Sphincter preservation with chemoradiation in Anal canal carcinoma: Abdominoperineal resection in selected cases?

Diseases of the Colon and Rectum

Volumn 41, Issue 4, 1998, Pages 441-450

  Grabenbauer, Gerhard G ^a   Matzel, Klaus E ^a   Schneider, Ignaz H F ^a   Meyer, Martin ^a   Wittekind, Christian ^a   Matsche, Birgit ^a   Hohenberger, Werner ^a   Sauer, Rolf ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Anal canal cancer; Chemotherapy; Combination therapy; MIB1; Ploidy; Prognostic factors; Radiation

Indexed keywords

FLUOROURACIL; MITOMYCIN;

ADULT; AGED; ANUS CARCINOMA; ANUS SPHINCTER; ARTICLE; BONE MARROW TOXICITY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; DERMATITIS; DIARRHEA; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; PLOIDY; POSTOPERATIVE COMPLICATION; PROGNOSIS; RECTUM ABDOMINOPERINEAL RESECTION; RISK FACTOR; TREATMENT FAILURE; TREATMENT INDICATION; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COLOSTOMY; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; KI-67 ANTIGEN; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; PROLIFERATING CELL NUCLEAR ANTIGEN; RADIOTHERAPY; SALVAGE THERAPY; SURVIVAL RATE;

EID: 0031894788     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02235757     Document Type: Article

References (40)

1. Allal A, Kurtz JM, Pipard G, et al. Radiochemotherapy versus radiotherapy alone for anal cancer: a retrospective comparison. Int J Radiat Oncol Biol Phys 1993;27: 59-66.
2. Cantril ST, Green JP, Schall GL, Schaupp WC. Primary radiation therapy in the treatment of anal carcinoma. Int J Radiat Oncol Biol Phys 1983;9:1271-8.
3. Eschwege F, Laser P, Chavy A, Wibault P, Kac J, Rougier Ph. Squamous cell carcinoma of the anal canal: treatment by external beam irradiation. Radiother Oncol 1985;3:145-50.
4. Schlienger M, Krzish C, Pene F, et al. Epidermoid carcinoma of the anal canal: treatment results and prognostic variables in a series of 242 cases. Int J Radiat Oncol Biol Phys 1989;17:1141-51.
5. Touboul E, Schlienger M, Buffat L, et al. Epidermoid carcinoma of the anal canal. Cancer 1994;73:1569-79.
6. Touboul E, Schlienger M, Buffat L, et al. Conservative versus nonconservative treatment of epidermoid carcinoma of the anal canal for tumors longer than or equal to 5 centimeters. Cancer 1995;75:786-93.
7. Wagner JP, Mahe MA, Romestaing P, et al. Radiation therapy in the conservative treatment of carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 1994;29: 17-23.
8. Cummings BJ. Anal cancer. Int J Radiat Oncol Biol Phys 1990;19:1309-15.
9. Cummings BJ, Keane TJ, O'Sullivan B, Wong, CS, Catton CN. Epidermoid canal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys 1991;21:1115-25.
10. Cummings BJ. Anal canal carcinoma. In: Hermanek P, Gospodarowicz MK, Henson DE, Hutter RV, Sobin LH, eds. Prognostic factors in cancer. Berlin: Springer-Verlag, 1995:81-7.
11. Flam MS, John M, Pajak T, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 1996;14:2527-39.
12. Grabenbauer GG, Schneider IH, Gall F, Sauer R. Epidermoid carcinoma of the anal canal: treatment by combined radiation and chemotherapy. Radiother Oncol 1993;27:59-62.
13. Grabenbauer GG, Panzer M, Hültenschmidt B, et al. Prognostische Faktoren nach simultaner Radiochemotherapie des Analkanalkarzinoms in einer multizentrischen Serie von 139 Patienten. Strahlenther Onkol 1994;170:391-9.
14. Schneider IH, Grabenbauer GG, Reck T, Köckerling F, Sauer R, Gall FP. Combined radiation and chemotherapy for epidermoid carcinoma of the anal canal. Int J Colorectal Dis 1992;7:192-6.
15. Martenson JA, Lipsitz SR, Lefkopoulou M, et al. Results of combined modality therapy for patients with anal cancer. Cancer 1995;76:1731-6.
16. Myerson RJ, Shapiro SJ, Lacey D, et al. Carcinoma of the anal canal. Am J Clin Oncol 1995;18:32-9.
17. Nigro ND, Vaitkevicius VK, Considine B Jr. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 1974;17:354-6.
18. Sischy B. The use of radiation therapy combined with chemotherapy in the management of squamous cell carcinoma of the anus. Int J Radiat Oncol Biol Phys 1985;11:1587-93.
19. Sischy B, Doggett RL, Krall JM, et al. Definitive irradiation and chemotherapy for radiosensitisation in management of anal carcinoma: interim report on RTOG study no. 8314. J Natl Cancer Inst 1989;81:850-6.
20. UKCCCR Anal Canal Cancer Trial Working Party. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 1996;348: 1049-54.
21. Hermanek P, Sobin LH, eds. UICC TNM classification of malignant tumors. 4th ed (2nd revision). Berlin: Springer-Verlag, 1992.
22. John MJ. Grading of chemoradiation toxicity. In: John MJ, Flam MS, Legha SS, et al., eds. Chemoradiation: an integrated approach to cancer treatment. Philadelphia: Lea & Fiebiger, 1993:601-6.
23. WHO. International classification of diseases for oncology. 2nd ed. Geneva, 1990.
24. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53: 457-81.
25. Cox DR. Regression models and life tableas. J R Stat Soc 1972;B34:187-202.
26. Papillon J, Montbaron JF, Gerard JP, Chassard JL, Ardiet JM, Touraine-Romestaing P. Role of combined radiation and chemotherapy: the Lyon experience. In: Sauer R, ed. Interventional radiation therapy. Berlin: Springer-Verlag, 1991.
27. Pipard, G. Combined therapy of anal canal cancer: a report on external irradiation with or without chemotherapy followed by interstitial Ir-192. In: Sauer R, ed. Interventional radiation therapy. Berlin: Springer-Verlag, 1991.
28. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III-randomized trial of the European Organisation for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997;15:2040-9.
29. Ng YK, Pigneux J, Auvray H, Brunet R, Thomas L, Denepoux R. Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982. Int J Radiat Oncol Biol Phys 1988;14: 253-9.
30. Papillon J, Montbarbon JF. Epidermoid carcinoma of the anal canal: a series of 276 cases. Dis Colon Rectum 1987;30:324-33.
31. Boman BM, Moertel CG, O'Connel MJ, et al. Carcinoma of the anal canal - a clinical and pathologic study of 188 cases. Cancer 1984;54:114-25.
32. Frost DB, Richards PC, Montague ED, Giacco GG, Martin RG. Epidermoid cancer of the anorectum. Cancer 1984;53:1285-93.
33. Pintor MP, Northover JM, Nicolls RJ. Squamous cell carcinoma of the anus 1948-1984. Br J Surg 1989;76: 806-10.
34. Shephard NA, Scholefield JH, Love SB, England J, Northover JM. Prognostic factors in anal squamous cell carcinoma: a multivariate analysis of clinical flow cytometric and pathologic factors in 235 cases. Histopathology 1990;16:545-55.
35. Panzer M, Sutter T, Wendt T, Jauch KW. Radiochemotherapie mit und ohne Radikaloperation bei Analkarzinom: Großhaderner Langzeitergebnisse. Tumordiagn Ther 1993;14:167-74.
36. Goldman S, Svensson C, Bronnergard M, Glimelius B, Wallin G. Prognostic significance of serum concentration of squamous cell carcinoma antigen in anal epidermoid carcinoma. Int J Colorectal Dis 1993;8: 98-102.
37. Störkel S, Reichert T, Reiffen KA, Wagner W. EGFR and PCNA expression in oral squamous cell carcinoma - a valuable tool in estimating the patient prognosis. Eur J Cancer 1993;29B:273-7.
38. Hake R, Echel E, Pritzbuer E, Volling P, Thiele J. Wertigkeit monoklonaler Antikörper (PC10, MIB1, p53 und Leu M1) ffür die Abschätzung der Prognose von Patienten mit Plattenepithelkarzinomen des Larynx nach Laserresektion. Pathologe 1995;16:197-203.
39. Günzl HJ, Horn H, Schnücke R, Donath K. Prognostic value of PCNA and cytokeratins for radiation therapy of oral squamous cell carcinoma. Eur J Cancer 1993;29B: 141-5.
40. Munck-Wikland E, Fernber J, Kuylenstierna R, Lindholm J, Auer G. PCNA expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancer. Eur J Cancer 1993;29B:75-9.