Introduction of a high-energy diet acutely up-regulates hypothalamic cocaine and amphetamine-regulated transcript, Mc4R and brown adipose tissue uncoupling protein-1 gene expression in male sprague-dawley rats

Journal of Neuroendocrinology

Volumn 17, Issue 1, 2005, Pages 10-17

  Archer, Zoe A ^a   Rayner, D V ^a   Duncan, J S ^a   Bell, L M ^a   Mercer, J G ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Diet induced obesity; Energy balance; Neuropeptides

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; ENERGY BALANCE; FATTY ACID BLOOD LEVEL; FOOD COMPOSITION; FOOD INTAKE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; IN SITU HYBRIDIZATION; INSULIN BLOOD LEVEL; MALE; NONHUMAN; NORTHERN BLOTTING; OBESITY; PRIORITY JOURNAL; RAT; RAT STRAIN; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ANIMAL FEED; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CARRIER PROTEINS; ENERGY INTAKE; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION; HYPOTHALAMUS; INSULIN; ION CHANNELS; LEPTIN; MALE; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 4; UP-REGULATION;

EID: 14944361139     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01269.x     Document Type: Article

References (34)

1. Blundell JE, Cooling J. High-fat and low-fat (behavioural) phenotypes: biology or environment? Proc Nutr Soc 1999; 58: 773-777.
2. Blundell JE, Cooling J. Routes to obesity, phenotypes, food choices and activity. Br J Nutr 2000; 83: S33-S38.
3. Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here? Science 2003; 299: 853-855.
4. Friedman JM. A war on obesity, not the obese. Science 2003; 299: 856-858.
5. Archer ZA, Rayner DV, Rozman J, Klingenspor M, Mercer JG. Normal distribution of body weight gain in male Sprague-Dawley rats fed a high energy (HE) diet. Obes Res 2003; 11: 1376-1383.
6. Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am J Physiol 2000; 279: E838-E845.
7. Peterson JI, Young DS. Evaluation of the hexokinase/glucose-6-phosphate dehydrogenase method of determination of glucose in urine. Anal Biochem 1968; 23: 301-316.
8. Matsubara C, Nishikawa Y, Yoshida Y, Takamura K. A spectro-photometric method for the determination of free fatty acids in serum using acyl-coenzyme A synthetase and acyl-coenzyme A oxidase. Anal Biochem 1983; 130: 128-133.
9. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973; 19: 476-482.
10. Trayhurn P, Duncan JS, Rayner DV. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J 1995; 311: 729-733.
11. Trayhurn P, Duncan JS, Nestor A, Thomas MEA, Eastmend NC, Rayner DV. Rapid chemiluminescent detection of mRNAs on Northern blots with digoxigenin end-labelled oligonucleotides. Electrophoresis 1995; 16: 341-344.
12. Simmons DM, Arriza JL, Swanson LW. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes. J Histotechnol 1989; 12: 169-181.
13. Mercer JG, Lawrence CB, Beck B, Burlet A, Atkinson T, Barrett P. Hypothalamic NPY and Prepro-NPY mRNA in Djungarian hamsters: effects of food deprivation and photoperiod. Am J Physiol 1995; 269: R1099-R1106.
14. Mercer JG, Moar KM, Ross AW, Hoggard N, Morgan PJ. Photoperiod regulates arcuate nucleus POMC, AgRp and leptin receptor mRNA in Siberian hamster hypothalamus. Am J Physiol 2000; 278: R271-R281.
15. Higuchi H, Yang HY, Sabol SL. Rat neuropeptide Y precursor gene expression: mRNA structure, tissue distribution and regulation by glucocorticoids, cyclic AMP and phorbol. Ester J Biol Chem 1988; 263: 6288-6295.
16. Adam CL, Moar KM, Logie TJ, Ross AW, Barrett P, Morgan PJ, Mercer JG. Photoperiod regulates growth, puberty and hypothalamic neuropeptide and receptor gene expression in female Siberian hamsters. Endocrinology 2000; 141: 4349-4356.
17. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 2nd edn. London: Academic Press, 1986.
18. Diggle PJ, Liarg K-Y, Zeger SL. Analysis of longitudinal data. In: Atkinson AC, Copas JB, Pierce DA, Scervish MJ, Titterington DM, eds. Oxford Science Publications Series, vol. 13, section 1.5. Oxford: Clarendon Press, 1994: 18-21.
19. National Diet and Nutrition Survey. Report of the Diet and Nutrition Survey. Young People Aged 4-18 Years, vol. 1. London: HMSO, 1997.
20. Rousset S, Alves-Guerra M-C, Mozo J, Miroux B, Cassard-Doulcier A-M, Bouillaud F, Ricquier D. The biology of mitochondrial uncoupling proteins. Diabetes 2004; 53 (Suppl. 1): S130-S135.
21. Seeley RJ, Drazen DL, Clegg DJ. The critical role of the melanocortin system in the control of energy balance. Annu Rev Nutr 2004; 24: 133-149.
22. Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD. Melanoncortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nature Neurosci 2001; 4: 605-611.
23. Levin BE, Dunn-Meynell AA. Reduced central leptin sensitivity in rats with diet-induced obesity. Am J Physiol 2002; 283: R941-R948.
24. Levin BE, Dunn-Meynell AA. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am J Physiol 1997; 272: R1365-R1370.
25. Archer ZA, Rayner DV, Mercer JG. Hypothalamic gene expression is altered in underweight but obese juvenile mate Sprague-Dawley rats fed a high energy diet. J Nutr 2004; 134: 1369-1374.
26. Rohner-Jeanrenaud F, Craft LS, Bridwell J, Suter TM, Tinsley FC, Smiley DL, Burkhart DR, Statnick MA, Heiman ML, Ravussin E, Caro JF. Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats. Int J Obes Relat Metab Disord 2002; 26: 143-149.
27. Wang C, Billington CJ, Levine AS, Kotz CM. Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression. Neuroreport 2000; 11: 3251-3255.
28. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 1998; 21: 1375-1385.
29. Hunter RG, Philpot K, Vicentic A, Dominguez G, Hubert GW, Kuhar MJ. CART in feeding and obesity. Trends Endocrinol Metab 2004; 15: 454-459.
30. Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen Y-F, Hsiung HM, Koster A. Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology 2001; 142: 4394-4400.
31. Challis BG, Yeo GS, Farooqi IS, Luan J, Aminian S, Halsall DJ, Keogh JM, Wareham NJ, O'Rahilly S. The CART gene and human obesity: mutational analysis and population genetics. Diabetes 2000; 49: 872-875.
32. del Giudice EM, Santoro N, Cirillo G, D'Urso L, Di Toro R, Perrone L. Mutation screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes 2001; 50: 2157-2160.
33. Blundell JE, Burley VJ. Evaluation of the satiating power of dietary fat in man. In: Oomura Y, Baba S, Shimazu T, eds. Progress in Obesity Research 1990. London: J. Libbey & Sons, 1991: 453-457.
34. Prentice AM, Poppitt SD. Energy density and its role in the control of food intake: evidence from metabolic and community studies. Appetite 1996; 26: 153-174.