Measurement of 3-hydroxyisovaleric acid in urine of biotin-deficient infants and mice by HPLC

Journal of Nutrition

Volumn 135, Issue 3, 2005, Pages 615-618

  Watanabe, Toshiaki ^a   Oguchi, Ken Ichi ^a   Ebara, Shuhei ^a   Fukui, Toru ^b  

^a UNIVERSITY OF HYOGO   (Japan)

^b Byotai Seiri Laboratory   (Japan)

Author keywords

3 hydroxyisovaleric acid; Biotin deficiency; HPLC; Methylcrotonyl CoA carboxylase; Urine

Indexed keywords

3 HYDROXYISOVALERIC ACID; BIOTIN; FATTY ACID; HEXANE; HYDRAZINE DERIVATIVE; ISOVALERIC ACID; METHYLCROTONOYL COENZYME A CARBOXYLASE; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL MILK; DERIVATIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFANT FEEDING; MOUSE; NONHUMAN; PEDIATRICS; URINE LEVEL; VITAMIN DEFICIENCY;

EID: 14944341724     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.3.615     Document Type: Article

References (19)

1. Mock, D. M., DeLorimer, A. A., Liebman, W. M., Sweetman, L. & Baker, H. (1981) Biotin deficiency: an unusual complication of parenteral alimentation. N. Engl. J. Med. 304: 820-823.
2. Wolf, B. & Feldman, G. L. (1982) The biotin-dependent carboxylase deficiencies. Am. J. Hum. Genet. 34: 699-716.
3. Mock, N. I., Malik, M. I., Stumbo, P. J., Bishop, W. P. & Mock, D. M. (1997) Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased biotin status in experimental biotin deficiency. Am. J. Clin. Nutr. 65: 951-958.
4. Mock, D. M., Henrich-Shell, C. L., Carnell, N., Stumbo, P. & Mock, N. I. (2004) 3-Hydroxypropionic acid and methylcitric acid are not reliable indicators of marginal biotin deficiency in humans. J. Nutr. 134: 317-320.
5. Mock, D. M., Henrich, C. L., Carnell, N. & Mock, N. I. (2002) Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am. J. Clin. Nutr. 76: 1061-1068.
6. Watanabe, T. (1983) Teratogenic effects of biotin deficiency in mice. J. Nutr. 113: 574-581.
7. Japanese Prime Minister's Office (1980) The Standards Related to the Care and Management of Experimental Animals. Notification No. 6, March 27.
8. Watanabe, T. & Fukui, T. (1998) Low biotin content of infant formulas made in Japan. Food Add. Contam. 15: 619-625.
9. Higuchi, R., Noda, E., Koyama, Y., Shirai, T., Horino, A., Juri, T. & Koike, M. (1996) Biotin deficiency in an infant fed with amino acid formula and hypoallergenic rice. Acta Paediatr. 85: 872-874.
10. Miwa, H., Yamamoto, M., Nishida, T., Nunoi, K. & Kikuchi, M. (1987) High-performance liquid chromatographic analysis of serum long-chain fatty acids by direct derivatization method. J. Chromatogr. 416: 237-245.
11. Miwa, H. & Yamamoto, M. (1987) High-performance liquid chromatographic analysis of serum short-chain fatty acids by direct derivatization. J. Chromatogr. 421: 33-41.
12. Stokke, O., Eldjam, L., Jellum, E., Pande, H. & Waaler, P. E. (1972) Beta-methylcrotonyl-CoA carboxylase deficiency: a new metabolic error in leucine degradation. Pediatrics 49: 726-735.
13. Mock, D. M., Jackson, H., Lankford, G. L., Mock, N. I. & Weintraub, S. T. (1989) Quantification of urinary 3-hydroxyisovaleric acid using deuterated 3-hydroxyisovaleric acid as internal standard. Biomed. Environ. Mass Spectrom. 18: 652-656.
14. Teran-Garcia, M., Ibarra, I. & Velazquez, A. (1998) Urinary organic acids in infant malnutrition. Pediatr. Res. 44: 386-391.
15. D'Amboise, M. & Gendreau, M. (1979) Isocratic separation of human blood plasma long chain free fatty acid derivatives by reversed phase liquid chromatography. Anal. Lett. 12: 381-395.
16. Yamaguchi, M., Matsunaga, R., Hara, S., Nakamura, M. & Ohkura, Y. (1986) Highly sensitive determination of free fatty acids in human serum by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 375: 27-35.
17. Mock, D. M., Quirk, J. G. & Mock, N. I. (2002) Marginal biotin deficiency during normal pregnancy. Am. J. Clin. Nutr. 75: 295-299.
18. Chastain, J. L., Bowers-Komro, D. M. & McCormick, D. B. (1985) High-performance liquid chromatography of biotin and analogues. J. Chromatogr. 330: 153-158.
19. Zempieni, J., McCormick, D. B. & Mock, D. M. (1997) Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-/-sulfoxide in human urine. Am. J. Clin. Nutr. 65: 508-511.