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Volumn 12, Issue 2, 2005, Pages 117-122

Controlling the complement system for prevention of red cell destruction

Author keywords

Anti C5; Autoimmune hemolytic anemia; Complement; Complement inhibitors; Complement receptors; Paroxysmal nocturnal hemoglobinuria; Sickle cell disease; Transfusion reactions

Indexed keywords

COMPLEMENT INHIBITOR; NAFAMSTAT MESILATE;

EID: 14644390314     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.moh.0000151712.53957.01     Document Type: Review
Times cited : (14)

References (80)
  • 2
    • 0025158532 scopus 로고
    • Reports of 355 transfusion-associated deaths: 1976 Through 1985
    • Sazama K. Reports of 355 transfusion-associated deaths: 1976 through 1985. Transfusion 1990; 30:583-590.
    • (1990) Transfusion , vol.30 , pp. 583-590
    • Sazama, K.1
  • 3
    • 0016256607 scopus 로고
    • Correlations between quantitative assay of red cell-bound C3, serologic reactions, and hemolytic anemia
    • Fischer JT, Petz LD, Garratty G, Cooper NR. Correlations between quantitative assay of red cell-bound C3, serologic reactions, and hemolytic anemia. Blood 1974; 44:359-373.
    • (1974) Blood , vol.44 , pp. 359-373
    • Fischer, J.T.1    Petz, L.D.2    Garratty, G.3    Cooper, N.R.4
  • 4
    • 0034618113 scopus 로고    scopus 로고
    • A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
    • Taylor PR, Carugati A, Fadok VA, et al. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 2000; 192:359-366.
    • (2000) J Exp Med , vol.192 , pp. 359-366
    • Taylor, P.R.1    Carugati, A.2    Fadok, V.A.3
  • 5
    • 0033990632 scopus 로고    scopus 로고
    • The role of complement in B cell activation and tolerance
    • Carroll MC. The role of complement in B cell activation and tolerance. Adv Immunol 2000; 74:61-88.
    • (2000) Adv Immunol , vol.74 , pp. 61-88
    • Carroll, M.C.1
  • 6
    • 0035652286 scopus 로고    scopus 로고
    • Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein
    • Boackle SA, Holers VM, Chen X, et al. Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein. Immunity 2001; 15:775-785.
    • (2001) Immunity , vol.15 , pp. 775-785
    • Boackle, S.A.1    Holers, V.M.2    Chen, X.3
  • 7
    • 0032211714 scopus 로고    scopus 로고
    • A critical role for complement in maintenance of self-tolerance
    • Prodeus AP, Goerg S, Shen LM, et al. A critical role for complement in maintenance of self-tolerance. Immunity 1998; 9:721-731.
    • (1998) Immunity , vol.9 , pp. 721-731
    • Prodeus, A.P.1    Goerg, S.2    Shen, L.M.3
  • 8
    • 0036681645 scopus 로고    scopus 로고
    • A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus
    • Wu X, Jiang N, Deppong C, et al. A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus. J Immunol 2002; 169:1587-1592.
    • (2002) J Immunol , vol.169 , pp. 1587-1592
    • Wu, X.1    Jiang, N.2    Deppong, C.3
  • 9
    • 0026099699 scopus 로고
    • Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology
    • Hebbel RP. Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology. Blood 1991; 77:214-237.
    • (1991) Blood , vol.77 , pp. 214-237
    • Hebbel, R.P.1
  • 10
    • 0023689124 scopus 로고
    • Complement activation in sickle cell disease: A liposome model
    • Tomasko MA, Chudwin DS. Complement activation in sickle cell disease: a liposome model. J Lab Clin Med 1988; 112:248-253.
    • (1988) J Lab Clin Med , vol.112 , pp. 248-253
    • Tomasko, M.A.1    Chudwin, D.S.2
  • 11
    • 0027181206 scopus 로고
    • Activation of the alternative complement pathway by exposure of phosphatidylethanolamine and phosphatidylserine on erythrocytes from sickle cell disease patients
    • Wang RH, Phillips G Jr, Medof ME, Mold C, Activation of the alternative complement pathway by exposure of phosphatidylethanolamine and phosphatidylserine on erythrocytes from sickle cell disease patients. J Clin Invest 1993; 92:1326-1335.
    • (1993) J Clin Invest , vol.92 , pp. 1326-1335
    • Wang, R.H.1    Phillips Jr., G.2    Medof, M.E.3    Mold, C.4
  • 13
    • 0018425583 scopus 로고
    • Complement activation in asymptomatic patients with sickle cell anaemia
    • Wilson WA, Thomas EJ, Sissons JG. Complement activation in asymptomatic patients with sickle cell anaemia. Clin Exp Immunol 1979; 36:130-139.
    • (1979) Clin Exp Immunol , vol.36 , pp. 130-139
    • Wilson, W.A.1    Thomas, E.J.2    Sissons, J.G.3
  • 14
    • 0022382427 scopus 로고
    • Increased activation of the alternative complement pathway in sickle cell disease
    • Chudwin DS, Korenblit AD, Kingzette M, et al. Increased activation of the alternative complement pathway in sickle cell disease. Clin Immunol Immunopathol 1985; 37:93-97.
    • (1985) Clin Immunol Immunopathol , vol.37 , pp. 93-97
    • Chudwin, D.S.1    Korenblit, A.D.2    Kingzette, M.3
  • 15
    • 0017987223 scopus 로고
    • Alternative pathway activation in sickle cell disease and beta-thalassemia major
    • deCiutiis AC, Peterson CM, Polley MJ, Metakis LJ. Alternative pathway activation in sickle cell disease and beta-thalassemia major. J Natl Med Assoc 1978; 70:503-506.
    • (1978) J Natl Med Assoc , vol.70 , pp. 503-506
    • DeCiutiis, A.C.1    Peterson, C.M.2    Polley, M.J.3    Metakis, L.J.4
  • 16
    • 0029098827 scopus 로고
    • Complement activation during painful crisis in sickle cell anemia
    • Mold C, Tamerius JD, Phillips G Jr: Complement activation during painful crisis in sickle cell anemia. Clin Immunol Immunopathol 1995; 76:314-320.
    • (1995) Clin Immunol Immunopathol , vol.76 , pp. 314-320
    • Mold, C.1    Tamerius, J.D.2    Phillips Jr., G.3
  • 17
    • 0034307274 scopus 로고    scopus 로고
    • Activated monocytes in sickle cell disease: Potential role in the activation of vascular endothelium and vasoocclusion
    • Belcher JD, Marker PH, Weber JP, et al. Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vasoocclusion. Blood 2000; 96:2451-2459.
    • (2000) Blood , vol.96 , pp. 2451-2459
    • Belcher, J.D.1    Marker, P.H.2    Weber, J.P.3
  • 18
    • 0014434298 scopus 로고
    • Deficiency of pneumococcal serum opsonizing activity in sickle-cell disease
    • Winkelstein JA, Drachman RH. Deficiency of pneumococcal serum opsonizing activity in sickle-cell disease. N Engl J Med 1968; 279:459-466.
    • (1968) N Engl J Med , vol.279 , pp. 459-466
    • Winkelstein, J.A.1    Drachman, R.H.2
  • 19
    • 0028040030 scopus 로고
    • Defective regulation of complement by the sickle erythrocyte: Evidence for a defect in control of membrane attack complex formation
    • Test ST, Woolworth VS. Defective regulation of complement by the sickle erythrocyte: evidence for a defect in control of membrane attack complex formation. Blood 1994; 83:842-852.
    • (1994) Blood , vol.83 , pp. 842-852
    • Test, S.T.1    Woolworth, V.S.2
  • 20
    • 0021366320 scopus 로고
    • Complement activation by the surface of Plasmodium falciparum infected erythrocytes
    • Stanley HA, Mayes JT, Cooper NR, Reese RT. Complement activation by the surface of Plasmodium falciparum infected erythrocytes. Mol Immunol 1984; 21:145-150.
    • (1984) Mol Immunol , vol.21 , pp. 145-150
    • Stanley, H.A.1    Mayes, J.T.2    Cooper, N.R.3    Reese, R.T.4
  • 21
    • 0026688902 scopus 로고
    • Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: Involvement of immune and nonimmune determinants and dependence on parasite developmental stage
    • Turrini F, Ginsburg H, Bussolino F, et al. Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: involvement of immune and nonimmune determinants and dependence on parasite developmental stage. Blood 1992; 80:801-808.
    • (1992) Blood , vol.80 , pp. 801-808
    • Turrini, F.1    Ginsburg, H.2    Bussolino, F.3
  • 22
    • 0034651546 scopus 로고    scopus 로고
    • Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia
    • Waitumbi JN, Opollo MO, Muga RO, et al. Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia. Blood 2000; 95:1481-1486.
    • (2000) Blood , vol.95 , pp. 1481-1486
    • Waitumbi, J.N.1    Opollo, M.O.2    Muga, R.O.3
  • 23
    • 0035016684 scopus 로고    scopus 로고
    • Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytes
    • Giribaldi G, Ulliers D, Mannu F, et al. Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytes. Br J Haematol 2001; 113:492-499.
    • (2001) Br J Haematol , vol.113 , pp. 492-499
    • Giribaldi, G.1    Ulliers, D.2    Mannu, F.3
  • 25
    • 0035467569 scopus 로고    scopus 로고
    • Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria
    • Goka BQ, Kwarko H, Kurtzhals JA, et al. Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 2001; 95:545-549.
    • (2001) Trans R Soc Trop Med Hyg , vol.95 , pp. 545-549
    • Goka, B.Q.1    Kwarko, H.2    Kurtzhals, J.A.3
  • 26
    • 4444340345 scopus 로고    scopus 로고
    • Age-related changes in red blood cell complement regulatory proteins and susceptibility to severe malaria
    • Waitumbi JN, Donvito B, Kisserli A, et al. Age-related changes in red blood cell complement regulatory proteins and susceptibility to severe malaria. J Infect Dis 2004; 190:1183-1191.
    • (2004) J Infect Dis , vol.190 , pp. 1183-1191
    • Waitumbi, J.N.1    Donvito, B.2    Kisserli, A.3
  • 27
    • 0001668825 scopus 로고
    • Studies on destruction of red cell blood cells. I. Chronic hemolytic anemia with paroxysmal hemoglobinuria: An investigation of the mechanism of hemolysis, with observations on five cases
    • Ham TH. Studies on destruction of red cell blood cells. I. Chronic hemolytic anemia with paroxysmal hemoglobinuria: an investigation of the mechanism of hemolysis, with observations on five cases. Arch Intern Med 1939; 64:1271.
    • (1939) Arch Intern Med , vol.64 , pp. 1271
    • Ham, T.H.1
  • 28
    • 0000037147 scopus 로고
    • Studies on destruction of red blood cells. II. Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria: Certain immunological aspects of the hemolytic mechanism with special reference to serum complement
    • Ham TH, Dingle JH. Studies on destruction of red blood cells. II. Chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria: certain immunological aspects of the hemolytic mechanism with special reference to serum complement. J Clin Invest 1939; 18:657-672.
    • (1939) J Clin Invest , vol.18 , pp. 657-672
    • Ham, T.H.1    Dingle, J.H.2
  • 29
    • 0024411828 scopus 로고
    • Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria
    • Holguin MH, Fredrick LR, Bernshaw NJ, et al. Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria. J Clin Invest 1989; 84:7-17.
    • (1989) J Clin Invest , vol.84 , pp. 7-17
    • Holguin, M.H.1    Fredrick, L.R.2    Bernshaw, N.J.3
  • 30
    • 0025233715 scopus 로고
    • The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9
    • Rollins SA, Sims PJ. The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9. J Immunol 1990; 144:3478-3483.
    • (1990) J Immunol , vol.144 , pp. 3478-3483
    • Rollins, S.A.1    Sims, P.J.2
  • 31
    • 0024376667 scopus 로고
    • Studies on the sensitivity to complement-mediated lysis of erythrocytes (Inab phenotype) with a deficiency of DAF (decay accelerating factor)
    • Merry AH, Rawlinson VI, Uchikawa M, et al. Studies on the sensitivity to complement-mediated lysis of erythrocytes (Inab phenotype) with a deficiency of DAF (decay accelerating factor). Br J Haematol 1989; 73:248-253.
    • (1989) Br J Haematol , vol.73 , pp. 248-253
    • Merry, A.H.1    Rawlinson, V.I.2    Uchikawa, M.3
  • 32
    • 0024333970 scopus 로고
    • The Inab phenotype: Characterization of the membrane protein and complement regulatory defect
    • Telen MJ, Green AM. The Inab phenotype: characterization of the membrane protein and complement regulatory defect. Blood 1989; 74:437-441.
    • (1989) Blood , vol.74 , pp. 437-441
    • Telen, M.J.1    Green, A.M.2
  • 33
    • 0025053264 scopus 로고
    • Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria
    • Yamashina M, Ueda E, Kinoshita T, et al. Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria. N Engl J Med 1990; 323:1184-1189.
    • (1990) N Engl J Med , vol.323 , pp. 1184-1189
    • Yamashina, M.1    Ueda, E.2    Kinoshita, T.3
  • 34
    • 0026802999 scopus 로고
    • Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene
    • Motoyama N, Okada N, Yamashina M, Okada H. Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. Eur J Immunol 1992; 22:2669-2673.
    • (1992) Eur J Immunol , vol.22 , pp. 2669-2673
    • Motoyama, N.1    Okada, N.2    Yamashina, M.3    Okada, H.4
  • 35
    • 0026516830 scopus 로고
    • Analysis of the effects of activation of the alternative pathway of complement on erythrocytes with an isolated deficiency of decay accelerating factor
    • Holguin MH, Martin CB, Bernshaw NJ, Parker CJ. Analysis of the effects of activation of the alternative pathway of complement on erythrocytes with an isolated deficiency of decay accelerating factor. J Immunol 1992; 148:498-502.
    • (1992) J Immunol , vol.148 , pp. 498-502
    • Holguin, M.H.1    Martin, C.B.2    Bernshaw, N.J.3    Parker, C.J.4
  • 37
    • 0041563747 scopus 로고    scopus 로고
    • Complement therapeutics; history and current progress
    • Morgan BP, Harris CL. Complement therapeutics; history and current progress. Mol Immunol 2003; 40:159-170.
    • (2003) Mol Immunol , vol.40 , pp. 159-170
    • Morgan, B.P.1    Harris, C.L.2
  • 38
    • 0025913102 scopus 로고
    • Infectious diseases associated with complement deficiencies
    • Figueroa JE, Densen P. Infectious diseases associated with complement deficiencies. Clin Microbiol Rev 1991; 4:359-395.
    • (1991) Clin Microbiol Rev , vol.4 , pp. 359-395
    • Figueroa, J.E.1    Densen, P.2
  • 39
    • 0037443775 scopus 로고    scopus 로고
    • Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells
    • Potter PK, Cortes-Hernandez J, Quartier P, et al. Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells. J Immunol 2003; 170:3223-3232.
    • (2003) J Immunol , vol.170 , pp. 3223-3232
    • Potter, P.K.1    Cortes-Hernandez, J.2    Quartier, P.3
  • 40
    • 0028303224 scopus 로고
    • Cytokine roles in hemolytic and nonhemolytic transfusion reactions
    • Davenport RD, Kunkel SL. Cytokine roles in hemolytic and nonhemolytic transfusion reactions [review]. Transfus Med Rev 1994; 8:157-168.
    • (1994) Transfus Med Rev , vol.8 , pp. 157-168
    • Davenport, R.D.1    Kunkel, S.L.2
  • 41
    • 9644267431 scopus 로고    scopus 로고
    • Transfusion errors: Scope of the problem, consequences, and solutions
    • Sazama K. Transfusion errors: scope of the problem, consequences, and solutions. Curr Hematol Rep 2003; 2:518-521.
    • (2003) Curr Hematol Rep , vol.2 , pp. 518-521
    • Sazama, K.1
  • 42
    • 0025354456 scopus 로고
    • Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardiai inflammation and necrosis
    • Weisman HF, Bartow T, Leppo MK, et al. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardiai inflammation and necrosis. Science 1990; 249:146-151.
    • (1990) Science , vol.249 , pp. 146-151
    • Weisman, H.F.1    Bartow, T.2    Leppo, M.K.3
  • 43
    • 4644237694 scopus 로고    scopus 로고
    • Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass
    • Lazar HL, Bokesch PM, van Lenta F, et al. Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass. Circulation 2004; 110:11274-11279. In this randomized, placebo-controlled study that enrolled 564 high-risk patients undergoing cardiac surgery, sCR1 was shown to significantly decrease the incidence of mortality and myocardial infarction in male patients.
    • (2004) Circulation , vol.110 , pp. 11274-11279
    • Lazar, H.L.1    Bokesch, P.M.2    Van Lenta, F.3
  • 44
    • 0032801926 scopus 로고    scopus 로고
    • Complement inhibition attenuates human lung transplant reperfusion injury: A multicenter trial
    • Zamora MR, Davis RD, Keshavjee SH, et al. Complement inhibition attenuates human lung transplant reperfusion injury: a multicenter trial. Chest 1999; 116:46S.
    • (1999) Chest , vol.116
    • Zamora, M.R.1    Davis, R.D.2    Keshavjee, S.H.3
  • 45
    • 0033796723 scopus 로고    scopus 로고
    • Phase I trial of the recombinant soluble complement receptor 1 in acute lung injury and acute respiratory distress syndrome
    • Zimmerman JL, Dellinger RP, Straube RC, Levin JL. Phase I trial of the recombinant soluble complement receptor 1 in acute lung injury and acute respiratory distress syndrome. Crit Care Med 2000; 28:3149-3154.
    • (2000) Crit Care Med , vol.28 , pp. 3149-3154
    • Zimmerman, J.L.1    Dellinger, R.P.2    Straube, R.C.3    Levin, J.L.4
  • 46
    • 0038044912 scopus 로고    scopus 로고
    • Complement receptor 1 inhibitors for prevention of immune-mediated red cell destruction: Potential use in transfusion therapy
    • Yazdanbakhsh K, Kang S, Tamasauskas D, et al. Complement receptor 1 inhibitors for prevention of immune-mediated red cell destruction: potential use in transfusion therapy. Blood 2003; 101:5046-5052.
    • (2003) Blood , vol.101 , pp. 5046-5052
    • Yazdanbakhsh, K.1    Kang, S.2    Tamasauskas, D.3
  • 47
    • 13144303521 scopus 로고    scopus 로고
    • Characterization of complement receptor 1 domains for prevention of complement-mediated red cell destruction
    • in press
    • Mqadmi A, Abdullah Y, Yazdanbakhsh K. Characterization of complement receptor 1 domains for prevention of complement-mediated red cell destruction. Transfusion 2005 (in press).
    • (2005) Transfusion
    • Mqadmi, A.1    Abdullah, Y.2    Yazdanbakhsh, K.3
  • 48
    • 0030013492 scopus 로고    scopus 로고
    • Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library
    • Sahu A, Kay BK, Lambris JD. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol 1996; 157:884-891.
    • (1996) J Immunol , vol.157 , pp. 884-891
    • Sahu, A.1    Kay, B.K.2    Lambris, J.D.3
  • 49
    • 0036865206 scopus 로고    scopus 로고
    • Structural aspects and design of low-molecular-mass complement inhibitors
    • Morikis D, Lambris JD. Structural aspects and design of low-molecular-mass complement inhibitors. Biochem Soc Trans 2002; 30:1026-1036.
    • (2002) Biochem Soc Trans , vol.30 , pp. 1026-1036
    • Morikis, D.1    Lambris, J.D.2
  • 50
    • 0019817468 scopus 로고
    • New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin
    • Fujii S, Hitomi Y. New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin. Biochim Biophys Acta 1981; 661:342-345.
    • (1981) Biochim Biophys Acta , vol.661 , pp. 342-345
    • Fujii, S.1    Hitomi, Y.2
  • 51
    • 0026088150 scopus 로고
    • FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a
    • Inagi R, Miyata T, Maeda K, et al. FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a. Immunol Lett 1991; 27:49-52.
    • (1991) Immunol Lett , vol.27 , pp. 49-52
    • Inagi, R.1    Miyata, T.2    Maeda, K.3
  • 52
    • 0027175686 scopus 로고
    • Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases
    • Miyata T, Fujita Y, Inagi R, et al. Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases. Lancet 1993; 341:1353.
    • (1993) Lancet , vol.341 , pp. 1353
    • Miyata, T.1    Fujita, Y.2    Inagi, R.3
  • 53
    • 0027489082 scopus 로고
    • Inhibitory effect of FUT-175 on complement activation and its application for glomerulonephritis with hypocomplementemia
    • Fujita Y, Inoue I, Inagi R, et al. Inhibitory effect of FUT-175 on complement activation and its application for glomerulonephritis with hypocomplementemia. Nippon Jinzo Gakkai Shi 1993; 35:393-397.
    • (1993) Nippon Jinzo Gakkai Shi , vol.35 , pp. 393-397
    • Fujita, Y.1    Inoue, I.2    Inagi, R.3
  • 55
    • 0030441149 scopus 로고    scopus 로고
    • Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv
    • Thomas TC, Rollins SA, Rother RP, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol 1996; 33:1389-1401.
    • (1996) Mol Immunol , vol.33 , pp. 1389-1401
    • Thomas, T.C.1    Rollins, S.A.2    Rother, R.P.3
  • 56
  • 57
    • 10744228553 scopus 로고    scopus 로고
    • Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria
    • Hillmen P, Hall C, Marsh JC, et al. Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 2004; 350:552-559. The prospect for use of a complement inhibitor for treatment of hemolytic diseases was demonstrated in this promising clinical study in which anti-C5 was administered to 11 patients with PNH and shown to reduce intravascular hemolysis, hemoglobinuria, and the need for transfusion.
    • (2004) N Engl J Med , vol.350 , pp. 552-559
    • Hillmen, P.1    Hall, C.2    Marsh, J.C.3
  • 58
    • 0035500616 scopus 로고    scopus 로고
    • Novel small molecule inhibitor of C1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits
    • Buerke M, Schwertz H, Seitz W, et al. Novel small molecule inhibitor of C1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits. J Immunol 2001; 167:5375-5380.
    • (2001) J Immunol , vol.167 , pp. 5375-5380
    • Buerke, M.1    Schwertz, H.2    Seitz, W.3
  • 59
    • 0035892756 scopus 로고    scopus 로고
    • Specific inhibition of the classical complement pathway by C1q-binding peptides
    • Roos A, Nauta AJ, Broers D, et al. Specific inhibition of the classical complement pathway by C1q-binding peptides. J Immunol 2001; 167:7052-7059.
    • (2001) J Immunol , vol.167 , pp. 7052-7059
    • Roos, A.1    Nauta, A.J.2    Broers, D.3
  • 60
    • 18744411773 scopus 로고    scopus 로고
    • Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits
    • Fung M, Loubser PG, Undar A, et al. Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits. J Thorac Cardiovasc Surg 2001; 122:113-122.
    • (2001) J Thorac Cardiovasc Surg , vol.122 , pp. 113-122
    • Fung, M.1    Loubser, P.G.2    Undar, A.3
  • 61
    • 0036864134 scopus 로고    scopus 로고
    • Targeting anticomplement agents
    • Smith RA. Targeting anticomplement agents. Biochem Soc Trans 2002; 30:1037-1041.
    • (2002) Biochem Soc Trans , vol.30 , pp. 1037-1041
    • Smith, R.A.1
  • 62
    • 0036784653 scopus 로고    scopus 로고
    • Bacterial expression and membrane targeting of the rat complement regulator Crry: A new model anticomplement therapeutic
    • Fraser DA, Harris CL, Smith RA, Morgan BP. Bacterial expression and membrane targeting of the rat complement regulator Crry: a new model anticomplement therapeutic. Protein Sci 2002; 11:2512-2521.
    • (2002) Protein Sci , vol.11 , pp. 2512-2521
    • Fraser, D.A.1    Harris, C.L.2    Smith, R.A.3    Morgan, B.P.4
  • 63
    • 1542781737 scopus 로고    scopus 로고
    • Generation of a recombinant, membrane-targeted form of the complement regulator CD59: Activity in vitro and in vivo
    • Fraser DA, Harris CL, Williams AS, et al. Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. J Biol Chem 2003; 278:48921-48927.
    • (2003) J Biol Chem , vol.278 , pp. 48921-48927
    • Fraser, D.A.1    Harris, C.L.2    Williams, A.S.3
  • 64
    • 0033022703 scopus 로고    scopus 로고
    • Structure-activity relationships within the N-terminal short consensus repeats (SCR) of human CR1 (C3b/ C4b receptor, CD35): SCR 3 plays a critical role in inhibition of the classical and alternative pathways of complement activation
    • Mossakowska D, Dodd I, Pindar W, Smith RA. Structure-activity relationships within the N-terminal short consensus repeats (SCR) of human CR1 (C3b/ C4b receptor, CD35): SCR 3 plays a critical role in inhibition of the classical and alternative pathways of complement activation. Eur J Immunol 1999; 29:1955-1965.
    • (1999) Eur J Immunol , vol.29 , pp. 1955-1965
    • Mossakowska, D.1    Dodd, I.2    Pindar, W.3    Smith, R.A.4
  • 65
    • 0037093245 scopus 로고    scopus 로고
    • Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack
    • Miwa T, Zhou L, Hilliard B, et al. Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack. Blood 2002; 99:3707-3716.
    • (2002) Blood , vol.99 , pp. 3707-3716
    • Miwa, T.1    Zhou, L.2    Hilliard, B.3
  • 67
    • 0033574577 scopus 로고    scopus 로고
    • Recombinant glycoproteins that inhibit complement activation and also bind the selectin adhesion molecules
    • Rittershaus CW, Thomas LJ, Miller DP, et al. Recombinant glycoproteins that inhibit complement activation and also bind the selectin adhesion molecules. J Biol Chem 1999; 274:11237-11244.
    • (1999) J Biol Chem , vol.274 , pp. 11237-11244
    • Rittershaus, C.W.1    Thomas, L.J.2    Miller, D.P.3
  • 68
    • 0346023953 scopus 로고    scopus 로고
    • ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement
    • Spitzer D, Unsinger J, Bessler M, Atkinson JP. ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement. Mol Immunol 2004; 40:911-919. Red blood cell-specific targeting of complement inhibitors was shown by this study's innovative approach of using antibody fragments with specificity to a highly expressed red cell protein.
    • (2004) Mol Immunol , vol.40 , pp. 911-919
    • Spitzer, D.1    Unsinger, J.2    Bessler, M.3    Atkinson, J.P.4
  • 69
    • 0033752720 scopus 로고    scopus 로고
    • Systemic lupus erythematosus, complement deficiency, and apoptosis
    • Pickering MC, Botto M, Taylor PR, et al. Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol 2000; 76:227-324.
    • (2000) Adv Immunol , vol.76 , pp. 227-324
    • Pickering, M.C.1    Botto, M.2    Taylor, P.R.3
  • 70
    • 0019452691 scopus 로고
    • Defective immune-adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus
    • Miyakawa Y, Yamada A, Kosaka K, et al. Defective immune-adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus. Lancet 1981; 2:493-497.
    • (1981) Lancet , vol.2 , pp. 493-497
    • Miyakawa, Y.1    Yamada, A.2    Kosaka, K.3
  • 71
    • 2542505506 scopus 로고    scopus 로고
    • The role of complement in the development of systemic lupus erythematosus
    • Manderson AP, Botto M, Walport MJ. The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 2004; 22:431-456.
    • (2004) Annu Rev Immunol , vol.22 , pp. 431-456
    • Manderson, A.P.1    Botto, M.2    Walport, M.J.3
  • 72
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper C, Chan AC, Green JM, et al. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003; 421:388-392. In this exciting study, the complement regulatory protein CD46 was shown to be a costimulatory molecule for development of T-regulatory cells, providing a potential signaling target for generating such cells for prevention and treatment of autoimmune disease.
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1    Chan, A.C.2    Green, J.M.3
  • 73
  • 74
    • 0035554950 scopus 로고    scopus 로고
    • Autoimmunity provoked by infection: How good is the case for T cell epitope mimicry?
    • Benoist C, Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2001; 2:797-801.
    • (2001) Nat Immunol , vol.2 , pp. 797-801
    • Benoist, C.1    Mathis, D.2
  • 75
    • 0026077255 scopus 로고
    • Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity
    • Adams EM, Brown MC, Nunge M, et al. Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J Immunol 1991; 147:3005-3011.
    • (1991) J Immunol , vol.147 , pp. 3005-3011
    • Adams, E.M.1    Brown, M.C.2    Nunge, M.3
  • 76
    • 0037114635 scopus 로고    scopus 로고
    • Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen
    • Hall AM, Ward FJ, Vickers MA, et al. Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen. Blood 2002; 100:4529-4536.
    • (2002) Blood , vol.100 , pp. 4529-4536
    • Hall, A.M.1    Ward, F.J.2    Vickers, M.A.3
  • 78
    • 0032147101 scopus 로고    scopus 로고
    • CD21/CD35in B cell activation
    • Carroll MC. CD21/CD35in B cell activation. Semin Immunol 1998; 10:279-286.
    • (1998) Semin Immunol , vol.10 , pp. 279-286
    • Carroll, M.C.1
  • 79
    • 5144222918 scopus 로고    scopus 로고
    • Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells
    • Bluestone JA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A 2004; 101(suppl 2): 14622-14626.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.2 SUPPL. , pp. 14622-14626
    • Bluestone, J.A.1    Tang, Q.2
  • 80
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22:531-562.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1


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