메뉴 건너뛰기




Volumn 12, Issue 2, 2005, Pages 129-134

New developments in iron chelators

Author keywords

Chelation; Iron; Thalassemia

Indexed keywords

40SD02; DEFERASIROX; DEFERIPRONE; DEFERITRIN; DEFEROXAMINE; IRON CHELATING AGENT; PYRIDOXAL ISONICOTINOYLHYDRAZONE; UNCLASSIFIED DRUG;

EID: 14644438604     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.moh.0000152631.63469.07     Document Type: Review
Times cited : (29)

References (50)
  • 1
    • 0345620381 scopus 로고
    • Chelating agents in the diagnosis and treatment of iron overload in thalassemia
    • Smith RS. Chelating agents in the diagnosis and treatment of iron overload in thalassemia. Ann N Y Acad Sci 1964; 119:776-788.
    • (1964) Ann N Y Acad Sci , vol.119 , pp. 776-788
    • Smith, R.S.1
  • 2
    • 0014440997 scopus 로고
    • Clinical usefulness of iron chelating agents
    • Waxman HS, Brown EB. Clinical usefulness of iron chelating agents. Prog Hematol 1969; 6:338-373.
    • (1969) Prog Hematol , vol.6 , pp. 338-373
    • Waxman, H.S.1    Brown, E.B.2
  • 3
    • 0015947937 scopus 로고
    • Long-term chelation therapy in thalassaemia major: Effect on liver iron concentration, liver histology, and clinical progress
    • Barry M, Flynn M, Letsky EA, Risdon RA. Long-term chelation therapy in thalassaemia major: Effect on liver iron concentration, liver histology, and clinical progress. BMJ 1974; 2:16-20.
    • (1974) BMJ , vol.2 , pp. 16-20
    • Barry, M.1    Flynn, M.2    Letsky, E.A.3    Risdon, R.A.4
  • 4
    • 0017622851 scopus 로고
    • Continuous subcutaneous administration of deferoxamine in patients with iron overload
    • Propper RD, Cooper B, Rufo RR, et al. Continuous subcutaneous administration of deferoxamine in patients with iron overload. N Engl J Med 1977; 297:418-423.
    • (1977) N Engl J Med , vol.297 , pp. 418-423
    • Propper, R.D.1    Cooper, B.2    Rufo, R.R.3
  • 5
    • 20844460608 scopus 로고    scopus 로고
    • Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine
    • Borgna-Pignatti C, Rugolotto S, De Stefano P, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 2004; 89:1187-1193. A comprehensive review of nearly 1700 patients treated at seven Italian teaching hospitals. There is a review of survival and complication-free survival based on birth cohort demonstrating progressive improvement in patients with thalassemia.
    • (2004) Haematologica , vol.89 , pp. 1187-1193
    • Borgna-Pignatti, C.1    Rugolotto, S.2    De Stefano, P.3
  • 8
    • 0141705304 scopus 로고    scopus 로고
    • Labile plasma iron in iron overload; Redox activity and susceptibility to chelation
    • Esposito BP, Breuer W, Sirankapracha P, et al. Labile plasma iron in iron overload; Redox activity and susceptibility to chelation. Blood 2003; 102:2670-2677. This paper reviews the information known regarding NTBI and furthers the evaluation by studying labile plasma iron and directly chelatable iron as measures that may be helpful in vivo in assessing chelation efficacy.
    • (2003) Blood , vol.102 , pp. 2670-2677
    • Esposito, B.P.1    Breuer, W.2    Sirankapracha, P.3
  • 9
    • 4444274916 scopus 로고    scopus 로고
    • Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator
    • Pootrakul P, Breuer W, Sametband M, et al. Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator. Blood 2004; 104:1504-1510. This paper evaluated labile plasma iron and directly chelatable iron in patients receiving deferiprone.
    • (2004) Blood , vol.104 , pp. 1504-1510
    • Pootrakul, P.1    Breuer, W.2    Sametband, M.3
  • 10
    • 0022111669 scopus 로고
    • Heart cells in culture: A model of myocardial iron overload and chelation
    • Link G, Pinson A, Hershko C. Heart cells in culture: a model of myocardial iron overload and chelation. J Lab Clin Med 1985; 106:147-153.
    • (1985) J Lab Clin Med , vol.106 , pp. 147-153
    • Link, G.1    Pinson, A.2    Hershko, C.3
  • 11
    • 0038133426 scopus 로고    scopus 로고
    • Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation
    • Miskin H, Yaniv I, Berant M, et al. Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation. Eur J Haematol 2003; 70:398-403. An important, possibly alternative, chelation strategy is presented and evaluated retrospectively in a small population of noncompliant patients and may suggest a viable approach to patients who, despite 'requiring' 24/7 chelation for cardiac complications, are unable to comply and continue to deteriorate.
    • (2003) Eur J Haematol , vol.70 , pp. 398-403
    • Miskin, H.1    Yaniv, I.2    Berant, M.3
  • 12
    • 2942616383 scopus 로고    scopus 로고
    • Purging iron from the heart
    • Hershko C, Cappellin MD, Galanello R, et al. Purging iron from the heart. Br J Haematol 2004; 125:545-551. Comprehensive review of myocardial siderosis and evidence for deferiprone and deferoxamine in cardiac siderosis.
    • (2004) Br J Haematol , vol.125 , pp. 545-551
    • Hershko, C.1    Cappellin, M.D.2    Galanello, R.3
  • 13
    • 0034651775 scopus 로고    scopus 로고
    • Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia
    • Davis BA, Porter JB. Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia. Blood 2000; 95:1229-1236.
    • (2000) Blood , vol.95 , pp. 1229-1236
    • Davis, B.A.1    Porter, J.B.2
  • 15
    • 0033536288 scopus 로고    scopus 로고
    • The beta-thalassemias
    • Olivieri NF. The beta-thalassemias. N Engl J Med 1999; 341:99-109.
    • (1999) N Engl J Med , vol.341 , pp. 99-109
    • Olivieri, N.F.1
  • 16
    • 0025878026 scopus 로고
    • Prolonged survival in patients with beta-thalassemia major treated with deferoxamine
    • Ehlers KH, Giardina PJ, Lesser ML, et al. Prolonged survival in patients with beta-thalassemia major treated with deferoxamine. J Pediatr 1991; 118:540-545.
    • (1991) J Pediatr , vol.118 , pp. 540-545
    • Ehlers, K.H.1    Giardina, P.J.2    Lesser, M.L.3
  • 17
    • 3042758517 scopus 로고    scopus 로고
    • Complications of beta-thalassemia major in North America
    • Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR. Complications of beta-thalassemia major in North America. Blood 2004; 104:34-39. This is a comprehensive, albeit on time, registry data collection and review of 342 North American patients with thalassemia.
    • (2004) Blood , vol.104 , pp. 34-39
    • Cunningham, M.J.1    Macklin, E.A.2    Neufeld, E.J.3    Cohen, A.R.4
  • 18
    • 0042810743 scopus 로고    scopus 로고
    • Results of long term iron chelation treatment with deferoxamine
    • Davis BA, Porter JB. Results of long term iron chelation treatment with deferoxamine. Adv Exp Med Biol 2002; 509:91-125.
    • (2002) Adv Exp Med Biol , vol.509 , pp. 91-125
    • Davis, B.A.1    Porter, J.B.2
  • 19
    • 0036431540 scopus 로고    scopus 로고
    • Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia
    • Porter JB, Davis BA. Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia. Best Pract Res Clin Haematol 2002; 15:329-368.
    • (2002) Best Pract Res Clin Haematol , vol.15 , pp. 329-368
    • Porter, J.B.1    Davis, B.A.2
  • 20
    • 0020465049 scopus 로고
    • Magnetic-susceptibility measurement of human iron stores
    • Brittenham GM, Farrell DE, Harris JW, et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982; 307:1671-1675.
    • (1982) N Engl J Med , vol.307 , pp. 1671-1675
    • Brittenham, G.M.1    Farrell, D.E.2    Harris, J.W.3
  • 21
    • 11244355277 scopus 로고    scopus 로고
    • Non-invasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    • St Pierre TG, Clark PR, Chua-anusorn W, et al. Non-invasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005; 105:855-861. Report of data on 105 subjects evaluating the correlation between liver iron content by biopsy and R2 MRI. Reviews the methodology and technology.
    • (2005) Blood , vol.105 , pp. 855-861
    • St Pierre, T.G.1    Clark, P.R.2    Chua-anusorn, W.3
  • 22
    • 18044399191 scopus 로고    scopus 로고
    • Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
    • Anderson LJ, Holden S, Davis B, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001; 22:2171-2179.
    • (2001) Eur Heart J , vol.22 , pp. 2171-2179
    • Anderson, L.J.1    Holden, S.2    Davis, B.3
  • 23
    • 7944230624 scopus 로고    scopus 로고
    • Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance
    • Anderson LJ, Westwood MA, Holden S, et al. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 2004; 127:348-355. Prospective study of seven patients placed on intravenous deferoxamine for iron-induced cardiac disease. The patients were noted to have statistically improved LVEF, liver iron, and cardiac iron as measured by T2* MRI. Cardiac iron was noted to decrease more slowly than liver iron.
    • (2004) Br J Haematol , vol.127 , pp. 348-355
    • Anderson, L.J.1    Westwood, M.A.2    Holden, S.3
  • 24
    • 0037431751 scopus 로고    scopus 로고
    • Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility
    • St Pierre TG. Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet 2003; 361:182-184.
    • (2003) Lancet , vol.361 , pp. 182-184
    • St Pierre, T.G.1
  • 25
    • 0037431751 scopus 로고    scopus 로고
    • Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility
    • Fischer R, Engelhardt R. Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet 2003; 361:182-183.
    • (2003) Lancet , vol.361 , pp. 182-183
    • Fischer, R.1    Engelhardt, R.2
  • 26
    • 0037431884 scopus 로고    scopus 로고
    • Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility
    • Brittenham GM, Nathan DG, Olivieri N, et al. Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet 2003; 361:183-184.
    • (2003) Lancet , vol.361 , pp. 183-184
    • Brittenham, G.M.1    Nathan, D.G.2    Olivieri, N.3
  • 27
    • 0037431883 scopus 로고    scopus 로고
    • Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility
    • Kontoghiorghes GJ, Kolnagou A. Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet 2003; 361:184.
    • (2003) Lancet , vol.361 , pp. 184
    • Kontoghiorghes, G.J.1    Kolnagou, A.2
  • 28
    • 14644442183 scopus 로고    scopus 로고
    • Non-invasive estimation of cardiac hemosiderosis by quantitated computed tomography
    • San Francisco. San Francisco, California: National Sickle Cell Disease Program
    • Cann CE, Quill L, Koerper M, Mentzer W. Non-invasive estimation of cardiac hemosiderosis by quantitated computed tomography. 23rd Annual Meeting, National Sickle Cell Disease Program, San Francisco. San Francisco, California: National Sickle Cell Disease Program; 1999.
    • (1999) 23rd Annual Meeting, National Sickle Cell Disease Program
    • Cann, C.E.1    Quill, L.2    Koerper, M.3    Mentzer, W.4
  • 29
    • 0019915682 scopus 로고
    • Noninvasive quantitation of liver iron in dogs with hemochromatosis using dual-energy CT scanning
    • Goldberg HI, Cann CE, Moss AA, et al. Noninvasive quantitation of liver iron in dogs with hemochromatosis using dual-energy CT scanning. Invest Radiol 1982; 17:375-380.
    • (1982) Invest Radiol , vol.17 , pp. 375-380
    • Goldberg, H.I.1    Cann, C.E.2    Moss, A.A.3
  • 30
    • 14644418314 scopus 로고
    • Dual energy CT for quantitating myocardial iron levels in haemochromatosis
    • American Heart Association Abstracts of the 54th Scientific Sessions
    • Lipton MJ, Cann CE, Goldberg HI, et al. Dual energy CT for quantitating myocardial iron levels in haemochromatosis. American Heart Association Abstracts of the 54th Scientific Sessions. Circulation 1981; 64:IV-221.
    • (1981) Circulation , vol.64
    • Lipton, M.J.1    Cann, C.E.2    Goldberg, H.I.3
  • 31
    • 3042746877 scopus 로고    scopus 로고
    • Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
    • Davis BA, O'Sullivan C, Jarritt PH, Porter JB. Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major. Blood 2004; 104:263-269. Review of 81 patients who had intensification of their chelation therapy based on decreasing cardiac ejection fraction. Demonstrates the importance of careful annual monitoring of cardiac function and the improved outcomes with aggressive early intervention.
    • (2004) Blood , vol.104 , pp. 263-269
    • Davis, B.A.1    O'Sullivan, C.2    Jarritt, P.H.3    Porter, J.B.4
  • 32
    • 0344392914 scopus 로고    scopus 로고
    • Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy
    • Yang T, Brittenham GM, Dong WQ, et al. Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy. J Lab Clin Med 2003; 142:332-340.
    • (2003) J Lab Clin Med , vol.142 , pp. 332-340
    • Yang, T.1    Brittenham, G.M.2    Dong, W.Q.3
  • 33
    • 3042842872 scopus 로고    scopus 로고
    • Study of intermittent intravenous deferrioxamine high-dose therapy in heavily iron-loaded children with beta-thalassemia major poorly compliant to subcutaneous injections
    • Wali YA, Taqi A, Deghaidi A. Study of intermittent intravenous deferrioxamine high-dose therapy in heavily iron-loaded children with beta-thalassemia major poorly compliant to subcutaneous injections. Pediatr Hematol Oncol 2004; 21:453-460. Presents prospective data on very aggressive chelation therapy requiring inpatient admissions frequently for short duration in patients who are noncompliant. This may offer an alternative for patients who are prescribed 24/7 chelation but are unable to comply.
    • (2004) Pediatr Hematol Oncol , vol.21 , pp. 453-460
    • Wali, Y.A.1    Taqi, A.2    Deghaidi, A.3
  • 34
    • 7044277330 scopus 로고    scopus 로고
    • A phase Ib study of safety, pharmacokinetics, acute tolerability, and efficacy of ascending single doses of 40SD02 (CHF 1540, GS 460) in iron-loaded patients
    • Harmatz P, Grady WB, Vichinsky E. A phase Ib study of safety, pharmacokinetics, acute tolerability, and efficacy of ascending single doses of 40SD02 (CHF 1540, GS 460) in iron-loaded patients. Blood 2003; 102:121a.
    • (2003) Blood , vol.102
    • Harmatz, P.1    Grady, W.B.2    Vichinsky, E.3
  • 35
    • 0037630378 scopus 로고    scopus 로고
    • Role of deferiprone in chelation therapy for transfusional iron overload
    • Hoffbrand AV, Cohen A, Hershko C. Role of deferiprone in chelation therapy for transfusional iron overload. Blood 2003; 102:17-24. Review of the deferiprone data, including reviews, studies, and reports in the literature as of 2003. Provides summary details of outcomes including ferritin, liver iron, cardiac iron, and adverse events.
    • (2003) Blood , vol.102 , pp. 17-24
    • Hoffbrand, A.V.1    Cohen, A.2    Hershko, C.3
  • 37
    • 0042943205 scopus 로고    scopus 로고
    • Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone
    • Cohen AR, Galanello R, Piga A, et al. Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone. Blood 2003; 102:1583-1587. Four-year follow-up data on patients who were early reported in a 1-year prospective study of chelation treatment with deferiprone. No useful measurements of efficacy are provided.
    • (2003) Blood , vol.102 , pp. 1583-1587
    • Cohen, A.R.1    Galanello, R.2    Piga, A.3
  • 38
    • 0038486942 scopus 로고    scopus 로고
    • Clinical trial of deferiprone iron chelation therapy in beta-thalassaemia/haemoglobin e patients in Thailand
    • Pootrakul P, Sirankapracha P, Sankote J, et al. Clinical trial of deferiprone iron chelation therapy in beta-thalassaemia/haemoglobin E patients in Thailand. Br J Haematol 2003; 122:305-310. Nine patients with thalassemia not requiring chronic transfusion therapy were given lower than the 'standard' dose of deferiprone and demonstrated decreases in liver iron, ferritin, and red blood cell membrane iron.
    • (2003) Br J Haematol , vol.122 , pp. 305-310
    • Pootrakul, P.1    Sirankapracha, P.2    Sankote, J.3
  • 39
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
    • Piga A, Gaglioti C, Fogliacco E, Tricta F. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica 2003; 88:489-496. This retrospective review of deferiprone versus deferoxamine in patients with thalassemia major reported improved cardiac outcomes in patients treated with deferiprone. Much controversy was generated by this because of the retrospective nature and the fact that the two groups did not seem well matched.
    • (2003) Haematologica , vol.88 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3    Tricta, F.4
  • 40
    • 3543058868 scopus 로고    scopus 로고
    • Combined therapy with Desferrioxamine and Deferiprone: A New Protocol for Iron Chelation in Thalassemia
    • D'Angelo E, Mirra N, Rocca A, Carnelli V. Combined therapy With Desferrioxamine and Deferiprone: a New Protocol for Iron Chelation in Thalassemia. J Pediatr Hematol Oncol 2004; 26:451-453.
    • (2004) J Pediatr Hematol Oncol , vol.26 , pp. 451-453
    • D'Angelo, E.1    Mirra, N.2    Rocca, A.3    Carnelli, V.4
  • 41
    • 0242584372 scopus 로고    scopus 로고
    • Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
    • Mourad FH, Hoffbrand AV, Sheikh-Taha M, et al. Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. Br J Haematol 2003; 121:187-189. Randomized, controlled study of patients with transfusion-dependent thalassemia comparing deferoxamine alone to deferoxamine and deferiprone demonstrating that the combination therapy, with both drugs at standard doses, could be given safely.
    • (2003) Br J Haematol , vol.121 , pp. 187-189
    • Mourad, F.H.1    Hoffbrand, A.V.2    Sheikh-Taha, M.3
  • 42
    • 0037906104 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia
    • Galanello R, Piga A, Alberti D, et al. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia. J Clin Pharmacol 2003; 43:565-572. Preliminary study of ICL670 that demonstrated its safety in single doses up to as high as 80 mg/kg.
    • (2003) J Clin Pharmacol , vol.43 , pp. 565-572
    • Galanello, R.1    Piga, A.2    Alberti, D.3
  • 43
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown E, Olivieri NF, Giardina PJ, et al. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2003; 361:1597-1602. Iron-balance study of ICL670 that demonstrated equal efficacy of 20 mg/kg of ICL670 and 40 mg/kg of deferoxamine and demonstrated the 24-hour blood levels of ICL670, which may be of benefit as protection against iron-induced free radical damage.
    • (2003) Lancet , vol.361 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3
  • 44
    • 1542352269 scopus 로고    scopus 로고
    • Phase II study of ICL670, an oral chelator, in adult thalassaemia patients with transfusional iron overload: Efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) after 18 months of therapy
    • Piga A, Galanello R, Cappellini M, et al. Phase II study of ICL670, an oral chelator, in adult thalassaemia patients with transfusional iron overload: Efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) after 18 months of therapy. Blood 2003; 102:121A. Although published thus far only in abstract form, it reports the only published data on the largest group of patients treated with ICL670 for a prolonged period of time.
    • (2003) Blood , vol.102
    • Piga, A.1    Galanello, R.2    Cappellini, M.3
  • 45
    • 0037089226 scopus 로고    scopus 로고
    • HBED ligand: Preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning
    • Bergeron RJ, Wiegand J, Brittenham GM. HBED ligand: Preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning. Blood 2002; 99:3019-3026.
    • (2002) Blood , vol.99 , pp. 3019-3026
    • Bergeron, R.J.1    Wiegand, J.2    Brittenham, G.M.3
  • 46
    • 0038603210 scopus 로고    scopus 로고
    • Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells
    • Link G, Ponka P, Konijn AM, et al. Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells. Blood 2003; 101:4172-4179.
    • (2003) Blood , vol.101 , pp. 4172-4179
    • Link, G.1    Ponka, P.2    Konijn, A.M.3
  • 47
    • 0037411115 scopus 로고    scopus 로고
    • Beta-thalassaemia: Emergence of new and improved iron chelators for treatment
    • Wong C, Richardson DR. Beta-thalassaemia: Emergence of new and improved iron chelators for treatment. Int J Biochem Cell Biol 2003; 35:1144-1149.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1144-1149
    • Wong, C.1    Richardson, D.R.2
  • 49
    • 14644422467 scopus 로고    scopus 로고
    • The safety and pharmacokinetics of GT56-252, a novel orally available iron chelator
    • 38th Annual Meeting of the European Society for Clinical Investigation
    • Donovan JM, Palmer PA, Plone MA, Wonke B. The safety and pharmacokinetics of GT56-252, a novel orally available iron chelator. 38th Annual Meeting of the European Society for Clinical Investigation. Eur J of Clin Invest 2004; 139:39.
    • (2004) Eur J of Clin Invest , vol.139 , pp. 39
    • Donovan, J.M.1    Palmer, P.A.2    Plone, M.A.3    Wonke, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.