Comparison of carcinogenic and in vivo genotoxic potency estimates

Basic and Clinical Pharmacology and Toxicology

Volumn 96, Issue 2, 2005, Pages 131-139

  Sanner, Tore ^a   Dybing, Erik ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMO 3 CHLOROPROPANE; 1,2 DIBROMOETHANE; 1,2 DIMETHYLHYDRAZINE; 1,3 BUTADIENE; 2,4 DINITROTOLUENE; ACETAMIDE; ACRYLAMIDE; ATRAZINE; BENZENE; BIS(2 HYDROXYETHYL)NITROSAMINE; BROMODICHLOROMETHANE; CARCINOGEN; CATECHOL; CHLORAL HYDRATE; CHLORDANE; CHLOROFORM; DIAZEPAM; DICHLOROACETIC ACID; DIOXANE; DOXYLAMINE; ETHYLENE OXIDE; GRISEOFULVIN; HEXACHLOROBUTADIENE; HYDROQUINONE; MESYLIC ACID METHYL ESTER; METHYLTHIOURACIL; MUTAGENIC AGENT; NAPHTHALENE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; UNINDEXED DRUG;

ARTICLE; CARCINOGENESIS; CARCINOGENICITY; COMPARATIVE STUDY; CORRELATION ANALYSIS; EXPOSURE; GENOTOXICITY; IN VIVO STUDY; PRIORITY JOURNAL; TOXICITY TESTING;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMAL DISEASES; ANIMALS; CARCINOGENS; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; INFORMATION DISSEMINATION; MICE; MODELS, ANIMAL; MUTAGENICITY TESTS; MUTAGENS; RATS; RISK ASSESSMENT;

ANIMALIA;

EID: 14644392789     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2005.pto960207.x     Document Type: Article

References (20)

1. Abramsson-Zetterberg, L.: The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat. Res. 2003, 535, 215-222.
2. Ashby, J. & R. W. Tennant: Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutat Res. 1988, 204, 17-115.
3. Dybing, E., T. Sanner, H. Roelfzema, D. Kroese & R. W. Tennant: T25: A simplified carcinogenic potency index: Description of the system and study of correlations between carcinogenic potency and species/site specificity and mutagenicity. Pharmacology & Toxicology 1997, 80, 272-279.
4. EC: Guidelines for setting specific concentration limits for carcinogens in Annex I of directive 67/548/EEC. Inclusion of potency considerations. Commission working group on the classification and labelling of dangerous substances. Brussel 1999.
5. Fassina, G., A. Abbondandolo, L. Mariani, M. Taningher & S. Parodi: Mutagenicity in V79 cells does not correlate with carcinogenic in small rodents for 12 aromatic amines. J. Environ. Health 1990, 29, 109-130.
6. Hengstler, J. G., M. S. Bogdanffy, H. M. Bolt & F. Oesch: Callenging dogma - thresholds for genotoxic carcinogens? The case of vinyl acetate. Annu. Rev. Pharmacol. Toxicol. 2003, 43, 485-520.
7. IARC Monographs on the evaluation of carcinogenic risks to humans: Polychlorinated dibenzo-para-dioxins. Lyon, France 1997, 69, 33-423.
8. IARC Monographs on the evaluation of carcinogenic risks to humans: Atrazine. Lyon, France 1999, 73, 59-113.
9. Jones, C. A., P. J. Marlino, W. Lijinsky & E. Huberman: The relationship between the carcinogenicity and mutagenicity of nitrosamines in a hepatocyte-mediated mutagenicity assay. Carcinogenesis 1981, 2, 1075-1077.
10. Lijinsky W: Carcinogenicity and mutagenicity of N-nitroso compounds. Mol. Toxicol. 1987, 1, 107-119.
11. Parodi, S., M. Taningher, P. Romano, S. Grilli & L. Santi: Mutagenic and carcinogenic potency indices and their correlation. Teratog. Carcinog. Mutagen. 1990, 10, 177-197.
12. Sanner, T., E. Dybing, M. I. Willems, & D. Kroese: A simple method for quantitative risk assessment of non-threshold carcinogens based on the dose descriptor T25. Pharmacology & Toxicology 2001, 88, 331-341.
13. Sanner, T. & E. Dybing: Comparison of carcinogen hazard characterisation based on animal studies and epidemiology. Basic & Clinical Pharmacology & Toxicology 2005, 96, 66-70.
14. Sbrana, I., D. Lascialfari & N. Loprieno: TCE induces micronuclei but not chromosomal aberrations in mouse bone marrow cells. IV ICEM, Stockholm. 1985. p. 163.
15. SCCNFP. The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. The SCCNFP's notes of guidance for the testing of cosmetic ingredients and their safety evaluation. 5th Revision. Adopted by the SCCNFP during the 25th plenary meeting of 20 October 2003, Brussels.
16. Streffer, C., H. M. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jacob, D. Oughton, K. Priess, E. Rehbinder & E. Swaton: Environmental standards - dose-effect relations in the low dose range and risk evaluation. Springer-Verlag, Berlin 2004.
17. Tomita, I., Y. Nakamura, N. Aoki & N. Inui: Mutagenic/carcinogenic potential of DEHP and MEHP Environ. Health Perspect. 1982, 45, 119-125.
18. US. Environmental Protection Agency: Guidelines for Carcinogen Risk Assessment. Fed. Reg. 1986, 51, 33992-34003.
19. US. Environmental Protection Agency: Proposed guidelines for carcinogen risk assessment. Fed. Reg. 1996, 61, 17960-18011.
20. Waters, M. D., H. F. Stack, A. L. Brady P. H. M. Lohman, L. Haroun & H. Vainio: Activity profiles for genetic and related tests. IARC Monographs on the evaluation of carcinogenic risks to humans. Lyon, France 1987, Suppl 6, 687-690.