Transcutaneous delivery of levodopa: Enhancement by fatty acid synthesis inhibition

Molecular Pharmaceutics

Volumn 2, Issue 1, 2005, Pages 57-63

  Babita, Kumar ^a   Tiwary, Ashok K ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Cerulenin; Differential scanning calorimetry; Levodopa; Skin fatty acid; Transcutaneous delivery

Indexed keywords

ALCOHOL; CALCIUM CHLORIDE; CARBIDOPA; CERULENIN; FATTY ACID; LEVODOPA; PROPYLENE GLYCOL; TRIACYLGLYCEROL; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; ENTHALPY; ENZYME INHIBITION; EPIDERMIS; FATTY ACID SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSDERMAL PATCH;

ADMINISTRATION, CUTANEOUS; ANIMALS; CALCIUM; CALORIMETRY, DIFFERENTIAL SCANNING; CERULENIN; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; LEVODOPA; MALE; PERMEABILITY; RATS; RATS, WISTAR; SOLVENTS; TRIGLYCERIDES; VERAPAMIL;

EID: 14644386839     PISSN: 15438384     EISSN: None     Source Type: Journal    
DOI: 10.1021/mp049926u     Document Type: Article

References (27)

1. Kankkunen, T.; Huupponen, I.; Lahtinen, K.; Sundell, M.; Ekman, K.; Kyosti, K.; Hirvonen, J. Improved Stability and Release Control of Levodopa and Metaraminol Using Ion-Exchange Fibres and Transdermal Iontophoresis. Eur. J. Pharm. Sci. 2003, 16, 273-280.
2. Harder, S.; Bass, H.; Rietbrock, S. Concentration Effect Relationship of Levodopa in Patients with Parkinson's Disease. Clin. Pharmacokinet. 1995, 29, 243-256.
3. Yamaguchi, Y.; Usumi, T.; Natsuma, H.; Aoyagi, T.; Nagase, Y.; Sugibayashi, K.; Morimoto, Y. Evaluation of Skin Permeability of Drugs by Newly Prepared Polymer Membranes. Chem. Pharm. Bull. 1997, 45, 537-541.
4. Elias, P. M.; Menon, G. K. Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier. Adv. Lipid Res. 1991, 24, 1-26.
5. Hedberg, C. L.; Wertz, P. W.; Downing, D. T.; The Nonpolar Lipids of Pig Epidermis. J. Invest. Dermatol. 1988, 90, 225-229.
6. Ottey, K. A.; Wood, L. C.; Grunfeld, C.; Elias, P. M.; Feingold, K. R. Cutaneous Permeability Barrier Disruption Increases Fatty Acid Synthesis Enzyme Activity in the Epidermis of Hairless Mice. J. Invest. Dermatol. 1995, 104, 401-404.
7. Thupari, J. N.; Pinn, M. L.; Kuhajda, F. P. Fatty Acid Synthase Inhibition in Human Breast Cancer Cells Leads to Malonyl CoA-Induced Inhibition of Fatty Acid Oxidation and Cytotoxicity. Biochem. Biophys. Res. Commun. 2001, 285, 217-223.
8. Halvorson, D. L.; Mccune, S. A. Inhibition of Fatty Acid Synthesis in Isolated Adipocytes by 5-(Tetradecyloxy)-2-Furoic Acid. Lipids 1984, 19, 851-856.
9. Vance, D.; Goldberg, I.; Mitsuhashi, O.; Bloch, K. Inhibition of Fatty Acid Synthetases by the Antibiotic Cerulenin. Biochem. Biophys. Res. Commun. 1972, 48, 649-656.
10. Feingold, K. R. The Regulation and Role of Lipid Synthesis. Adv. Lipid Res. 1991, 24, 57-82.
11. Grubauer, G.; Feingold, K. R.; Elias, P. M. Relationship of Epidermal Lipogenesis to Cutaneous Barrier Function. J. Lipid Res. 1987, 28, 746-752.
12. Holleran, W. M.; Feingold, K. R.; Mao-Quing, M.; Gao, W. N.; Lee, J. M.; Elias, P. M. Regulation of Epidermal Sphingolipid Synthesis by Permeability Barrier Function. J. Lipid Res. 1991, 32, 1151-1158.
13. Tsai, J. C.; Guy, R. H.; Thornfeldt, C. R.; Gao, W. N.; Feingold, K. R.; Elias, P. M. Metabolic Approaches to Enhance Transdermal Drug Delivery.1. Effect of Lipid Synthesis Inhibitors. J. Pharm. Sci. 1996, 85, 643-648.
14. Babita; Gupta, S.; Tiwary, A. K. Role of Sphingosine Synthesis Inhibition in Transcutaneous Delivery of Levodopa. Int. J. Pharm. 2002, 238, 43-50.
15. Gupta, M.; Mahajan, A.; Babita; Gupta, S.; Tiwary, A. K. Inhibition of Skin Sphingosine Synthesis: Enhanced Percutaneous Permeation of 5-Fluorouracil. Pharmazie 2003, 59, 212-216.
16. Lee, S. H.; Elias, P. M.; Proksch, E.; Menon, G. K.; Mao-Qiang, M.; Feingold, K. R. Calcium and Potassium are Important Regulators of Barrier Homeostasis in Murine Epidermis. J. Clin. Invest. 1992, 89, 530-538.
17. Cornwell, P. A.; Barry, B. W.; Bouwstra, J. A.; Goods, G. S. Mode of Action of Terpene Penetration Enhancers in Human Skin: Differential Scanning Calorimetry, Small X-Ray Diffraction and Enhancer Uptake Studies. Int. J. Pharm. 1996, 127, 9-26.
18. Gamez, R.; Hagel, R. B.; MacMullan, E. A. Analytical Profile of Levodopa. Anal. Profiles Drug Subst. 1976, 5, 189-223.
19. Cotler, S.; Holazo, A.; Boxenbaum, H. B.; Kaplan, S. A. Influence of Route of Administration on Physiological Availability of Levodopa in Dogs. J. Pharm. Sci. 1976, 65, 822-827.
20. Vaddi, H. K.; Ho, P. C.; Chan, S. Y. Terpenes in Propylene Glycol as Skin-Penetration Enhancers: Permeation and Partition of Haloperidol, Fourier Transform Infrared Spectroscopy, and Differential Scanning Calorimetry. J. Pharm. Sci. 2002, 91, 1639-1651.
21. Ghanem, A. H.; Mahmoud, H.; Higuchi, W. I.; Liu, P.; Good, W. R. The Effects of Ethanol transport of Lipophilic and Polar Permeants Across Hairless Mouse Skin: Methods/Validation of a Novel Approach. Int. J. Pharm. 1992, 78, 137-156.
22. Krill, S. L.; Knutson, K.; Higuchi, W. I. Ethanol Effects on the Stratum Corneum Lipid Phase Behaviour. Biochim. Biophys. Acta 1992, 112, 273-280.
23. Nair, V. B.; Panchagnula, R. Effect of Iontophoresis and Fatty Acids on Permeation of Arginine Vasopressin Through Rat Skin. Pharm. Res. 2003, 47, 563-569.
24. Levang, A. K.; Zhao, K.; Singh, J. Effect of Ethanol/Propylene Glycol on the In Vitro Percutaneous Absorption of Aspirin, Biophysical Changes and Macroscopic Barrier Properties of the Skin. Int. J. Pharm. 1999, 181, 255-263.
25. Mao-Qiang, M.; Elias, P. M.; Feingold, K. R. Fatty Acids are Required for Epidermal Permeability Barrier Function. J. Clin. Invest. 1993, 92, 791-798.
26. Bentley, M. V.; Vianna, R. F.; Wilson, S.; Collett, J. H. Characterization of the Influence of Some Cyclodextrins on the Stratum Corneum from the Hairless Mouse. J. Pharm. Pharmacol. 1997, 49, 397-402.
27. Sudo, J.-i.; Iwase, H.; Terui, J.; Kakuno, K.; Soyama, M.; Takayama, K.; Nagai, T. Transdermal Absorption of L-Dopa from Hydrogels in Rats. Eur. J. Pharm. Sci. 1998, 7, 67-71.