Sitostanetriol is not formed in vivo from sitosterol in the rat

Reproduction Nutrition Development

Volumn 44, Issue 6, 2004, Pages 609-616

  Grandgirard, André ^a   Martine, Lucy ^a   Juanéda, Pierre ^a   Cordelet, Catherine ^a  

^a CEMAGREF   (France)

Author keywords

Oxyphytosterol; Phytosterol; Plasma; Sitostanetriol

Indexed keywords

PHYTOSTEROL; SITOSTANETRIOL; SITOSTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL FOOD; ARTICLE; BLOOD ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DIET RESTRICTION; EXCRETION; FOOD COMPOSITION; GAS CHROMATOGRAPHY; IN VIVO STUDY; LIPID COMPOSITION; LIPOGENESIS; MASS SPECTROMETRY; NONHUMAN; PURIFICATION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; CHROMATOGRAPHY, GAS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; OXIDATION-REDUCTION; PHYTOSTEROLS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SITOSTEROLS; TRIGLYCERIDES;

EID: 14644415522     PISSN: 09265287     EISSN: None     Source Type: Journal    
DOI: 10.1051/rnd:2004057     Document Type: Article

References (23)

1. Piironen V, Lindsay DG, Miettinen TA, Toivo J, Lampi AM. Plant sterols: biosynthesis, biological function and their importance to human nutrition. J Sci Food Agric 2000, 80: 939-966.
2. Plat J, Kerckhoffs DAJM, Mensink RP. Therapeutic potential of plant sterols and stanols. Curr Opin Lipidol 2000, 11: 571-576.
3. Moreau RA, Whitaker BD, Hicks KB. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. Progr Lipid Res 2002, 41: 457-500.
4. Daly GG, Finocchiaro ET, Richardson T. Characterization of some oxidation products of beta-sitosterol. J Agric Food Chem 1983, 31: 46-50.
5. Dutta PC, Savage GP, Formation and content of phytosterol oxidation products in foods. In: Guardiola F, Dutta PC, Codony R, Savage GP (Eds), Cholesterol and phytosterol oxidation products. Analysis, occurrence, and biological effects, AOCS Press, Champaign (Illinois), 2002, p 319-334.
6. Grandgirard A, Martine L, Joffre C, Juaneda P, Berdeaux O. Gas chromatographic and mass spectrometric identification of mixtures of oxyphytosterol and oxycholesterol derivatives. Application to a phytosterol-enriched food. J Chromatogr A 2004, 1040: 239-250.
7. Grandgirard A, Martine L, Demaison L, Cordelet C, Joffre C, Berdeaux O, Semon E. Oxyphytosterols are present in plasma of healthy human subjects. Br J Nutr 2004, 91: 101-106.
8. Grandgirard A, Sergiel JP, Nour M, Demaison-Meloche J, Ginies C. Lymphatic absorption of phytosterol oxides in rats. Lipids 1999, 34: 563-570.
9. Grandgirard A, Delaison-Meloche J, Cordelet C, Demaison L. Incorporation of oxyphytosterols in tissues of hamster. Reprod Nutr Dev 2004, 44: 599-608.
10. Ostlund RE, Racette SB, Okeke A, Stenson WF. Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. Am J Clin Nutr 2002, 75: 1000-1004.
11. Moilanen T, Nikkari T. The effect of storage on the fatty acid composition of human serum. Clin Chim Acta 1981, 114: 111-116.
12. Lai SM, Gray JI, Zabik ME. Evaluation of solid phase extraction and gas chromatography for determination of cholesterol oxidation products in spray-dried whole egg. J Agric Food Chem 1995, 43: 1122-1126.
13. Sanders DJ, Minter HJ, Howes D, Hepburn PA. The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat. Food Chem Toxicol 2000, 38: 485-491.
14. Dutta PC, Determination of phytosterol oxidation products in foods and biological samples. In: Guardiola F, Dutta PC, Codony R, Savage GP. (Eds), Cholesterol and phytosterol oxidation products. Analysis, occurrence, and biological effects, AOCS Press, Champaign (Illinois), 2002, p 335-374.
15. Johnsson L, Dutta PC. Characterization of side-chain oxidation products of sitosterol and campesterol by chromatographic and spectroscopic methods. J Am Oil Chem Soc 2003, 80: 767-776.
16. Johnsson L, Andersson RE, Dutta PC. Side-chain autoxidation of stigmasterol and analysis of a mixture of phytosterol oxidation products by chromatographic and spectroscopic methods. J Am Oil Chem Soc 2003, 80: 777-783.
17. Soupas L, Juntunen L, Saynajoki S, Lampi AM, Piironen V. GC-MS method for characterization and quantification of sitostanol oxidation products. J Am Oil Chem Soc 2004, 81: 135-141.
18. Breuer O, Bjorkhem I. Use of an 18-O(2) inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat - Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. J Biol Chem 1995, 270: 20278-20284.
19. Maerker G, Nungesser EH, Bunick FJ. Reaction of cholesterol 5,6-epoxides with simulated gastric juice. J Am Oil Chem Soc 1988, 23: 761-765.
20. Guardiola F, Codony R, Rafecas M, Boatella J. Oxysterol formation in foods. Grasas Y Aceites 1995, 46: 202-212.
21. Peng SK, Tham P, Taylor CB, Mikkelson B. Cytotoxicity of oxidation derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis. Am J Clin Nutr 1979, 32: 1033-1042.
22. Jacobson MS, Price MG, Shamoo AE, Heald FP. Atherogenesis in White Carneau pigeons Effects of low-level cholestane-triol feeding. Atherosclerosis 1985, 57: 209-217.
23. Matthias D, Becker CH, Godicke W, Schmidt R, Ponsold K. Action of cholestane-3beta, 5alpha,6beta-triol on rats with particular reference to aorta. Atherosclerosis 1987, 63: 115-124.