Intracellular localization and antiviral property of canine Mx proteins

Journal of Interferon and Cytokine Research

Volumn 25, Issue 3, 2005, Pages 169-173

  Nakamura, Teppei ^a   Asano, Atsushi ^a   Okano, Shinya ^a   Ko, Jae Hong ^a   Kon, Yasuhiro ^b   Watanabe, Tomomasa ^a   Agui, Takashi ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; COMPLEMENTARY DNA; INTERFERON; INTERFERON INDUCING AGENT; MESSENGER RNA; MYXOVIRUS RESISTANCE PROTEIN; POLYCYTIDYLIC ACID; POLYINOSINIC ACID;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CELL STRAIN 3T3; CELLULAR DISTRIBUTION; CYTOPLASM; DOG; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; RNA VIRUS; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTIVIRAL AGENTS; BALB 3T3 CELLS; BASE SEQUENCE; CELL LINE; CYTOPATHOGENIC EFFECT, VIRAL; CYTOPLASM; DNA, COMPLEMENTARY; DOGS; GENE EXPRESSION; GTP-BINDING PROTEINS; INTERFERON INDUCERS; MICE; POLY I-C; RECOMBINANT PROTEINS; RNA, MESSENGER; SUBCELLULAR FRACTIONS; TRANSFECTION; VESICULAR STOMATITIS-INDIANA VIRUS;

RNA VIRUSES; VESICULAR STOMATITIS VIRUS;

EID: 14844349233     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2005.25.169     Document Type: Article

References (28)

1. GOODBOURN, S., DIDCOCK, L., and RANDALL, R.E. (2000). Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures. J. Gen. Virol. 81, 2341-2364.
2. STARK, G.R., KERR, I.M., WILLIAMS, B.R., SILVERMAN, R H., and SCHREIBER, R.D. (1998). How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264.
3. HALLER, O., and KOCHS, G. (2002). Interferon-induced Mx proteins: dynamin-like GTPases with antiviral activity. Traffic 3, 710-717.
4. NAKAYAMA, M., NAGATA, K., KATO, A., and ISHIHAMA, A. (1991). Interferon-inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J. Biol. Chem. 266, 21404-21408.
5. DI PAOLO, C., HEFTI, H.P., MELI, M., LANDIS, H., and PAVLOVIC, J. (1999). Intramolecular back-folding of the carboxyl-terminal end of MxA protein is a prerequisite for its oligomerization. J. Biol. Chem. 274, 32071-32078.
6. MELÉN, K., RONNI, T., BRONI, B., KRUG, R. M., VON, B.C., and JULKUNEN, I. (1992). Interferon-induced Mx proteins form oligomers and contain a putative leucine zipper. J. Biol. Chem. 267, 25898-25907.
7. SCHUMACHER, B., and STAEHELI, P. (1998). Domains mediating intramolecular folding and oligomerization of MxA GTPase. J. Biol. Chem. 273, 28365-28370.
8. STAEHELI, P., HALLER, O., BOLL, W., LINDENMANN, J., and WEISSMANN, C. (1986). Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell 44, 147-158.
9. JIN, H.-K., YOSHIMATSU, K., TAKADA, A., OGINO, M., ASANO, A., ARIKAWA, J., and WATANABE, T. (2001). Mouse Mx2 protein inhibits hantavirus but not influenza virus replication. Arch. Virol. 146, 41-49.
10. MEIER, E., KUNZ, G., HALLER, O., and ARNHEITER, H. (1990). Activity of rat Mx proteins against a rhabdovirus. J. Virol. 64, 6263-6269.
11. ZÜRCHER, T., PAVLOVIC, J., and STAEHELI, P. (1992). Mouse Mx2 protein inhibits vesicular stomatitis virus but not influenza virus. Virology 187, 796-800.
12. PAVLOVIC, J., ZÜRCHER, T., HALLER, O., and STAEHELI, P. (1990). Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J. Virol. 64, 3370-3375.
13. KING, M.C., RAPOSO, G., and LEMMON, M.A. (2004). Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. Proc. Natl. Acad. Sci. USA 101, 8957-8962.
14. HORISBERGER, M.A., and GUNST, M.C. (1991). Interferon-induced proteins: identification of Mx proteins in various mammalian species. Virology 180, 185-190.
15. JENSEN, V., and ROBERTSEN, B. (2000). Cloning of an Mx cDNA from Atlantic halibut (Hippoglossus hippoglossus) and characterization of Mx mRNA expression in response to double-stranded RNA or infectious pancreatic necrosis virus. J. Interferon Cytokine Res. 20, 701-710.
16. TROBRIDGE, G.D., CHIOU, P.P., and LEONG, J.A. (1997). Cloning of the rainbow trout (Oncorhynchus mykiss) Mx2 and Mx3 cDNAs and characterization of trout Mx protein expression in salmon cells. J. Virol. 71, 5304-5311.
17. CHESTERS, P.M., STEELE, M., PUREWAL, A., and EDINGTON, N. (1997). Nucleotide sequence of equine MxA cDNA. DNA Sequence 7, 239-242.
18. ELLINWOOD, N.M., McCUE, J.M., GORDY, P.W., and BOWEN, R.A. (1998). Cloning and characterization of cDNAs for a bovine (Bos taurus) Mx protein. J. Interferon Cytokine Res. 18, 745-755.
19. KO, J.-H., JIN, H.-K., ASANO, A., TAKADA, A., NINOMIYA, A., KIDA, H., HOKIYAMA, H., OHARA, M., TSUZUKI, M., NISHIBORI, M., MIZUTANI, M., and WATANABE, T. (2002). Polymorphisms and the differential antiviral activity of the chicken Mx gene. Genome Res. 12, 527-530.
20. MÜLLER, M., WINNACKER, E.L., and BREM, G. (1992). Molecular cloning of porcine Mx cDNAs: new members of a family of interferon-inducible proteins with homology to GTP-binding proteins. J. Interferon Res. 12, 119-129.
21. ASANO, A., KO, J.-H., MOROZUMI, T., HAMASIMA, N., and WATANABE, T. (2002). Polymorphisms and the antiviral property of porcine Mx1 protein. J. Vet. Med. Sci. 64, 1085-1089.
22. KO, J.-H., ASANO, A., KON, Y., WATANABE, T., and AGUI, T. (2004). Characterization of the chicken PKR: polymorphism of the gene and antiviral activity against vesicular stomatitis virus. Jpn. J. Vet. Res. 51, 123-133.
23. JIN, H.-K., YAMASHITA, T., OCHIAI, K., HALLER, O., and WATANABE, T. (1998). Characterization and expression of the Mx1 gene in wild mouse species. Biochem. Genet. 36, 311-322.
24. JIN, H.-K., TAKADA, A., KON, Y., HALLER, O., and WATANABE, T. (1999). Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. J. Virol. 73, 4925-4930.
25. STAEHELI, P., GROB, R., MEIER, E., SUTCLIFFE, J.G., and HALLER, O. (1988). Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol. Cell. Biol. 8, 4518-4523.
26. STAEHELI, P., and SUTCLIFFE, J.G. (1988). Identification of a second interferon-regulated murine Mx gene. Mol. Cell. Biol. 8, 4524-4528.
27. ASANO, A., JIN, H.-K., and WATANABE, T. (2003). Mouse Mx2 gene: organization, mRNA expression and the role of the interferon-response promoter in its regulation. Gene 306, 105-113.
28. ZÜRCHER, T., PAVLOVIC, J., and STAEHELI, P. (1992). Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus. J. Virol. 66, 5059-5066.