Preliminary study on androgen dependence of calcitonin gene-related peptide in rat penis

Asian Journal of Andrology

Volumn 7, Issue 1, 2005, Pages 55-59

  Shen, Zhou Jen ^a   Chen, Shan Wen ^a   Lu, Ying Li ^b   Li, Liao Yuan ^a   Zhou, Xie Lai ^a   Zhang, Ming Guang ^a   Chen, Zhao Dian ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Androgens; Calcitonin gene related peptide; Neurotransmitters; Penis; Rat

Indexed keywords

ANDROGEN; ANDROSTANOLONE; CALCITONIN GENE RELATED PEPTIDE; FINASTERIDE; NEUROTRANSMITTER; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CASTRATION; COMPUTER AIDED DESIGN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS CAVERNOSUM; HORMONE DEPENDENCE; IMAGE ANALYSIS; IMAGING SYSTEM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE FIBER; NONHUMAN; PENIS; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RANDOMIZATION; RAT; TESTOSTERONE BLOOD LEVEL;

ANDROGENS; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; DIHYDROTESTOSTERONE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; PENIS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE;

EID: 14944348489     PISSN: 1008682X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2005.00003.x     Document Type: Article

References (19)

1. Takane KK, Wilson JD, McPhaul MJ. Decreased levels of the androgen receptor in the mature rat phallus are associated with decreased levels of androgen receptor messenger ribonucleic acid. Endocrinology 1991; 129: 1093-100.
2. Mills TM, Stopper VS, Reilly CM. Sites of androgenic regulation of cavernosal blood pressure during penile erection in the rat. Int J Impot Res 1996; 8: 29-34.
3. Mills TM, Wiedmeier VT, Stopper VS. Androgen maintenance of erectile function in the rat penis. Biol Reprod 1992; 46: 342-8.
4. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993; 75: 1273-86.
5. Reilly CM, Lewis RW, Stopper VS, Mills TM. Androgenic maintenance of the rat erectile response via a non-nitric-oxide-dependent pathway. J Androl 1997; 18: 588-94.
6. Stief CG, Bernard F, Bosch R, Aboseif S, Wetterauer U, Lue TF, et al. Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys. Urology 1993; 41: 397-401.
7. Champion HC, Wang R, Santiago JA, Murphy WA, Coy DH, Kadowitz PJ, et al. Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the feline erection model. J Androl 1997; 18: 513-21.
8. Stief CG, Wetterauer U, Schaebsdau FH, Jonas U. Calcitonin gene-related peptide: a possible role in human penile erection and its therapeutic application in impotent patients. J Urol 1991; 146: 1010-4.
9. Wagner CK, Popper P, Ulibarri C, Clemens LG, Micevych PE. Calcitonin gene-related peptide-like immunoreactivity in spinal motoneurons of the male mouse is affected by castration and genotype. Brain Res 1994; 647: 37-43.
10. Gillardon F, Morano I, Ganten U, Zimmermann M. Regulation of calcitonin gene-related peptide mRNA expression in the hearts of spontaneously hypertensive rats by testosterone. Neurosci Lett 1991; 125: 77-80.
11. McNeill DL, Papka RE, Harris CH. CGRP immunoreactivity and NADPH-diaphorase in afferent nerves of the rat penis. Peptides 1992; 13: 1239-46.
12. Shabsigh R. The effects of testosterone on the cavernous tissue and erection. World J Urol 1997; 15: 21-6.
13. Rousseau L, Dupont A, Labrie F, Couture M. Sexuality changes in prostate cancer patients receiving antihormonal therapy combining the antiandrogen flutamide with medical (LHRH agonist) or surgical castration. Arch Sex Behav 1988; 17: 87-98.
14. Mills TM, Reilly CM, Lewis RW. Androgens and penile erection. J Androl 1996; 17: 633-8.
15. Lundberg JM, Franco-Cereceda A, Hua X, Hokfelt T, Fischer JA. Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol 1985; 108: 315-9.
16. Uddman R, Edvinsson L, Ekbald E, Hakanson R, Sundler F. Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects. Regul Pept 1986; 15: 1-23.
17. Gibson SJ, Polak JM, Giaid A, Hamid QA, Kar S, Jones PM, et al. Calcitonin gene-related peptide messenger RNA is expressed in sensory neurones of the dorsal root ganglia and also in spinal motoneurones in man and rat. Neurosci Lett 1988; 91: 283-8.
18. Wimalawansa SJ. Age-related increase of calcitonin gene-related peptide in rat thyroid and circulation. Peptides 1991; 12: 1143-7.
19. Marshall I. Mechanism of vascular relaxation by the calcitonin gene-related peptide. Ann N Y Acad Sci 1992; 657: 204-15.