Beyond structural reductionism in biology

Complexity

Volumn 10, Issue 3, 2005, Pages 18-21

  Petty, Aaron R ^b   Petty, Howard R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 14844314831     PISSN: 10762787     EISSN: None     Source Type: Journal    
DOI: 10.1002/cplx.20064     Document Type: Review

References (20)

1. Bélair, J.; Glass, L.; an der Heiden, U.; Milton J. Dynamical Disease: Mathematical Analysis of Human Illness, AIP Press: Woodbury, NY, 1995.
2. Petty, H.R. Neutrophil oscillations: temporal and spatiotemporal aspects of cell behavior. Immunologic Res 2001, 23, 125-134.
3. Petty, H.R. Applications of high-speed microscopy in biomedical research. Optics Photonics News 2004, January, 34-40.
4. Petty, H.R.; Worth, R.G.; Kindzelskii, A.L. Imaging sustained dissipative patterns in the metabolism of individual living cells. Phys Rev Lett 2000, 84, 2754-2757.
5. Petty, H.R.; Kindzelskii, A.L. High-speed imaging of sustained metabolic target patterns in living neutrophils during adherence. J Phys Chem B 2000, 104, 10952-10955.
6. Petty, H.R.; Kindzelskii, A.L. Dissipative metabolic patterns respond during neutrophil transmembrane signaling. Proc Natl Acad Sci USA 2001, 98, 3145-3149.
7. Kindzelskii, A.L.; Petty, H.R. Apparent role of traveling metabolic waves in periodic oxidant release by living cells. Proc Natl Acad Sci, USA 2002, 99, 9207-9212.
8. Olsen, L.F.; Kummer, U.; Kindzelskii, A.L.; Petty, H.R. A model of the oscillatory metabolism of activated neutrophils. Biophys J 2003, 84, 69-81.
9. Kindzelskii, A.L.; Sitrin, R.G.; Petty, H.R. Cutting edge: Optical microspectrophotometry supports the existence of gel phase lipid rafts at the lamellipodium of neutrophils: apparent role in calcium signaling. J Immunol 2004, 172, 4681-4685.
10. Kindzelskii, A.L.; Petty, H.R. Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes. Eur Biophys J 2004, 33, 291-299.
11. Albrecht, E.; Kindzelskii, A.L.; Petty, H.R. Signal processing times in neutrophil activation: Dependence on ligand concentration and relative metabolic phase. Biophys Chem 2003, 106, 211-219.
12. Rosenspire, A.J.; Kindzelskii, A.L.; Petty, H.R. Cutting edge: Febrile temperatures dramatically enhance local oxidant release by adherent neutrophils in response to lipopolysaccharide. J Immunol 2002, 169, 5396-5400.
13. Kindzelskii, A.L.; Huang, J.-B.; Chaiworapongsa, T.; Kim, Y.M.; Romero, R.; Petty, H.R. Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism and oxidant release of maternal neutrophils. J Clin Invest 2002, 110, 1801-1811.
14. Kindzelskii, A.L.; Ueki, T.; Michibata, H.; Chaiworapongsa, T.; Romero, R.; Petty H.R. 6-Phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase form complexes in human neutrophils and traffic to the centrosome in pregnant, but not non-pregnant, women. J Immunol 2004, 172, 6373-6381.
15. Worth, R.G.; Kim, M.-K.; Kindzelskii, A.L.; Petty, H.R.; Schreiber A.D. Signal sequence within FcγRIIA controls calcium wave propagation patterns: Apparent role in phagolysosome fusion. Proc Natl Acad Sci USA 2003, 100, 4533-4538.
16. Kindzelskii A.L.; Petty H.R. Intracellular calcium waves accompany neutrophil polarization, fMet-Leu-Phe stimulation and phagocytosis: A high-speed microscopy study. J Immunol 2003, 170, 64-72.
17. Petty, H.R. Dynamic chemical instabilities in living cells may provide a novel route in drug development. Chem BioChem 2004, 5, 1359-1364.
18. Rosenspire, A.J.; Kindzelskii, A.L.; Petty H.R. Pulsed DC electric fields couple to natural NAD(P)H oscillations in HT1080 fibrosarcoma cells. J Cell Sci 2001, 114, 1515-1526.
19. Kindzelskii, A.L.; Petty, H.R. Extremely low frequency pulsed DC electric fields promote neutrophil extension, metabolic resonance and DNA damage when phase-matched with metabolic oscillators. Biochim Biophys Acta 2000, 1495, 90-111.
20. Huang, J.-B.; Kindzelskii, A.L.; Clark, A.J.; Petty H.R. Identification of channels promoting calcium spikes and waves in HT1080 tumor cells: Their apparent roles in cell motility and invasion. Cancer Res 2004, 64, 2482-2489.