleep regulation. Horm Res 1998;49:114-117.
104. Borbély AA. A two-process model of sleep regulation. Hum Neurobiol 1982;1:195-204.
105. Schulz H, Stolz C, Muller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study. Pharmacopsychiatry 1994;27:147-51.
106. Hayashida N, Nakazawa Y, Sakamoto T, et al. Effects of Zopiclone on slow wave sleep and spontaneous K-complexes for normal healthy adults. Jap J Psychiatry 1993;47:893-9.
107. Peszka J, Harsh J. Effect of sleep deprivation on NREM sleep ERPs and related activity at sleep onset. Int J Psychophysiol 2002;46:275-86.
108. Curcio G, Ferrara M, Pellicciari MC, Cristiani R, De Gennaro L. Effect of total sleep deprivation on the landmarks of stage 2 sleep. Clin Neurophysiol 2003;114:2279-85.
109. Crowley K, Trinder J, Kim Y, Carrington M, Colrain IM. The effects of normal aging on sleep spindle and K-complex production. Clin Neurophysiol 2002;113:1615-22.
110. Kubicki S, Scheuler W, Jobert M, Pastelak-Price C. The effect of age on sleep spindle and K complex density. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb 1989;20:59-63.
111. Wauquier A. Aging and changes in phasic events during sleep. Physiol Behav 1993;54:803-6.
112. Karadeniz D, Ondze B, Besset A, Billiard M. EEG arousals and awakenings in relation with periodic leg movements during sleep. J Sleep Res 2000;9:273-7.
113. MacFarlane JG, Shahal B, Mously C, Moldofsky H. Periodic K-alpha sleep EEG activity and periodic limb movements during sleep: comparisons of clinical features and sleep parameters. Sleep 1996;19:200-4.
114. Montplaisir J, Boucher S, Gosselin A, Poirier G, Lavigne G. Persistence of repetitive EEG arousals (K-alpha complexes) in RLS patients treated with L-DOPA. Sleep 1996;19:196-9.
115. HS.Monstad P, Guilleminault C. Cardiovascular changes associated with spontaneous and evoked K-complexes. Neurosci Lett 1999;263:211-3.
116. Heald S, Siebers RW, Maling TJ. The K-complex vasoconstrictor response: evidence for central vasomotor downregulation in borderline hypertension. J Hypertens Suppl 1989;7:S28-9.
117. Hornyak M, Cejnar M, Elam M, Matousek M, Wallin BG. Sympathetic muscle nerve activity during sleep in man. Brain 1991;114:1281-95.
118. Lofaso F, Goldenberg F, d'Ortho MP, Coste A, Harf A. Arterial blood pressure response to transient arousals from NREM sleep in nonapneic snorers with sleep fragmentation. Chest 1998;113:985-91.
119. Noll G, Elam M, Kunimoto M, Karlsson T, Wallin BG. Skin sympathetic nerve activity and effector function during sleep in humans. Acta Physiol Scand 1994;151:319-29.
120. Okada H, Iwase S, Mano T, Sugiyama Y, Watanabe T. Changes in muscle sympathetic nerve activity during sleep in humans. Neurology 1991;41:1961-6.
121. Sforza E, Jouny C, Ibanez V. Time course of arousal response during periodic leg movements in patients with periodic leg movements and restless legs syndrome. Clin Neurophysiol 2003;114:1116-24.
122. Sforza E, Juony C, Ibanez V. Time-dependent variation in cerebral and autonomic activity during periodic leg movements in sleep: implications for arousal mechanisms. Clin Neurophysiol 2002;113:883-91.
123. Sforza E, Nicolas A, Lavigne G, Gosselin A, Petit D, Montplaisir J. EEG and cardiac activation during periodic leg movements in sleep: support for a hierarchy of arousal responses. Neurology 1999;52:786-91.
124. EEG arousals: scoring rules and examples. Sleep 1992;15:173-84.
125. Schieber JP, Muzet A, Fernere PJ. [Characteristics of spontaneous transitory activation during slow and rapid sleep in man]. J Physiol (Paris) 1968;60(Suppl 2):542.
126. Terzano MG, Parrino L, Anelli S, Boselli M, Clemens B. Effects of generalized interictal EEG discharges on sleep stability: assessment by means of cyclic alternating pattern. Epilepsia 1992;33:317-26.
127. Terzano MG, Parrino L, Mennuni GF. Phasic events and microstructure of sleep. Consensus Conference. Lecce: Associazione Italiana di Medicina del Sonnon; 1997.
128. Parrino L, Smerieri A, Rossi M, Terzano MG. Relationship of slow and rapid EEG components of CAP to ASDA arousals in normal sleep. Sleep 2001;24:881-5.
129. Parrino L, Smerieri A, Spaggiari MC, Terzano MG. Cyclic alternating pattern (CAP) and epilepsy during sleep: how a physiological rhythm modulates a pathological event. Clin Neurophysiol 2000;111(Suppl 2):S39-46.
130. Parrino L, Spaggiari MC, Boselli M, Barusi R, Terzano MG. Effects of prolonged wakefulness on cyclic alternating pattern (CAP) during sleep recovery at different circadian phases. J Sleep Res 1993;2:91-5.
131. Ferri R, Parrino L, Smerieri A, et al. Non-linear EEG measures during sleep: effects of the different sleep stages and cyclic alternating pattern. Int J Psychophysiol 2002;43:273-86.
132. Ferrillo F, Gabarra M, Nobili L, et al. Comparison between visual scoring of cyclic alternating pattern (CAP) and computerized assessment of slow EEG oscillations in the transition from light to deep non-REM sleep. J Clin Neurophysiol 1997;14:210-6.
133. Halász P. Arousals without awakening-dynamic aspect of sleep. Physiol Behav 1993;54:795-802.
134. Halász P, Ujszászi J. Spectral features of evoked micro-arousals. In: Terzano MG, Hàlasz PL, Declerck AC, eds. Phasic events and dynamic organization of sleep. New York: Raven Press Ltd.; 1991:85-100.
135. Halasz P, Terzano M, Parrino L, Bodizs R. The nature of arousal in sleep. J Sleep Res 2004;13:1-23.
136. Terzano MG, Parrino L, Rosa A, Palomba V, Smerieri A. CAP arousals in the structural development of sleep: an integrative perspective. Sleep Med 2002;3:221-9.
137. Sallinen M, Kaartinen J, Lyytinen H. Is the appearance of mismatch negativity during stage 2 sleep related to the elicitation of K-complex? Electroencephalogr Clin Neurophysiol 1994;91:140-8.
138. Colrain IM, Di Parsia P, Gora J. The impact of prestimulus EEG frequency on auditory evoked potentials during sleep onset. Can J Exp Psychol 2000;54:243-54.
139. Perrin F, Garcia-Larrea L, Mauguiere F, Bastuji H. A differential brain response to the subject's own name persists during sleep. Clin Neurophysiol 1999;110:2153-64.
140. Perrin F, Bastuji H, Mauguiere F, Garcia-Larrea L. Functional dissociation of the early and late portions of human K-complexes. Neuroreport 2000;11:1637-40.
141. Pratt H, Berlad I, Lavie P. Oddball' event-related potentials and information processing during REM and non-REM sleep. Clin Neurophysiol 1999;110:53-61.
142. Voss U, Harsh J. Information processing and coping style during the wake/sleep transition. J Sleep Res 1998;7:225-32.
143. Butler RA. Effect of changes in stimulus frequency and intensity on habituation of the human vertex potential. J Acoust Soc Am 1968;44:945-50.
144. Butler RA. Frequency specificity of the auditory evoked response to simultaneously and successively presented stimuli. Electroencephalogr Clin Neurophysiol 1972;33:277-82.
145. Picton TW, Woods DL, Proulx GB. Human auditory sustained potentials. II. Stimulus relationships. Electroencephalogr Clin Neurophysiol 1978;45:198-210.
146. Halàsz P, Ujszàszi J. Spectral features of evoked micro-arousals. In: Declerck AC, ed. Phasic Events and Dynamic Organization of Sleep. New York: Raven Press; 1991:85-100.
147. Amzica F, Steriade M. The K-complex: its slow (<1-Hz) rhythmicity and relation to delta waves. Neurology 1997;49:952-9.
148. Ehrhart J, Ehrhart M, Muzet A, Schieber JP, Naitoh P. K-complexes and sleep spindles before transient activation during sleep. Sleep 1981;4:400-7.
149. Gaillard JM, Tissot R. EEG sleep studies of insomniacs under flunitrazepam treatment. Int Pharmacopsychiatry 1975;10:199-207.
150. Kubicki S, Haag-Wusthof C, Rohmel J, Herrmann WM, Scheuler W. Effect of lormetazepam, triazolam and flunitrazepam on rapid eye movements, K-complexes and sleep spindles in normal probands. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb 1987;18:61-7.
151. Naitoh P, Antony-Baas V, Muzet A, Ehrhart J. Dynamic relation of sleep spindles and K-complexes to spontaneous phasic arousal in sleeping human subjects. Sleep 1982;5:58-72.
152. Principe JC, Smith JR. Sleep spindle characteristics as a function of age. Sleep 1982;5:73-84.
153. Guazzelli M, Feinberg I, Aminoff M, Fein G, Floyd TC, Maggini C. Sleep spindles in normal elderly: comparison with young adult patterns and relation to nocturnal awakening, cognitive function and brain atrophy. Electroencephalogr Clin Neurophysiol 1986;63:526-39.
154. Wauquier A. Aging and changes in phasic events during sleep. Physiol Behav 1993;54:803-6.
155. Landolt HP, Dijk DJ, Achermann P, Borbély AA. Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men. Brain Res 1996;738:205-12.
156. Wei HG, Riel E, Czeisler CA, Dijk DJ. Attenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects. Neurosci Lett 1999;260:29-32.
157. Nicolas A, Petit D, Rompre S, Montplaisir J. Sleep spindle characteristics in healthy subjects of different age groups. Clin Neurophysiol 2001;112:521-7.
158. Kubicki S, Scheuler W, Jobert M, Pastelak-Price C. The effect of age on sleep spindle and K complex density. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb 1989;20:59-63.
159. Colrain IM, Crowley K, Nicholas CL, et al. Averaged evoked K-complex amplitude correlates with aging over the adult life-span. Sleep 2003;25:A662.
160. Steriade M, Dossi RC, Nunez A. Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep delta waves: cortically induced synchronization and brainstem cholinergic suppression. J Neurosci 1991;11:3200-17.
161. Steriade M, Nunez A, Amzica F. A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J Neurosci 1993;13:3852-65.
162. Salisbury D, Squires NK. Response properties of long-latency event-related potentials evoked during NREM sleep. J Sleep Res 1993;2:232-40.
163. Bastuji H, Garcia-Larrea L, Franc C, Mauguiere F. Brain processing of stimulus deviance during slow-wave and paradoxical sleep: a study of human auditory evoked responses using the oddball paradigm. J Clin Neurophysiol 1995;12:155-67.
164. Iramina K, Ueno S. Source estimation of spontaneous MEG activity and auditory evoked responses in normal subjects during sleep. Brain Topogr 1996;8:297-301.
165. Wennberg RA, Lozano AM. Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodes. Clin Neurophysiol 2003;114:1403-18.
166. Velasco M, Eugenia-Diaz-de Leon A, Marquez I, et al. Temporo-spatial correlations between scalp and centromedian thalamic EEG activities of stage II slow wave sleep in patients with generalized seizures of the cryptogenic Lennox-Gastaut syndrome. Clin Neurophysiol 2002;113:25-32.
167. Amzica F, Steriade M. Cellular substrates and laminar profile of sleep K-complex. Neuroscience 1998;82:671-86.
168. Numminen J, Makela JP, Hari R. Distributions and sources of magnetoencephalographic K-complexes. Electroencephalogr Clin Neurophysiol 1996;99:544-55.
169. Lu ST, Kajola M, Joutsiniemi SL, Knuutila J, Hari R. Generator sites of spontaneous MEG activity during sleep. Electroencephalogr Clin Neurophysiol 1992;82:182-96.
170. Steriade M, Amzica F, Contreras D. Synchronization of fast (30-40Hz) spontaneous cortical rhythms during brain activation. J Neurosci 1996;16:392-417.
171. Achermann P, Borbely AA. Low-frequency (< 1 Hz) oscillations in the human sleep electroencephalogram. Neuroscience 1997;81:213-22.
172. Steriade M, Nunez A, Amzica F. Intracellular analysis of relations between the slow (1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram. J Neurosci 1993;13:3266-83.
173. Timofeev I, Steriade M. Low-frequency rhythms in the thalamus of intact-cortex and decorticated cats. J Neurophysiol 1996;76:4152-68.
174. Amzica F, Steriade M. Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation. J Neurosci 1995;15:4658-77.
175. Amzica F, Massimini M. Glial and neuronal interactions during slow wave and paroxysmal activities in the neocortex. Cereb Cortex 2003;12:1101-13.
176. Jones BE. Noradrenergic locus coeruleus neurons: their distant connections and their relationship to neighboring (including cholinergic and GABAergic) neurons of the central gray and reticular formation. Prog Brain Res 1991;88:15-30.
177. Jones BE. The organization of central cholinergic systems and their functional importance in sleep-waking states. Prog Brain Res 1993;98:61-71.
178. Jones BE, Muehlethaler M. Cholinergic and GABAergic neurons in the basal forebrain: Role in cortical activation. In: Lydic R, Baghdoyan HA, eds. Handbook of Behavioral State Control: Cellular and Molecular Mechanisms. Boca Raton: CRC Press; 1999:213-33.
179. Moruzzi G, Magoun HW. Brain stem reticular formation and activation of the EEG. J Neuropsychiatry Clin Neurosci 1949;7:251-67.
180. Shute CC, Lewis PR. The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections. Brain 1967;90:497-520.
181. Manns ID, Alonso A, Jones BE. Discharge properties of juxtacellularly labeled and immunohistochemically identified cholinergic basal forebrain neurons recorded in association with the electroencephalogram in anesthetized rats. J Neurosci 2000;20:1505-18.
182. Manns ID, Alonso A, Jones BE. Rhythmically discharging basal forebrain units comprise cholinergic, GABAergic, and putative glutamatergic cells. J Neurophysiol 2003;89:1057-66.