The thymus plays a role in oral tolerance induction in experimental autoimmune encephalomyelitis

Annals of the New York Academy of Sciences

Volumn 1029, Issue , 2004, Pages 402-404

  Song, Fei ^a,b   Gienapp, Ingrid E ^a   Shawler, Todd ^a   Guan, Zhen ^a   Whitacre, Caroline C ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Autoimmunity; EAE MS; Oral tolerance; T cell receptor; Thymus

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; AUTOIMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEEDING; IMMUNOLOGICAL TOLERANCE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; ORAL TOLERANCE; T LYMPHOCYTE; THYMECTOMY; THYMOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 14544299142     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1309.047     Document Type: Conference Paper

References (5)

1. BRUNO, R. et al. 2002. Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus. Eur. J. Immunol. 32: 2737-2747.
2. BENSON, J.M. et al. 2000. T-cell activation and receptor downmodulation precede deletion induced by mucosally administered antigen. J. Clin. Invest. 106: 1031-1038.
3. ZHANG, X. et al. 2001. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J. Immunol. 167: 4245-4253.
4. PAPIERNIK, M. et al. 1998. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10: 371-378.
5. THORSTENSON, K.M. & A. KHORUTS. 2001. Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167: 188-195.