Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 817, Issue 2, 2005, Pages 287-296

  Xu, Yang ^a   Du, Lihong ^a   Soli, Eric D ^a   Braun, Matthew P ^a   Dean, Dennis C ^a   Musson, Donald G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

KDR kinase inhibitor; LC MS MS; N Oxide metabolite; Oasis MCX solid phase 96 well extraction plate

Indexed keywords

ACETONITRILE; AMMONIUM COMPOUNDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS;

KDR KINASE INHIBITORS; LOWER LIMITS OF QUANTITATION (LLOQ); MULTIPLE REACTION MONITORING (MRM); SOLID-PHASE EXTRACTION (SPE);

ENZYME INHIBITION;

3 [5 (4 METHANESULFONYLPIPERAZIN 1 YLMETHYL) 1H INDOL 2 YL] 1H QUINOLIN 2 ONE; ACETONITRILE; AMMONIUM ACETATE; OXIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DETERMINATION; FLOW RATE; FREEZE THAWING; HUMAN; LIQUID CHROMATOGRAPHY; PH MEASUREMENT; PLASMA; PRIORITY JOURNAL; ROOM TEMPERATURE; SOLID PHASE EXTRACTION; STATISTICAL SIGNIFICANCE; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MASS SPECTROMETRY; OXIDES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 14744302792     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.12.019     Document Type: Article

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