Plasma carnitine levels in preterm infants with respiratory distress syndrome

Pediatrics International

Volumn 47, Issue 1, 2005, Pages 49-52

  Korkmaz, Ayse ^a,b   Tekinalp, Gulsevin ^a   Coskun, Turgay ^a   Yigit, Sule ^a   Yurdakok, Murat ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Pediat Metab and Nutrition Unit ^*  (Turkey)

Author keywords

Carnitine; Newborn; Pulmonary surfactant; Respiratory distress syndrome

Indexed keywords

CARNITINE; LUNG SURFACTANT;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FETUS LUNG MATURATION; HUMAN; LUNG PARENCHYMA; MALE; MATERNAL BLOOD; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN; PATHOGENESIS; PLACENTAL TRANSFER; PREMATURITY; PRENATAL CARE; PRIORITY JOURNAL; PROTEIN DETERMINATION;

CARNITINE; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 14644433703     PISSN: 13288067     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-200x.2005.01998.x     Document Type: Article

References (20)

1. Scaglia F, Longo N. Primary and secondary alterations of neonatal carnitine metabolism. Semin. Perinatol. 1999; 23: 152-61.
2. Bahl JJ, Bressler R. The pharmacology of carnitine. Annu. Rev. Pharmacol. Toxicol. 1987; 27: 257-77.
3. Shenai JP, Borum PR, Mohan P, Donlevy SC. Carnitine status at birth of newborn infants of varying gestation. Pediatr. Res. 1983; 17: 579-82.
4. Giannacopoulou C, Evangeliu A, Matalliotakis I et al. Effects of gestation age and birth weight in the concentration of carnitine in the umbilical plasma. Clin. Exp. Obstet. Gynecol. 1998; 25: 42-5.
5. Shenai JP, Borum PR. Tissue carnitine reserves of newborn infants. Pediatr. Res. 1984; 18: 679-81.
6. Koumantakis E, Evangeliu A, Sifakis S et al. Comparative study of plasma carnitine determination in the neonate and in normal delivery. Clin. Exp. Obstet. Gynecol. 1997; 24: 174-7.
7. Cederblag G, Niklasson A, Rydgren B, Albertsson-Wikland K, Olegard R. Carnitine in maternal and neonatal plasma. Acta Paediatr. Scand. 1985; 74: 500-4.
8. Novak M, Monkus EF, Chung D, Buch M. Carnitine in the perinatal metabolism of lipids I: relationship between maternal and fetal plasma levels of carnitine and acylcarnitines. Pediatrics 1981; 67: 95-100.
9. Salzer S, Husslein P, Lohninger A et al. 1st report: alternatives to cortisone therapy. First clinical experiences with a carnitine-betamethasone combination for the stimulation of fetal lung maturity. Wien. Klin. Wochenschr. 1983; 95: 724-8.
10. Lohninger A, Krieglsteiner P, Nikiforov A et al. Comparison of the effects of betamethasone and 1-carnitine on dipalmitoyl-phosphatidylcholine content and phosphatidylcholine species composition in fetal rat lungs. Pediatr. Res. 1984; 18: 1246-52.
11. Lohninger A, Krieglsteiner HP, Salzer H, Erhardt W, Eppl W, Kaiser E. Studies on the effects of L-thyroxine, L-carnitine and L-thyroxine-L-carnitine combination on dipalmitoyl phosphatidylcholine content and on phosphatidylcholine species composition in fetal rat lungs. Pediatr. Res. 1986; 20: 1280-3.
12. Lohninger A, Bock B, Dadak C, Feiks A, Kaiser E. Effect of carnitine on foetal rat lung dipalmitoyl phosphatidylcholine content and lung morphology. J. Clin. Chem. Clin. Biochem. 1990; 28: 313-18.
13. Kurz C, Arbeiter K, Obermair A, Salzer H, Salzer HR, Lohninger A. L-carnitine-bethamethasone combination therapy versus bethamethasone therapy alone in prevention of respiratory distress syndrome. Z. Geburtshilfe Perinatol. 1993; 197: 215-19.
14. Lohninger A, Laschan C, Auer B, Linhart L, Salzer H. Animal experiment and clinical studies of the significance of carnitine for energy metabolism in pregnant patients and the fetus during the pre- and perinatal period. Wien. Klin. Wochenschr. 1996; 108: 33-9.
15. Lohninger A, Krieglsteiner HP, Hajos F, Stangl H, Marz R. Effects of prenatal treatment with betamethasone, L-carnitine or betamethasone-L-carnitine combinations on the phosphatidylcholine content and composition of the foetal and maternal rat lung. Eur. J. Clin. Chem. Clin. Biochem. 1996; 34: 387-91.
16. Lohninger A, Auer B, Lechner S, Salzer H. Prenatal effects of betamethasone-L-carnitine combination on fetal rat lung. J. Perinat. Med. 1996; 24: 591-9.
17. Arenas J, Rubio JC, Martin MA, Campos Y. Biological roles of L-carnitine in perinatal metabolism. Early Hum. Dev. 1998; 53 (Suppl.): S43-50.
18. Hansen T, Corbert A. Disorders of the transition. In: Taeusch HW, Ballard RA (eds). Avery's Diseases of the Newborn, 7th edn. W.B. Saunders, Philadelphia, 1998; 602-29.
19. Marquis NR, Fritz IB. Enzymological determination of free carnitine concentrations in rat tissues. J. Lipid Res. 1964; 5: 184-7.
20. Goni FM, Requero MA, Alonso A. Palmitoylcarnitine, a surface-active metabolite. FEBS Lett. 1996; 390: 1-5.