Preproinsulin-specific CD8+ T cells secrete IFNγ in human type 1 diabetes

Annals of the New York Academy of Sciences

Volumn 1037, Issue , 2004, Pages 22-25

  Rathmann, Silvia ^a   Rajasalu, Tarvo ^a   Rosinger, Silke ^a   Schlosser, Michael ^b   Eiermann, Thomas ^c   Boehm, Bernhard O ^a   Durinovic Belló, Ivana ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

CD8+ T cells; IFN and IL 4; Preproinsulin peptides; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; PREPROINSULIN; SYNTHETIC PEPTIDE;

CONFERENCE PAPER; CYTOTOXICITY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; T LYMPHOCYTE;

EID: 14544276481     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1337.004     Document Type: Conference Paper

References (6)

1. SERREZE, D.V., T.M. HOLL, M.P. MARRON, et al. 2004. MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice. J. Immunol. 172: 871-879.
2. DURINOVIC-BELLO, I.I., M. SCHLOSSER, M. RIEDL, et al. 2004. Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 type 1 diabetes. Diabetologia 47: 439-450.
3. OTT, P.A., M.T. DITTRICH, B.A. HERZOG, et al. 2004. T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J. Clin. Immunol. 24: 327-339.
4. WONG, F.S., J. KARTTUNEN, C. DUMONT, et al. 1999. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat. Med. 5: 1026-1031.
5. MCINERNEY, M.F., J. BURKEY, L. GUAN, et al. 2000. An islet-specific CD8+ T cell hybridoma generated from non-obese diabetic mice recognizes insulin as an autoantigen. Diabetes Res. Clin. Pract. 47: 151-168.
6. MUNTASELL, A., M. CARRASCAL, I. ALVAREZ, et al. 2004. Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: strong influence of invariant chain and HLA-DM expression on the nature of ligands. J. Immunol. 173: 1085-1093.