Cataracts in experimentally diabetic mouse: Morphological and apoptotic changes

Diabetes, Obesity and Metabolism

Volumn 7, Issue 2, 2005, Pages 200-204

  Hegde, K R ^a   Varma, Shambhu D ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular changes; Diabetic cataract; Mouse lens; Ultra structure

Indexed keywords

ALDEHYDE REDUCTASE; ANTIOXIDANT; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; CATARACT; CATARACTOGENESIS; CELL ELONGATION; CELL MATURATION; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORNEA CELL; CORNEA EPITHELIUM; DIABETES MELLITUS; ELECTRON MICROSCOPY; ENZYME DEFECT; EPITHELIUM CELL; EXPERIMENTAL DIABETES MELLITUS; HISTOLOGY; ISOLATED ORGAN; LENS; MOUSE; NONHUMAN; STREPTOZOCIN DIABETES;

EID: 14844342811     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2004.00368.x     Document Type: Article

References (16)

1. Kahn HA, Leibowitz HM, Ganley JP et al. The Framingham Eye study I. Outline and major prevalence finding. Am J Epidemiol 1977; 106: 17-32.
2. Van Heyningen R. Formation of polyols by the lens of the rat with sugar cataracts. Nature 1959; 164: 194-196.
3. Varma SD, Kinoshita JH. Inhibition of lens aldose reductase by flavonoids-their possible role in the prevention of diabetic cataract. Biochem Pharmacol 1976; 25: 2505.
4. El-Aguizy HK, Richards RD, Varma SD. Sugar cataracts in mongolian gerbil (Meriones unguiculatus). Exp Eye Res 1983; 36: 839-844.
5. Varma SD, Kinoshita JH. Sorbitol pathway in diabetic and galactosemic rat lenses. Biochim Biophys Acta 1974; 338: 632-640.
6. Kinoshita JH. Mechanisms initiating cataract formation. Invest Ophthalmol Vis Sci 1974; 13: 713-724.
7. Varma SD, Kinoshita JH. The absence of cataracts in mice with congenital hyperglycemia. Exp Eye Res 1974; 19: 577-582.
8. Vrensen GF, Graw J, De Wolf A. Nuclear breakdown during terminal differentiation of primary lens fibres in mice: a transmission electron microscopy study. Exp Eye Res 1991; 52 (6): 647-659.
9. Kuwabara T, Imaizumi M. Denucleation process of the lens. Invest Ophthalmol Vis Sci 1974; 13 (12): 973-981.
10. Hegde KR, Henein MG, Varma SD. Establishment of the mouse as a model animal for the study of diabetic cataracts. Ophthalmic Res 2003; 35: 12-18.
11. Cerami A, Vlassara H, Brownlee M. Protein glycosylation and the pathogenesis of atherosclerosis. Metabolism 1985; 34: 37-44.
12. Monnier VM, Stevens VJ, Cerami A. Nonenzymatic glycosylation, sulfhydryl oxidation and aggregation of lens proteins in experimental sugar cataracts. J Exp Med 1979; 50: 1098-1107.
13. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40: 405-412.
14. Wolf SP, Crabbe MJC, Thornalley PJ. The auto-oxidation of glyceraldehydes and other simple monosaccharides. Experientia 1984; 40: 244-246.
15. Hegde KR, Henein MG, Varma SD. Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. Diabetes Obes Metab 2003; 5: 113-119.
16. Hegde KR, Varma SD, Morphogenotic and apoptotic changes in diabetic cataract. Prevention by pyruvate. Mol Cell Biochem 2004 (in press).