Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose concentrations and sedation in dogs treated with dexmedetomidine

American Journal of Veterinary Research

Volumn 66, Issue 2, 2005, Pages 260-265

  Raekallio, Marja R ^a   Kuusela, Erja K ^a   Lehtinen, Milla E ^a   Tykkyläinen, Marja K ^a   Huttunen, Pirkko ^a,b   Westerholm, Fia C ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c ORION CORPORATION   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; DEXAMETHASONE; DEXMEDETOMIDINE; GLUCOSE; HORMONE; HYDROCORTISONE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BREATHING RATE; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; DOG; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; HEART RATE; HORMONE BLOOD LEVEL; HYDROCORTISONE BLOOD LEVEL; MALE; NONHUMAN; PHYSICAL STRESS; RANDOMIZATION; RECTUM TEMPERATURE; SEDATION; TREADMILL EXERCISE;

ANIMALS; BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEXAMETHASONE; DEXMEDETOMIDINE; DOGS; DRUG THERAPY, COMBINATION; EPINEPHRINE; FEMALE; GLUCOCORTICOIDS; HORMONES; HYDROCORTISONE; HYPNOTICS AND SEDATIVES; IMMUNOASSAY; MALE; NOREPINEPHRINE; PHYSICAL CONDITIONING, ANIMAL; RADIOIMMUNOASSAY; STRESS; VASOPRESSINS;

ANIMALIA; CANIS FAMILIARIS;

EID: 14844292573     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.260     Document Type: Article

References (19)

1. Raekallio M, Leino A, Vainio O, et al. Sympatho-adrenal activity and the clinical sedative effectiveness of detomidine in horses. Equine Vet J Suppl 1992;11:66-68.
2. Kock MD, Meert TF. Alpha-2-adrenoceptor agonists and stress-induced analgesia in rats: influence of stressors and methods of analysis. Pharmacol Biochem Behav 1997;58:109-117.
3. Raekallio M, Ansah OB, Kuusela E, et al. Some factors influencing the level of clinical sedation induced by medetomidine in rabbits. J Vet Pharmacol Ther 2002;25:39-42.
4. Flügge G. Effects of cortisol on brain alpha2-adrenoceptors: potential role in stress. Neurosci Biobehav Rev 1999;23:949-956.
5. Komesaroff PA, Funder JW. Differential glucocorticoid effects on catecholamine responses to stress. Am J Physiol 1994;266:E118-E128.
6. Malarkey WB, Lipkus IM, Cacioppo JT. The dissociation of catecholamine and hypothalamic-pituitary-adrenal responses to daily stressors using dexamethasone. J Clin Endocrinol Metab 1995;80:2458-2463.
7. Ambrisko TD, Hikasa Y. Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs. Can J Vet Res 2002;66:42-49.
8. Benson GJ, Grubb TL, Neff-Davis C, et al. Perioperative stress response in the dog: effect of pre-emptive administration of medetomidine. Vet Surg 2000;29:85-91.
9. Väisänen M, Raekallio M, Kuusela E, et al. Evaluation of the perioperative stress response in canine patients administered medetomidine or acepromazine as part of the preanesthetic medication. Am J Vet Res 2002;63:969-975.
10. Ko JC, Mandsager RE, Lange DN, et al. Cardiorespiratory responses and plasma cortisol concentrations in dogs treated with medetomidine before undergoing ovariohysterectomy. J Am Vet Med Assoc 2000;217:509-514.
11. Hubbell JA, Hinchcliff KW, Schmall LM, et al. Cardiorespiratory and metabolic effects of xylazine, detomidine, and a combination of xylazine and acepromazine administered after exercise in horses. Am J Vet Res 1999;60:1271-1279.
12. Alexander SL, Irvine CH. The effect of the alpha-2-adrenergic agonist, clonidine, on secretion patterns and rates of adrenocorticotropic hormone and its secretagogues in the horse. J Neuroendocrinol 2000; 12:874-880.
13. McKeever KH, Hinchcliff KW, Cooley JL, et al. Furosemide magnifies the exercise-induced elevation of plasma vasopressin concentration in horses. Res Vet Sci 1993;55:151-155.
14. el-Sayed MS, Davies B, Morgan DB. Vasopressin and plasma volume response to submaximal and maximal exercise in man. J Sports Med Phys Fitness 1990;30:420-425.
15. Wittert GA, Stewart DE, Graves MP, et al. Plasma corticotrophin releasing factor and vasopressin responses to exercise in normal man. Clin Endocrinol (Oxf) 1991;35:311-317.
16. Koepke JP, Light KC, Obrist PA, et al. Vasopressin and urine flow rate responses to stress in conscious dogs. Am J Physiol 1984; 247:F213-F218.
17. Burton SA, Lemke KA, Ihle SL, et al. Effects of medetomidine on serum insulin and plasma glucose concentrations in clinically normal dogs. Am J Vet Res 1997;58:1440-1442.
18. Huang C, Banerjee K, Sochett E, et al. Hypoglycemia associated with clonidine testing for growth hormone deficiency. J Pediatr 2001;139:323-324.
19. Cullen LK. Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J 1996;152:519-535.