Hydrogen bond and other descriptors for thalidomide and its N-alkyl analogs; Prediction of physicochemical and biological properties

European Journal of Pharmaceutical Sciences

Volumn 21, Issue 4, 2004, Pages 465-469

  Abraham, Michael H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Blood brain distribution; Human intestinal absorption; Hydrogen bonding; N Alkylthalidomides; Skin permeation; Solvation equation; Thalidomide

Indexed keywords

THALIDOMIDE;

ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG SOLUBILITY; HUMAN; HYDROGEN BOND; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; SKIN PERMEABILITY;

CHEMISTRY, PHYSICAL; HUMANS; HYDROGEN BONDING; INTESTINAL ABSORPTION; PREDICTIVE VALUE OF TESTS; THALIDOMIDE;

EID: 1442357906     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2003.11.012     Document Type: Article

References (22)

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3. Abraham M.H., Chadha H.S., Whiting G.S., Mitchell R.C. Hydrogen bonding. 32. An analysis of water-octanol and water-alkane partitioning, and the Δ log P parameter of Seiler J. Pharm. Sci. 83:1994b;1085-1100.
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8. Abraham M.H., Benjelloun-Dakhama N., Gola J.M.R., Acree W.E. Jr., Cain W.S., Cometto-Muniz J.E. Solvation descriptors for ferrocene, and the estimation of some physicochemical and biochemical properties. New J. Chem. 24:2000a;825-829.
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10. Abraham M.H., Al-Hussaini A.J.M. Solvation descriptors for N-nitroso-dialkylamines calculation of some of their properties of environmental significance. J. Environ. Monit. 4:2002;743-746.
11. ChemSketch, 2000. Advanced Chemistry Development Inc., 90 Adelaide Street, West Suite 702, Toronto, Ont., Canada M5H 3V9.
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15. Green C.E., Abraham M.H., Acree W.E. Jr., De Fina K.M., Sharp T.L. Solvation descriptors for pesticides from the solubility of solids: diuron as an example. Pest. Manage. Sci. 56:2000;1043-1053.
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17. Leo, A.J., 2002. The Medicinal Chemistry Project, Pomona College, Claremont, CA 91711.
18. Leo, A.J., 2001. C log P for Windows, Version 4.0. Biobyte Corp., 201 West 4th St., Suite 204, Claremont, CA 91711.
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21. Platts J.A., Abraham M.H., Zhao Y.H., Hersey A., Ijaz L., Butina D. Correlation and prediction of a large blood-brain distribution data set - an LFER study. Eur. J. Med. Chem. 36:2001;719-720.
22. Zhao Y.H., Le J., Abraham M.H., Hersey A., Eddershaw P.E., Luscombe C.N., Butina D., Beck G., Sherborne B., Cooper I., Platts J.A. Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors. J. Pharm. Sci. 90:2001;749-784.