Benzo[b]thiophenesulphonamide 1,1-dioxide derivatives inhibit tNOX activity in a redox state-dependent manner

British Journal of Cancer

Volumn 92, Issue 4, 2005, Pages 690-695

  Encio I ^a   Morre D J ^b   Villar, R ^a   Gil, M J ^a   Martinez Merino V ^a  

^a PUBLIC UNIVERSITY OF NAVARRE   (Spain)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Antineoplasic drugs; benzo b thiophenesulphonamides; ECTO NOX; Redox state; Tumour associated NADH oxidase

Indexed keywords

1 (4 CHLOROPHENYL) 3 (4 METHYLPHENYLSULFONYL)UREA; 6 [N (2 PHENYLETHYL)]BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE; BENZO[B]THIOPHENESULFONAMIDE 1,1 DIOXIDE DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; CYTOTOXIC AGENT; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BTS 1 COMPOUND; BTS 2 COMPOUND; BTS-1 COMPOUND; BTS-2 COMPOUND; ENZYME INHIBITOR; OXIDOREDUCTASE; SULFONAMIDE; THIOPHENE DERIVATIVE; TUMOR ASSOCIATED NADH OXIDASE; TUMOR PROTEIN; TUMOR-ASSOCIATED NADH OXIDASE;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL STRAIN HT29; CELL STRAIN K 562; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPOPHILICITY; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NEOPLASM; OXIDATION REDUCTION REACTION;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; HUMANS; NADH, NADPH OXIDOREDUCTASES; NEOPLASM PROTEINS; NEOPLASMS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SULFONAMIDES; THIOPHENES; TUMOR CELLS, CULTURED;

EID: 14944347557     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602383     Document Type: Article

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