Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes

Gene

Volumn 331, Issue 1-2, 2004, Pages 33-40

  Musio, Antonio ^a   Mariani, Tullio ^b   Montagna, Cristina ^c   Zambroni, Desirèe ^a   Ascoli, Cesare ^b   Ried, Thomas ^c   Vezzoni, Paolo ^a  

^a CNR   (Italy)

^b AREA DELLA RICERCA   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cell cycle; Centromere separation; DMEM; Dulbeco's minimal essential medium; FCS; FITC; Flourescein isothiocynate; Foetal calf serum; INCENP; PD; Population doubling; Roberts syndrome; SKY; TdT medicated dUTP nick end labelling; TUNEL; ZW10; ZWINT 1

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHROMOSOME PROTEIN; INNER CENTROMERE PROTEIN; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; ATOMIC FORCE MICROSCOPY; CENTROMERE; CHROMATID; CHROMOSOME REARRANGEMENT; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CYTOGENETICS; CYTOLOGY; DISEASE MARKER; GENE; GENE INACTIVATION; HUMAN; HUMAN CELL; MICRONUCLEUS; MITOSIS; MITOSIS SPINDLE; PHENOTYPE; PRIORITY JOURNAL; ROBERTS SYNDROME; SPECTRAL KARYOTYPING; ZW 10 GENE; ZWINT 1 GENE;

ABNORMALITIES, MULTIPLE; ANEUPLOIDY; CAFFEINE; CELL CYCLE; CELL DIVISION; CELL LINE; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME ABERRATIONS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GROWTH DISORDERS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KARYOTYPING; KINETOCHORES; LIMB DEFORMITIES, CONGENITAL; MICROSCOPY, ATOMIC FORCE; MICROTUBULE-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES, ANTISENSE; PHENOTYPE; SYNDROME;

EID: 14544308098     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2004.01.028     Document Type: Article

References (20)

1. Adams R.R., Carmena M., Earnshaw W.C. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 11:2001;49-54.
2. Bannister A.J., Zegerman P., Partridge J.F., Miska E.A., Thomas J.O., Allshire R.C., Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. 410:2001;120-124.
3. Chan G.K., Jablonski S.A., Starr D.A., Goldberg M.L., Yen T.J. Human Zw10 and Rod are mitotic checkpoint proteins that bind to kinetochores. Nat. Cell Biol. 2:2000;944-947.
4. Dev V.G., Wertelecki W. Elimination of abnormal centromere-chromatid apposition (ACCA) in slected human-mouse cell hybrids. Am. J. Hum. Genet. 36:1984;90S.
5. Earnshaw W.C., Cooke C.A. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. J. Cell. Sci. 98:1991;443-461.
6. Jabs E.W., Tuck-Muller C.M., Cusano R., Rattner J.B. Studies of mitotic and centromeric abnormalities in Roberts syndrome: implications for a defect in the mitotic mechanism. Chromosoma. 100:1991;251-261.
7. Krassikoff N.E., Cowan J., Parry D.M., Francke U. Chromatid repulsion associated with Roberts/SC phocomelia syndrome is reduced in malignant cells and not expressed in interspecies somatic-cell hybrids. Am. J. Hum. Genet. 39:1986;618-630.
8. Lachner M., O'Carroll D., Rea S., Mechtler K., Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 410:2001;116-120.
9. Mackay A.M., Ainsztein A.M., Eckley D.M., Earnshaw W.C. A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis. J. Cell Biol. 140:1998;991-1002.
10. Mariani T., Musio A., Frediani C., Sbrana I., Ascoli C. An atomic force microscope for cytological and histological investigation. J. Microsc. 176:1994;121-131.
11. McDaniel L.D., Prueitt R., Probst L.C., Wilson K.S., Tomkins D., Wilson G.N., Schultz R.A. Novel assay for Roberts syndrome assigns variable phenotypes to one complementation group. Am. J. Med. Genet. 93:2000;223-229.
12. Musio A., Mariani T., Frediani C., Sbrana I., Ascoli C. Longitudinal patterns similar to G-banding in untreated human chromosomes: evidence from atomic force microscopy. Chromosoma. 103:1994;225-229.
13. Musio A., Rainaldi G., Sbrana I. Spontaneous and aphidicolin-sensitive fragile site 3cen co-localize with (TTAGGG)n telomeric sequences in Chinese hamster cell. Cytogenet. Cell Genet. 7:1996;159-163.
14. Musio A., Montagna C., Zambroni D., Indino E., Barbieri O., Citti L., Villa A., Ried T., Vezzoni P. Inhibition of BUB1 results in genomic instabilty and anchorage-independent growth of normal human fibroblasts. Cancer Res. 63:2003;2855-2863.
15. Parry D.M., Mulvihill J.J., Tsai S., Kaiser-Kupfer M.I., Cowan J.M. SC Phocomelia syndrome, premature centromere separation, and congenital cranial nerve paralysis in two sisters, one with malignant melanoma. Am. J. Med. Genet. 24:1986;653-672.
16. Schrock E., du Manoir S., Veldman T., Schoell B., Wienberg J., Ferguson-Smith M.A., Ning Y., Ledbetter D.H., Bar-Am I., Soenksen D., Garini Y., Ried T. Multicolor spectral karyotyping of human chromosomes. Science. 273:1996;494-497.
17. Starr D.A., Saffery R., Li Z., Simpson A.E., Choo K.H., Yen T.J., Goldberg M.L. Hzwint-1, a novel human kinetochore component that interacts with HZW10. J. Cell Sci. 113:2000;1939-1950.
18. Tomkins D.J., Sisken J.E. Abnormalities in the cell-division cycle in Roberts syndrome fibroblasts: a cellular basis for the phenotypic characteristics? Am. J. Hum. Genet. 36:1984;1332-1340.
19. Tomkins D.J., Hunter A., Roberts M. Cytogenetic findings in Roberts'-SC phocomelia syndrome(s). Am. J. Med. Genet. 4:1979;17-26.
20. Van den Berg D.J., Francke U. Roberts syndrome: a review of 100 cases and a new rating system for severity. Am. J. Med. Genet. 47:1993;1104-1123.