What are effective therapies for Clostridium difficile-associated diarrhea?

Journal of Family Practice

Volumn 54, Issue 2, 2005, Pages 176-178

  Ohl, Michael E ^a   Stevermer, James J ^a   Meadows, Susan ^a  

^a University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLESTYRAMINE; METRONIDAZOLE; PROBIOTIC AGENT; RIFAMPICIN; VANCOMYCIN; ANTIINFECTIVE AGENT;

CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE; CONSTIPATION; DIARRHEA; DRUG DOSE REDUCTION; DRUG INDICATION; HUMAN; NONHUMAN; REVIEW; SACCHAROMYCES BOULARDII; XEROSTOMIA; BACTERIAL INFECTION; DRUG EFFECT;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DIARRHEA; HUMANS; METRONIDAZOLE; VANCOMYCIN;

EID: 14944352830     PISSN: 00943509     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (8)

1. Teasley DG, Gerding DN, Olson MM, et al. Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis. Lancet 1983; 2:1043-1046.
2. Wenisch C, Parschalk B, Hasenhundl M, Hirschl AM, Graninger W. Comparison of vancomycin, teicoplanin, metronidazole, and fusidic acid for the treatment of Clostridium difficile-associated diarrhea. Clin Infect Dis 1996; 22:813-818.
3. Fekety R, Silva J, Kauffman C, Buggy B, Deery HG. Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens. Am J Med 1989; 86:15-19.
4. Bolton RP, Culshaw MA. Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut 1986; 27:1169-1172.
5. Bartlett JG, Tedesco FJ, Shull S, Lowe B, Chang T. Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis. Gastroenterology 1980; 78:431-434.
6. McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994; 271:1913-1918.
7. Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 1997; 92:739-750.
8. Hurley, B. W. and Nguyen, C. C. Drug therapy: use of antimicrobial agents as first-line drug therapy for CDAD. PIER: Clinical Guidance from ACP, 2004. Available at: pier.acponline.org/physicians/diseases/d320/d320.html. Accessed on July 14, 2004.