Do high levels of viral replication contribute to fulminant hepatitis A?

Liver International

Volumn 25, Issue 1, 2005, Pages 194-195

  Fujiwara, Keiichi ^a,d   Yokosuka, Osamu ^a   Imazeki, Fumio ^a   Saisho, Hiramitsu ^a   Miki, Makoto ^b   Omata, Maseo ^c  

^a CHIBA UNIVERSITY   (Japan)

^b Department of Internal Medicine   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d Kawatetsu Chiba Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; IMMUNOGLOBULIN M ANTIBODY; VIRUS RNA;

5' UNTRANSLATED REGION; ADULT; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; GENE AMPLIFICATION; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; JAPAN; LETTER; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; VIRUS REPLICATION;

5' UNTRANSLATED REGIONS; ADULT; HEPATITIS A; HEPATITIS A ANTIBODIES; HEPATITIS A VIRUS; HUMANS; IMMUNOGLOBULIN M; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRULENCE; VIRUS REPLICATION;

EID: 14544282371     PISSN: 14783223     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2004.0981.x     Document Type: Letter

References (5)

1. O'Grady J G. Fulminant hepatitis in patients with chronic liver disease. J Viral Hepatitis 2000; 7: 9-10.
2. Willner I R, Uhl M D, Howard S C, Williams E Q, Riely C A, Waters B. Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. Ann Intern Med 1998; 128: 111-4.
3. Fujiwara K, Yokosuka O, Ehata T, et al. Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A. Hepatology 1997; 26: 1634-9.
4. Fujiwara K, Yokosuka O, Fukai K, et al. Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis. J Hepatol 2001; 35: 112-9.
5. Fujiwara K, Yokosuka O, Ehata T, et al. Association between severity of type A hepatitis and nucleotide variations in the 5′ nontranslated region of hepatitis A virus RNA: strains from fulminant hepatitis have fewer nucleotide substitutions. Gut 2002; 51: 82-8.