Effect of estrogen, tamoxifen and epidermal growth factor on the transcriptional regulation of vascular endothelial growth factor in breast cancer cells

Anticancer Research

Volumn 24, Issue 6, 2004, Pages 3961-3964

  Lee, Jeong Eon ^a   Chung, Ki Wook ^c   Han, Wonshik ^a   Kim, Sung Won ^b   Kim, Seok Won ^a   Shin, Hyuk Jai ^a   Bae, Ji Yeoun ^a   Noh, Dong Young ^a,d  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c National Cancer Center   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Breast cancer; Estrogen; Estrogen receptor (ER); MB MDA 231; MCF 7; Tamoxifen; VEGF

Indexed keywords

EPIDERMAL GROWTH FACTOR; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; PROGESTERONE RECEPTOR; PROTEIN BCL 2; TAMOXIFEN; VASCULOTROPIN; ESTRADIOL; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN; VASCULOTROPIN A;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VASCULARIZATION; BIOSYNTHESIS; BREAST TUMOR; DENSITOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; DENSITOMETRY; EPIDERMAL GROWTH FACTOR; ESTRADIOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TAMOXIFEN; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 14944378653     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Locopo N, Faneur M and Gasparini G: Clinical significance of angiogenic factors in breast cancer. Breast Cancer Res Treat 52: 150-173, 1998.
2. Ferrara N and Davis-Smith T: The biology of vascular endothelial growth factor. Endocr Rev 18: 4-25, 1997.
3. Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. NEJM 324: 1-8, 1991.
4. Manders P, Beex LV, Tjan-Heijnen VC, Span PN and Sweep CG: Vascular endothelial growth factor is associated with the efficacy of endocrine therapy in patients with advanced breast carcinoma. Cancer 98: 2125-2132, 2003.
5. Foekens JA, Peters HA, Grebenchtchikov N, Look MP, Meijer-van Gelder ME, Geurts-Moespot A, van der Kwast TH, Sweep CG and Klijn JG: High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer. Cancer Res 61: 5407-5414, 2001.
6. Ferrara N: Vascular endothelial growth factor: molecular and biological factor. Curr Top Microbiol Immunol 237: 1-30, 1999.
7. 145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272: 7151-7158, 1997.
8. Coradini D, Pellizzaro C, Speranza A and Daidone MG: Hypoxia and estrogen receptor profile influence the responsiveness of human breast cancer cells to estradiol and antiestrogens. Cell Mol Life Sci 61: 76-82, 2004.
9. Taker H, Lee ES and Jordan VC: In vitro regulation of vascular endothelial growth factor by estrogens and antiestrogens in estrogen-receptor positive breast cancer. Breast Cancer 9: 39-42, 2002.
10. Garvin S and Dabrosin C: Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Res 63: 8742-8748, 2003.
11. Ruohola JK, Valve EM, Karkkainen MJ, Joukov V, Alitalo K and Harkonen PL: Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol Cell Endocrinol 149: 29-40, 1999.
12. Hyder SM, Huang JC, Nawaz Z, Boettger-Tong H, Makela S, Chiappetta C and Stancel GM: Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environ Health Perspect 108 Suppl 5: 785-790, 2000.
13. Bogin L and Degani H: Hormonal regulation of VEGF in orthotopic MCF7 human breast cancer. Cancer Res 62: 1948-1951, 2002.
14. Hyder SM, Nawaz Z, Chiappetta C and Stancel GM: Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor. Cancer Res 60: 3183-3190, 2000.
15. Kuiper GGJM, Enmark E and Huikko MP: Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 138: 5925-5930, 1996.
16. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson J-A and Smithies O: Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc Natl Acad Sci USA 95: 15677-15682, 1998.
17. Buteau-Lozano H, Ancelin M, Lardeux B, Milanini J and Perrot-Applanat M: Transcriptional regulation of vascular endothelial growth factor by estradiol and tamoxifen in breast cancer cells: a complex interplay between estrogen receptors α and β. Cancer Res 62: 4977-4984, 2002.
18. Maity A, Sall W, Koch CJ, Oprysko PR and Evans SM: Low pO2 and β-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia. Breast Cancer Res Treat 67: 51-60, 2001.
19. Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC and Taylor RN: Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β. Proc Natl Acad Sci USA 97: 10972-10977, 2000.
20. Ali SH, O'Donnell AL, Balu D, Pohl MB, Seyler MJ, Mohamed S, Mousa S and Dandona P: Estrogen receptor-α in the inhibition of cancer growth and angiogenesis. Cancer Res 60: 7094-7098, 2000.
21. Mueller MD, Pritts EA, Zaloudek CJ, Dreher E and Taylor RN: Regulation of vascular endothelial growth factor by tamoxifen in vitro and in vivo. Gynecol Obstet Invest 55: 119-124, 2003.
22. Stoica GE, Franke TF, Moroni M, Mueller S, Morgan E, Iann MC, Winder AD, Reiter R, Wellstein A, Martin MB and Stoica A: Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway. Oncogene 22: 7998-8011, 2003.