Bone morphogenic protein-4 expression in vascular lesions of calciphylaxis

Journal of Nephrology

Volumn 16, Issue 5, 2003, Pages 728-732

  Griethe, Wanja ^a   Schmitt, Roland ^a   Jurgensen, Jan Steffen ^a   Bachmann, Sebastian ^a   Eckardt, Kai Uwe ^a   Schindler, Ralf ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; Bone morphogenic protein; Calcific uremic arteriolopathy; Calciphylaxis; Hypercalcemia; Hyperparathyroidism; Hyperphosphatemia; Media sclerosis; Vascular calcification

Indexed keywords

ANTIBIOTIC AGENT; ANTIVITAMIN K; BONE MORPHOGENETIC PROTEIN 4; CREATININE; CYCLOSPORIN A; CYTOKINE; METHYLPREDNISOLONE; OXYGEN; PHENPROCOUMON; STEROID; BONE MORPHOGENETIC PROTEIN;

ADULT; ARTERIOLE; ARTICLE; BLOOD VESSEL CALCIFICATION; CALCINOSIS; CASE REPORT; CHRONIC GLOMERULONEPHRITIS; CREATININE BLOOD LEVEL; CYTOPLASM; DEBRIDEMENT; DISEASE COURSE; GRAFT REJECTION; HAIR FOLLICLE; HOSPITAL ADMISSION; HUMAN; HUMAN TISSUE; HYPERBARIC OXYGEN; HYPERCALCEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FAILURE; KIDNEY GRAFT; MALE; PARATHYROIDECTOMY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SKIN BIOPSY; SKIN CELL; SKIN ULCER; UREMIA; VASCULAR LESION; BLOOD; METABOLISM; MIDDLE AGED; NECROSIS; PATHOLOGY; SKIN; SKIN BLOOD VESSEL DISORDER; VASCULAR DISEASE; VASCULARIZATION;

BONE MORPHOGENETIC PROTEINS; CALCIPHYLAXIS; CREATININE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NECROSIS; SKIN; SKIN DISEASES, VASCULAR; UREMIA; VASCULAR DISEASES;

EID: 1442356445     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Moe SM, O'Neill KD, Duan D. Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int 2002; 61: 638-47.
2. Ahmed S, O'Neill KD, Hood AF, Evan AP, Moe SM. Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis 2001; 37: 1267-76.
3. Leong LM, Brickell PM. Bone morphogenic protein-4. Int J Biochem Cell Biol 1996; 28: 1293-6.
4. Mohler ER, 3rd, Gannon F, Reynolds C. Bone formation and inflammation in cardiac valves. Circulation 2001; 103: 1522-8.
5. Dhore CR, Cleutjens JP, Lutgens E. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 2001; 21: 1998-2003.
6. Levin A, Mehta RL, Goldstein MB. Mathematical formulation to help identify the patient at risk of ischemic tissue necrosis -a potentially lethal complication of chronic renal failure. Am J Nephrol 1993; 13: 448-53.
7. Budisavljevic MN, Cheek D, Ploth DW. Calciphylaxis in chronic renal failure. J Am Soc Nephrol 1996; 7: 978-82.
8. Mazhar AR, Johnson RJ, Gillen D. Risk factors and mortality associated with calciphylaxis in end-stage renal disease. Kidney Int 2001; 60: 324-32.
9. Podymow T, Wherrett C, Burns KD. Hyperbaric oxygen in the treatment of calciphylaxis: a case series. Nephrol Dial Transplant 2001; 16: 2176-80.
10. Fine A, Zacharias J. Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int 2002; 61: 2210-7.
11. Cozzolino M, Dusso AS, Slatopolsky E. Role of calcium-phosphate product and bone-associated proteins on vascular calcification in renal failure. J Am Soc Nephrol 2001; 12: 2511-6.
12. Canfield AE, Farrington C, Dziobon MD. The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study. J Pathol 2002; 196: 228-34.
13. Shanahan CM, Cary NR, Salisbury JR. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 1999; 100: 2168-76.
14. Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 1998; 8: 357-75.
15. Van den Wijngaard A, Mulder WR, Dijkema R. Antiestrogens specifically up-regulate bone morphogenetic protein-4 promoter activity in human osteoblastic cells. Mol Endocrinol 2000; 14: 623-33.
16. Gannon FH, Glaser D, Caron R. Mast cell involvement in fibrodysplasia ossificans progressiva. Hum Pathol 2001; 32: 842-8.
17. Demer LL, Tintut Y, Parhami F. Novel mechanisms in accelerated vascular calcification in renal disease patients. Curr Opin Nephrol Hypertens 2002; 11: 437-43.
18. Chaulet H, Desgranges C, Renault MA. Extracellular nucleotides induce arterial smooth muscle cell migration via osteopontin. Circ Res 2001; 89: 772-8.
19. Botchkarev VA, Botchkareva NV, Nakamura M. Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J 2001; 15: 2205-14.