FHR-4A: A new factor H-related protein is encoded by the human FHR-4 gene

European Journal of Human Genetics

Volumn 13, Issue 3, 2005, Pages 321-329

  Józsi, Mihály ^a   Richter, Heiko ^a   Löschmann, Ina ^a   Skerka, Christine ^a   Buck, Friedrich ^b   Beisiegel, Ulrike ^c   Erdei, Anna ^d   Zipfel, Peter F ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Apoprotein; CCP domain; Complement; Factor H related; FHR 4

Indexed keywords

AMINO ACID; APOLIPOPROTEIN; COMPLEMENT FACTOR H; COMPLEMENTARY DNA; DIMER; ISOPROTEIN; MESSENGER RNA; PEPTIDE; PLASMA PROTEIN; PROTEIN FHR 4A; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA ISOLATION; DNA SEQUENCE; EXON; GENE DUPLICATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MOLECULAR SIZE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBSERVATION; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN GLYCOSYLATION; PROTEIN SECRETION; TANDEM REPEAT;

AMINO ACID SEQUENCE; APOLIPOPROTEINS; BASE SEQUENCE; BLOTTING, WESTERN; COMPLEMENT FACTOR H; GENE LIBRARY; GLYCOPROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 14944365484     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201324     Document Type: Article

References (22)

1. Zipfel PF, Jokiranta TS, Hellwage J, Koistinen V, Meri S: The Factor H protein family. Immunopharmacology 1999; 42: 53-60.
2. Schwaeble W, Zwirner J, Schulz TF, Linke RP, Dierich MP, Weiss EH: Human complement factor H: expression of an additional truncated gene product of 43 kDa in human liver. Eur J Immunol 1987; 17: 1485-1489.
3. Skerka C, Moulds JM, Taillon-Miller P, Hourcade D, Zipfel PF: The human Factor H-related gene 2 (FHR2): structure and linkage to the coagulation Factor XIIIb gene. Immunogenetics 1995; 42: 268-274.
4. Rodríguez de Córdoba S, Díaz-Guillén MA, Heine-Suñer D: An integrated map of the human regulator of complement activation (RCA) gene cluster on 1q32. Mol Immunol 1999; 36: 803-808.
5. Male DA, Ormsby RJ, Ranganathan S, Giannakis E, Gordon DL: Complement Factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes. Mol Immunol 2000; 37: 41-52.
6. McRae JL, Murphy BE, Eyre HJ, Sutherland GR, Crawford J, Cowan PJ: Location and structure of the human FHR-5 gene. Genetica 2002; 114: 157-161.
7. Zipfel PF, Skerka C: Complement Factor H and related proteins: an expanding family of complement-regulatory proteins? Immunol Today 1994; 15: 121-126.
8. Majno SA, Jokiranta TS, Hühn M, Seeberger H, Hellwage J: The human Factor H-related protein 1 (FHR-1) binds to C3b and heparin: implications for a regulatory role on the level of C3. Mol Immunol 2003; 40: 174, (abstract).
9. Hellwage J, Jokiranta TS, Koistinen V, Vaarala O, Meri S, Zipfel PF: Functional properties of complement Factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin. FEBS Lett 1999; 462: 345-352.
10. McRae JL, Cowan PJ, Power DA et al: Human Factor H-related protein 5 (FHR-5). A new complement-associated protein. J Biol Chem 2001; 276: 6747-6754.
11. Prodinger WM, Hellwage J, Spruth M, Dierich MP, Zipfel PF: The C-terminus of Factor H: monoclonal antibodies inhibit heparin binding and identify epitopes common to Factor H and Factor H-related proteins. Biochem J 1998; 331: 41-47.
12. Duthy TG, McRae JL, Griggs KM, Murphy BF, Gordon DL: Functional characterization of human Factor H-related protein 5 (FHR-5) reveals heparin binding and novel cofactor activity. Int Immunopharmacol 2002; 2: 1269, (abstract).
13. Hellwage J, Jarva H, Zipfel PF, Meri S: Factor H-related proteins interact with C-reactive protein. Immunopharmacology 2000; 49: 70, (abstract).
14. Kotarsky H, Hellwage J, Johnsson E et al: Identification of a domain in human Factor H and Factor H-like protein-1 required for the interaction with streptococcal M proteins. J Immunol 1998; 160: 3349-3354.
15. Murphy B, Georgiou T, Machet D, Hill P, McRae J: Factor H-related protein-5: a novel component of human glomerular immune deposits. Am J Kidney Dis 2002; 39: 24-27.
16. Krushkal J, Bat O, Gigli I: Evolutionary relationships among proteins encoded by the regulator of complement activation gene cluster. Mol Biol Evol 2000; 17: 1718-1730.
17. Vik DP, Munoz-Canoves P, Kozono H, Martin LG, Tack BF, Chaplin DD: Identification and sequence analysis of four complement Factor H-related transcripts in mouse liver. J Biol Chem 1990; 265: 3193-3201.
18. Ren G, Doshi M, Hack BK, Alexander JJ, Quigg RJ: Isolation and characterization of a novel rat Factor H-related protein that is upregulated in glomeruli under complement attack. J Biol Chem 2002; 277: 48351-48358.
19. Dahmen A, Kaidoh T, Zipfel PF, Gigli I: Cloning and characterization of a cDNA representing a putative complement-regulatory plasma protein from barred sand bass (Parablax neblifer). Biochem J 1994; 301: 391-397.
20. Zipfel PF, Kemper C, Dahmen A, Gigli I: Cloning and recombinant expression of a barred sand bass (Paralabrax nebulifer) cDNA. The encoded protein displays structural homology and immunological crossreactivity to human complement/cofactor related plasma proteins. Dev Comp Immunol 1996; 20: 407-416.
21. Skerka C, Hellwage J, Weber W et al: The human Factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins. J Biol Chem 1997; 272: 5627-5634.
22. Hellwage J, Skerka C, Zipfel PF: Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4). Immunopharmacology 1997; 38: 149-157.