Establishment of the mouse as a model animal for the study of diabetic cataracts

Ophthalmic Research

Volumn 35, Issue 1, 2003, Pages 12-18

  Hegde, K R ^a   Henein, M G ^a   Varma, Shambhu D ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Cataract; Diabetes; Lens morphology

Indexed keywords

ALDEHYDE REDUCTASE; GLUCOSE; STREPTOZOCIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; DISEASE COURSE; ENUCLEATION; ENZYME ACTIVITY; EPITHELIUM CELL; EYE REFRACTION; FLUID INTAKE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; LENS CAPSULE; MOUSE; NONHUMAN; OPHTHALMOSCOPY; PATHOGENESIS; PHOTOGRAPHY; PRIORITY JOURNAL; SLIT LAMP; STREPTOZOCIN DIABETES; URINARY EXCRETION;

ANIMALS; BLOOD GLUCOSE; CATARACT; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; LENS, CRYSTALLINE; MICE;

EID: 0037259182     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068193     Document Type: Article

References (30)

1. Anthonisen H: The frequency of diabetic cataract and diabetic glaucoma as compared to the frequency of diabetes in the general population of Denmark. Acta Ophthalmol (Copenh) 1936; 14:150-158.
2. Caird IF, Hutchinson M, Pirie A: Cataract extraction and diabetes. Br J Ophthalmol 1964; 49:466-471.
3. Hiller R, Kahn H: Senile cataract extraction and diabetes. Br J Ophthalmol 1976;60:282-286.
4. Kirby DB: Cataract and diabetes. Arch Oph-thalmol 1933;9:966-973.
5. Marquandt VR, Kirschbaum H: Incidence and significance of diabetes mellitus among patients with senile cataracts. Klin Monatsbl Au-genheilkd 1971;159:769-773.
6. Towns CD, Casey E: Cataract surgery in diabetic patients. South Med J 1955;48:844-846.
7. Van Heyningen R: Formaton of polyols by the lens of the rat with sugar cataracts. Nature 1959;164:194-196.
8. Kuck JF: The formation of fructose in the ocular lens. Arch Ophthalmol 1961;65:100-106.
9. Varma SD, Kinoshita JH: Sorbitol pathway in diabetic and galactosemic rat lenses. Biochim Biophys Acta 1974;338:632-640.
10. Kinoshita JH: Mechanisms initiating cataract formation. Invest Ophthalmol Vis Sci 1974;13: 713-724.
11. Varma SD, Kinoshita JH: Inhibition of lens aldose reductase by flavonoids - Their possible role in the prevention of diabetic cataract. Biochem Pharmacol 1976;25:2505-2513.
12. Varma SD, Mikuni I, Kinoshita JH: Flavon-oids as inhibitors of lens aldose reductase. Science 1975;188:1215-1216.
13. Varma SD, Mizuno A, Kinoshita JH: Diabetic cataracts and flavonoids. Science 1977;195: 205-206.
14. Chylack L, Henriques HF, Cheng HM, Tung WH: Efficacy of alrestatin, an aldose reductase inhibitor, in human diabetic and nondiabetic lenses. Ophthalmol 1979;86:1579-1585.
15. Stevens VJ, Rouzer CA, Monnier VM, Cerami A: Diabetic cataract formation and potential role of glycosylation of lens proteins. Proc Natl Acad Sci USA 1978;75:2918-2922.
16. Monnier VM, Stevens VJ, Cerami A: Nonenzy-matic glycosylation, sulfhydryl oxidation and aggregation of lens proteins in experimental sugar cataracts. J Exp Med 1979;50:1098-1107.
17. Swamy MS, Abraham EC: Lens protein composition, glycation and high molecular weight aggregation in ageing rats. Invest Ophthalmol Vis Sci 1987;28:1693-1701.
18. Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405-412.
19. Kilic F, Trevithick JR: Modelling cortical cata-ractogenesis. XXIX. Calpain proteolysis of lens fodrin in cataract. Biochem Mol Biol Int 1998; 45:963-978.
20. Bantseev VL, Herbert KL, Trevithick JR, Si-vak JG: Mitochondria of rat lenses: Distribution near and at the sutures. Curr Eye Res 1999;19:506-516.
21. Wang L, Christensen BN, Bhatnagar A, Srivas-tava SK: Role of calcium-dependent pro-tease(s) in globulization of isolated rat lens cortical fiber cells. Invest Ophthalmol Vis Sci 2001;42:194-199.
22. Varma SD, Kinoshita JH: The absence of cataracts in mice with congenital hyperglycemia. Exp Eye Res 1974;19:577-582.
23. Like AA, Rossini AA: Streptozotocin induced pancreatic insulitis: New model of diabetes mellitus. Science 1976;193:415-417.
24. Like AA, Appel MC, Williams RM, Rossini A: Streptozotocin induced pancreatic insulitis in mice: Morphologic and physiologic studies. Lab Invest 1978;38:470-486.
25. Hockwin O, Dragomirescu V, Shibata T, Laser H, Wegener A: Long-term follow-up examination of experimental cataracts in rats by Scheimpflug photography and densitometry. Graefes Arch Clin Exp Ophthalmol 1984;222: 20-25.
26. Chaikoff I, Lachman G: Occurrence of cataract in experimental pancreatic diabetes. Proc Soc Exp Biol Med 1933;31:237-241.
27. Foglia V, Cramer F: Experimental production of diabetic cataract in the rat. Proc Soc Exp Biol Med 1944;55:218-219.
28. Isselbacher KJ: Galactosemia; in Stanbury JB, Wyngaarden JB, Fredrickson DS (eds): The Metabolic Basis of Inherited Disease. New York, McGraw-Hill, 1966, pp 178-188.
29. Patterson JW: Effect of lowered blood sugar on development of diabetic cataracts. Am J Physi-ol 1953;172:77-82.
30. Bhuyan KC, Bhuyan DK, Podos SM: Evidence of increased lipid peroxidation in cataracts. IRCS Med Sci 1981;9:126-127.